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Table 4 Factors associated with PIMs and DDIs in elderly (> 70 years) multidose users in Norway in 2018

From: Potentially inappropriate prescribing to older patients receiving multidose drug dispensing

Study population Potentially inappropriate medications (PIM) Drug-drug interactions
(DDI)
  Type Ba Type Ca
  n n (%) OR (95% CI) n (%) OR (95% CI) n (%) n (%)
Age 70–79 11,435 4072 (35.6) 1 (ref) 7227 (63.2) 1 (ref) 7171 (62.7) 493 (4.3)
Age 80–89 21,633 5449 (25.2) 0.61 (0.57–0.64) 13,000 (60.1) 0.90 (0.85–0.95) 12,935 (59.8) 543 (2.5)
Age 90+ 12,525 2793 (22.3) 0.55 (0.52–0.59) 6785 (54.2) 0.76 (0.72–0.81) 6754 (53.9) 226 (1.8)
No. of drugs 45,593 NA 1.15b (1.15–1-16) NA 1.30b (1.28–1.30) NA NA
Male 15,503 8814 (22.6) 1 (ref) 8354 (53.9) 1 (ref) 8294 (53.5) 420 (2.7)
Female 30,090 3505 (29.3) 1.50 (1.43–1.58) 18,658 (62.0) 1.43 (1.37–1.50) 18,566 (61.7) 842 (2.8)
  1. a: Type B = “Precautions should be taken”, Type C = “should be avoided”
  2. b: Increase in odds for PIMs and DDIs for every one unit increase in the number of drugs