Table 3 Treatment Effects Compared to Placebo/Control in a Network Meta-Analysis Model Incorporating Randomized and Non-Randomized Studies: Fracture, Mortality, Cerebrovascular Event, and Fall
Intervention (vs. Placebo/Control) | Combined RCT + NRS RR (95% CrI) | RCT RR (95% CrI) | NRS RR (95% CrI) |
|---|---|---|---|
Fracture | |||
 Anticonvulsants | 0.63 (0.05 to 6.54) | 0.63 (0.08 to 4.33) | – |
 Antidepressants | 0.82 (0.16 to 3.24) | 0.74 (0.12 to 3.11) | 0.94 (0.25 to 2.39) |
 Antipsychotics | 0.89 (0.29 to 2.68) | 0.77 (0.36 to 1.58) | 1.05 (0.41 to 2.25) |
 Cholinesterase Inhibitor + Memantine | 6.18 (0.5 to 325.1) | 6.1 (0.7 to 294.8) | – |
 Cholinesterase Inhibitors | 1.02 (0.36 to 2.76) | 1.23 (0.81 to 1.91) | 0.84 (0.48 to 1.52) |
 Memantine | 0.59 (0.1 to 3.38) | 0.59 (0.17 to 1.93) | – |
Mortality | |||
 Anticonvulsants | 1.28 (0.82 to 1.99) | 1.27 (0.81 to 2.0) | 1.29 (0.85 to 1.9) |
 Antidepressants | 0.86 (0.5 to 1.48) | 0.86 (0.49 to 1.5) | 0.87 (0.52 to 1.43) |
 Antipsychotics | 1.33 (1.01 to 1.73) | 1.28 (1 to 1.59) | 1.38 (1.13 to 1.69) |
 Anxiolytic/hypnotics | 0.84 (0.41 to 1.72) | – | 0.84 (0.44 to 1.61) |
 Cholinesterase Inhibitor + Memantine | 1.04 (0.68 to 1.58) | 1.02 (0.66 to 1.52) | 1.06 (0.72 to 1.57) |
 Cholinesterase Inhibitors | 0.84 (0.65 to 1.1) | 0.84 (0.71 to 0.99) | 0.84 (0.68 to 1.04) |
 Memantine | 1.15 (0.84 to 1.59) | 1.12 (0.87 to 1.43) | 1.17 (0.87 to 1.64) |
Cerebrovascular Event | |||
 Anticonvulsants | 1.03 (0.1 to 11.56) | 1.02 (0.15 to 8.05) | – |
 Antidepressants | 0.27 (< 0.01 to 8.34) | 0.28 (< 0.01 to 6.8) | – |
 Antipsychotics | 1.76 (0.57 to 4.79) | 2.02 (1.25 to 3.39) | 1.51 (0.63 to 3.28) |
 Cholinesterase Inhibitor + Memantine | 1.04 (0.16 to 5.73) | 1.05 (0.27 to 3.29) | – |
 Cholinesterase Inhibitors | 0.93 (0.3 to 2.5) | 0.99 (0.72 to 1.42) | 0.86 (0.33 to 1.89) |
 Dextromethorphan-Quinidine | 1.11 (0.03 to 40.95) | 1.11 (0.04 to 30.25) | – |
 Memantine | 0.76 (0.18 to 3.11) | 0.76 (0.45 to 1.28) | – |
Fall | |||
 Anticonvulsants | 1.09 (0.26 to 4.6) | 1.09 (0.64 to 1.89) | – |
 Antidepressants | 1.32 (0.49 to 3.98) | 1.16 (0.67 to 1.97) | 1.59 (0.79 to 2.84) |
 Antipsychotics | 1.21 (0.5 to 3.74) | 1.05 (0.91 to 1.23) | 1.54 (0.82 to 2.88) |
 Cholinesterase Inhibitor + Memantine | 0.97 (0.24 to 3.94) | 0.96 (0.66 to 1.43) | – |
 Cholinesterase Inhibitors | 0.94 (0.24 to 3.73) | 0.94 (0.79 to 1.14) | – |
 Dextromethorphan-Quinidine | 3.66 (0.72 to 18.91) | 3.65 (1.4 to 10.42) | – |
 Memantine | 0.95 (0.24 to 3.82) | 0.95 (0.79 to 1.15) | – |