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Table 2 Differences between means for ocular biomarkers in both the healthy and the CI nonagenarian groups

From: Ocular biomarkers for cognitive impairment in nonagenarians; a prospective cross-sectional study

 

Healthy nonagenarians

CI nonagenarians

SE

p-value

Macular retinal layer thickness:

 Total RT inner ring (μm)

323.5

317.3

5.0

0.218

 Total RT outer ring (μm)

282.2

276.1

4.0

0.133

 RNFL inner ring (μm)

23.0

22.2

0.8

0.353

 RNFL outer ring (μm)

36.4

35.5

1.4

0.518

 GCL inner ring (μm)

43.9

42.9

1.6

0.550

 GCL outer ring (μm)

30.0

29.9

1.1

0.940

 IPL inner ring (μm)

36.6

35.5

1.0

0.275

 IPL outer ring (μm)

25.5

24.9

0.8

0.449

Peripapillary RNFL:

 Average (μm)

88.3

89.1

2.7

0.762

 Nasal superior (μm)

90.6

96.6

4.9

0.229

 Nasal (μm)

67.1

69.9

3.5

0.428

 Nasal inferior (μm)

101.9

102.3

5.3

0.940

 Temporal inferior (μm)

123.0

122.1

5.2

0.868

 Temporal (μm)

69.1

66.9

3.2

0.471

 Temporal superior (μm)

118.9

118.0

4.5

0.854

Retinal vascular parameters:

 CRAE

123.6

120.3

2.3

0.156

 CRVE

184.3

179.7

4.6

0.325

 AVR

0.676

0.673

0.014

0.818

 FDa

1.152

1.152

0.011

0.977

 FDv

1.137

1.137

0.011

0.987

 cTORTaa

−9.75

−9.80

0.062

0.407

 cTORTva

−9.73

−9.69

0.054

0.472

  1. Linear regression, corrected for age, sex and diabetes
  2. CI Cognitively Impaired, SE Standard Error of difference, RT Retinal Thickness, RNFL Retinal Nerve Fiber Layer, GCL Ganglion Cell Layer, IPL Inner Plexiform Layer, CRAE Central Retinal Artery Equivalent, CRVE Central Retinal Vein Equivalent, AVR Arteriole-Venular Ratio, FDa Fractal Dimension of arteries, FDv Fractal Dimension of veins, cTORTa curvature Tortuosity of arteries, cTORTv curvature Tortuosity of veins
  3. aLog transformation applied