Table 2 Associations between liver enzyme elevation and various demographic and clinical variables
From: A prospective study of hepatic safety of statins used in very elderly patients
Characteristics | Presence of liver enzyme elevation | P value | Odds ratio (95% CI) | |
|---|---|---|---|---|
Yes | No | |||
(n = 24, 4.7%) | (n = 491, 95.3%) | |||
Age (years) | 82.6 ± 3.8a | 83.9 ± 3.4a | ||
80 ≃ 85 | 19(3.7%)b | 308(59.8%) | 1.000 | |
85 ≃ 90 | 3(0.6%) | 149(28.9%) | 0.075 | 0.326(0.095, 1.120) |
≥ 90 | 2(0.4%) | 34(6.6%) | 0.950 | 0.954(0.213, 4.271) |
Sex | ||||
Male | 20(3.9%) | 390(75.7%) | 1.000 | |
Female | 4(0.8%) | 101(19.6%) | 0.644 | 0.772(0.258, 2.310) |
Hepatitis B | ||||
No | 16(3.1%) | 477(92.6%) | 1.000 | |
Yes | 8(1.6%) | 14(2.7%) | < 0.001 | 17.036(6.259, 46.371) |
Fatty liver | ||||
No | 16(3.1%) | 450(87.4%) | 1.000 | |
Yes | 8(1.6%) | 41(8.0%) | 0.009 | 3.659(1.376, 9.726) |
Biliary calculus | ||||
No | 16(3.1%) | 411(79.8%) | 1.000 | |
Yes | 8(1.6%) | 80(15.5%) | 0.036 | 2.570(1.064, 6.206) |
Other diseases | ||||
≤ 2 | 1(0.2%) | 30(5.8%) | 1.000 | |
3 ≃ 5 | 9(1.7%) | 203(39.4%) | 0.790 | 1.330(0.163, 10.875) |
≥ 5 | 14(2.7%) | 258(50.1%) | 0.644 | 1.628(0.207, 12.820) |
Other drugs | ||||
< 5 | 5(1.0%) | 94(18.3%) | 1.000 | |
5 ≃ 10 | 16(3.1%) | 352(68.3%) | 0.765 | 0.855(0.305, 2.393) |
≥ 10 | 3(0.6%) | 45(8.7%) | 0.764 | 1.253(0.287, 5.477) |
Drinking habits | ||||
No drinking | 8(1.6%) | 483(93.8%) | 1.000 | |
Mild to moderate | 11(2.1%) | 3(0.6%) | 0.425 | 1.585(0.511, 4.914) |
Heavy | 5(1.0%) | 5(1.0%) | < 0.001 | 27.733(7.245,106.164) |
Statin variety | ||||
Simvastatin | 6(1.2%) | 92(17.5%) | 1.000 | |
Fluvastatin | 8(1.6%) | 108(21.0%) | 0.820 | 1.136(0.380, 3.393) |
Pravastatin | 4(0.8%) | 76(14.8%) | 0.747 | 0.807(0.220, 2.964) |
Rosuvastatin | 1(0.2%) | 84(16.3%) | 0.119 | 0.183(0.022, 1.548) |
Atorvastatin | 5(1.0%) | 131(25.4%) | 0.388 | 0.585(0.173, 1.975) |
Statin dose | ||||
Low | 4(0.8%) | 66(12.8%) | 1.000 | |
Standard | 20(3.9%) | 425(82.5%) | 0.653 | 0.776(0.257, 2.342) |