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Table 3 Univariate and multivariate analyses of outcomes in the < 75-year-old group

From: Predictors of clinical outcomes after cardiac resynchronization therapy in patients ≥75 years of age: a retrospective cohort study

 Univariate analysisMultivariate analysis
Primary endpointOR (95% CI)p valueOR (95% CI)p value
Atrial fibrillation0.36 (0.18–0.71)0.0030.28 (0.13–0.62)0.001
CRT-D2.39 (0.85–6.70)0.09  
Male sex2.39 (0.85–6.70)0.09  
CKD0.53 (0.26–1.07)0.08  
Ivabradine2.25 (0.85–5.97)0.10  
NYHA ≥III1.74 (0.89–3.41)0.112.09 (0.95–4.59)0.07
QRS < 130 ms0.51 (0.21–1.24)0.13  
QRS > 150 ms1.63 (0.83–3.17)0.15  
 Univariate analysisMultivariate analysis
(model 1 with atrial fibrillation)
Multivariate analysis
(model 2 with anticoagulation)
One-year mortalityOR (95% CI)p valueOR (95% CI)p valueOR (95% CI)p value
Atrial fibrillation23.68 (3.04–184.30)< 0.00114.35 (1.6–125.90)0.02  
Rescue CRT17.48 (4.97–61.44)< 0.00114.32 (2.61–79.20)0.00215.81 (3.35–75.10)< 0.001
CRT-D0.11 (0.04–0.34)< 0.001    
Beta-blockers0.16 (0.05–0.51)0.001    
CKD5.93 (1.61–21.83)0.0035.96 (1.13–31.30)0.047.65 (1.47–39.61)0.02
Anticoagulation7.71 (1.68–33.26)0.003  5.32 (0.96–29.40)0.06
ACEI-ARB0.26 (0.09–0.78)0.01    
Diabetes mellitus2.86 (1.02–8.01)0.04    
Loop diuretics5.67 (0.72–44.56)0.07    
NYHA ≥III4.24 (1.16–15-48)0.02    
QRS > 150 ms0.46 (0.15–1.38)0.16    
Complications2.06 (0.69–6.08)0.194.20 (0.91–18.91)0.07  
  1. Anticoagulation and atrial fibrillation were significantly correlated in the < 75-year-old group (Pearson coefficient 0.69, p < 0.001). We performed two different regression models if the p values were both < 0.2 in the univariate analysis. We reported here variables with p values ≤0.2 in the univariate analysis and ≤ 0.10 in the multivariate analysis. ACEI: angiotensin-converting enzyme inhibitor; ARB: angiotensin II receptor blocker; CKD: chronic kidney disease (defined by estimated glomerular filtration < 60 ml/mn/1.73 m2); CRT: cardiac resynchronization therapy; CRT-D: CRT with defibrillator; NYHA: New York Heart Association
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