From: Anticholinergic and benzodiazepine medication use and risk of incident dementia: a UK cohort study
Exposure and pattern of use | Dementia incidence | Unadjusted IRR (95% CI) | Adjustedb IRR (95% CI) | ||
---|---|---|---|---|---|
Cases | Total | %a | |||
BZD use | |||||
 None | 195 | 2819 | 9.0 | 1 (Ref.) | 1 (Ref.) |
 Any | 25 | 227 | 14.5 | 1.61 (1.06,2.46) | 1.06 (0.72,1.60) |
  New | 5 | 48 | 11.1 | 1.23 (0.51,2.96) | 0.65 (0.27,1.60) |
  Discontinuing | 6 | 57 | 14.1 | 1.57 (0.74,3.35) | 1.06 (0.53,2.14) |
  Recurrent | 14 | 122 | 16.0 | 1.78 (1.02,3.12) | 1.30 (0.79,2.14) |
ACB3 use | |||||
 None | 198 | 2876 | 9.1 | 1 (Ref.) | 1 (Ref.) |
 Any | 22 | 170 | 15.4 | 1.70 (1.09,2.65) | 1.28 (0.82,2.00) |
  New | 5 | 60 | 7.9 | 0.88 (0.37,2.09) | 0.87 (0.34,2.22) |
  Discontinuing | 5 | 40 | 20.1 | 2.22 (0.96,5.14) | 1.19 (0.53,2.68) |
  Recurrent | 12 | 70 | 18.6 | 2.05 (1.18,3.56) | 1.68 (1.00,2.82) |
ACB3 subclass | |||||
 Not antidepressants | 6 | 53 | 13.6 | 1.50 (0.68,3.32) | 1.74 (0.84,3.62) |
 Antidepressants | 16 | 117 | 16.1 | 1.78 (1.06,2.98) | 1.16 (0.69,1.94) |
ACB1 or ACB2 use | |||||
 None | 85 | 1438 | 8.3 | 1 (Ref.) | 1 (Ref.) |
 Any | 135 | 1609 | 10.5 | 1.26 (0.95,1.67) | 0.89 (0.68,1.17) |
  New | 34 | 355 | 12.8 | 1.54 (1.02,2.33) | 1.14 (0.79,1.63) |
  Discontinuing | 11 | 220 | 5.6 | 0.68 (0.36,1.27) | 0.36 (0.19,0.69) |
  Recurrent | 90 | 1033 | 10.7 | 1.29 (0.95,1.75) | 0.95 (0.71,1.28) |
ACB sum score | |||||
 Total ACB score (per point) | 1.07 (1.03,1.13) | 1.00 (0.94,1.06) | |||
 ACB12 score (per point) | 1.06 (1.00,1.13) | 0.97 (0.90,1.04) | |||
 ACB3 score (per point) | 1.10 (1.02,1.19) | 1.06 (0.98, 1.15) |