Table 6 Results: secondary outcomes
Secondary endpoints | |||||
|---|---|---|---|---|---|
Effect size dcohen | |||||
t0 | t1 | t2 | t2- t0 | ||
MMSE-score M ± SD (n = 81) | 17.4 ± 9.3 | 16.4 ± 10.0 | 16.6 ± 9.6 | 0.08 | |
DSS-score M ± SD (n = 80) | 4.7 ± 4.3 | 5.2 ± 4.3 | 5.6 ± 4.8 | 0.19 | |
TUG-time (sec) M ± SD (n = 34) | 30.3 ± 16.9 | 32.3 ± 19.8 | 29.5 ± 12.9 | 0.07 | |
CMAI-D signs of agitation % (n = 31) | 83.9 | 83.9 | 67.8 | ||
Apathy % | 25.8 | 29.0 | 38.7 | ||
DOS signs of delirium % (n = 62) | 58.1 | 62.9 | 59.7 | ||
Number of drugs per NHR M ± SD (n = 83) | 11.0 ± 5.3 | 11.5 ± 5.1 | 11.3 ± 4.7 | 0.06 | |
Min - Max | 1–29 | 3–28 | 4–24 | ||
Regular prescriptions per NHR M ± SD | 8.2 ± 4.2 | 8.5 ± 4.1 | 8.5 ± 4.1 | 0.07 | |
“As needed” prescriptions per NHR M ± SD | 2.7 ± 2.0 | 3.1 ± 1.9 | 2.8 ± 1.6 | 0.04 | |
NHRs with ≥5 drugs % | 79.5 | 80.7 | 83.1 | ||
NHRs with ≥10 drugs % | 37.4 | 37.4 | 37.4 | ||
S-DDIs per NHR M ± SD (n = 83) | 0.18 ± 0.47 | 0.19 ± 0.50 | 0.27 ± 0.60 | 0.17 | |
% NHRs with ≥1 S-DDIs | 14.4 | 14.4 | 20.5 | ||
Analgesics MAI-Sum (n = 52) (ATC classes M01, N02A, N02B) | M ± SD | 2.4 ± 3.4 | 1.3 ± 1.9 | 1.2 ± 1.8 | 0.45 |
MD (IQR) | 1.0 (0.0–3.8) | 0.0 (0.0–2.0) | 0.0 (0.0–2.0) | ||
Analgesics MAI-Mean (n = 52) (ATC classes M01, N02A, N02B) | M ± SD | 1.3 ± 2.0 | 0.6 ± 0.8 | 0.6 ± 0.9 | 0.46 |
MD (IQR) | 0.5 (0.0–2.0) | 0.0 (0.0–1.0) | 0.0 (0.0–.90) | ||