Primary endpoint: Descriptive results by ATC-class level 2 | ||||
---|---|---|---|---|
n = 83 | MAI-Sum M ± SD (n) | Mean difference | ||
ATC-class level 2 a | t0 | t1 | t2 | t2- t0 |
A02 – Drugs for acid related disorders | 5.4 ± 3.8 (44) | 3.4 ± 2.8 (45) | 2.7 ± 2.5 (44) | −2.7 b |
A06 – Laxatives | 1.1 ± 2.1 (74) | 0.4 ± 1.0 (79) | 0.4 ± 0.9 (87) | −0.7 |
A07 – Antidiarrheals, intestinal antiinflammatory/antiinfective agents | 1.5 ± 2.8 (15) | 0.9 ± 1.8 (15) | 0.5 ± 1.5 (11) | −1.0 b |
A10 – Drugs used in diabetes | 2.3 ± 3.3 (23) | 2.6 ± 3.6 (27) | 0.9 ± 1.9 (24) | −1.4 b |
A11 – Vitamins | 3.3 ± 2.5 (24) | 2.4 ± 2.8 (31) | 2.7 ± 3.2 (36) | −0.6 |
B01 – Antithrombotic agents | 1.4 ± 2.4 (54) | 1.1 ± 2.0 (56) | 0.9 ± 2.0 (57) | −0.5 |
B03 – Antianemic preparations | 2.2 ± 2.9 (13) | 1.9 ± 2.6 (17) | 2.2 ± 4.5 (19) | 0.0 |
C01 – Cardiac therapy | 3.1 ± 2.5 (18) | 1.3 ± 1.9 (18) | 0.5 ± 0.9 (17) | −2.5 b |
C03 – Diuretics | 1.7 ± 2.3 (51) | 1.5 ± 2.2 (52) | 1.4 ± 2.4 (51) | −0.3 |
C07 – Beta blocking agents | 1.2 ± 1.8 (40) | 1.5 ± 1.8 (37) | 1.0 ± 1.5 (37) | −0.2 |
C08 – Calcium channel blockers | 2.0 ± 2.7 (23) | 1.5 ± 2.3 (23) | 1.2 ± 1.7 (24) | −0.8 |
C09 – Agents acting on the renin-angiotensin system | 0.9 ± 1.2 (40) | 0.8 ± 1.2 (40) | 0.5 ± 1.1 (40) | −0.4 |
C10 – Lipid modifying agents | 1.1 ± 1.8 (25) | 0.7 ± 1.4 (22) | 0.5 ± 1.3 (22) | −0.6 |
D01 – Antifungals for dermatological use | 5.7 ± 6.0 (19) | 3.8 ± 4.4 (13) | 2.4 ± 3.9 (10) | −3.3 b |
D07 – Corticosteroids, dermatological preparations | 4.6 ± 4.1 (14) | 4.8 ± 2.9 (14) | 3.9 ± 3.4 (12) | −0.7 |
G04 – Urologicals | 2.0 ± 2.7 (12) | 2.2 ± 1.9 (9) | 2.0 ± 2.5 (8) | 0.0 |
H03 – Thyroid therapy | 2.8 ± 2.7 (22) | 2.5 ± 2.5 (22) | 2.4 ± 3.0 (22) | −0.4 |
M01 – Antiinflammatory and antirheumatic products | 3.2 ± 3.3 (13) | 1.0 ± 1.2 (11) | 1.7 ± 2.9 (7) | −1.5b |
N02 – Analgesics | 1.5 ± 2.5 (94) | 1.1 ± 1.7 (109) | 0.8 ± 1.3 (99) | −0.7 |
N03 – Antiepileptics | 1.1 ± 1.6 (20) | 2.2 ± 2.2 (19) | 2.4 ± 2.6 (21) | 1.2 c |
N04 – Anti-Parkinson drugs | 3.4 ± 2.3 (21) | 5.4 ± 4.8 (27) | 3.6 ± 4.8 (27) | 0.3 |
N05 – Psycholeptics | 6.0 ± 5.7 (80) | 4.4 ± 4.7 (89) | 3.8 ± 4.7 (84) | −2.2 b |
N06 – Psychoanaleptics | 2.1 ± 2.2 (50) | 2.8 ± 2.4 (43) | 2.6 ± 2.5 (48) | 0.5 |
R03 – Anti-asthmatics | 7.8 ± 13.4 (26) | 3.4 ± 3.6 (29) | 2.7 ± 4.7 (26) | −5.1 b |
S01 – Ophthalmologicals | 4.9 ± 6.3 (27) | 3.5 ± 2.9 (18) | 3.0 ± 3.8 (22) | −1.9 b |