Skip to main content

Table 3 Results: primary outcome

From: Impact of training and structured medication review on medication appropriateness and patient-related outcomes in nursing homes: results from the interventional study InTherAKT

Primary endpoint: Medication Appropriateness Index (MAI)

 n = 83

Mean difference (MAI change) [CI95%]

Effect size dcohen [CI95%]

p-value (1-tailed)

 

t0

t1

t2

t2- t0

t2- t0

t2- t0

  MAI-Sum

M ± SD

23.2 ± 22.5

18.3 ± 13.1

16.1 ± 12.7

-7.1 [−11.4 – −2.8]

−0.39 [− 0.82–0.05]

0.001

MD (IQR)

18.0 (9.0–32.0)

16.0 (9.0–27.1)

13.0 (7.0–26.0)

−3.0 (− 13.0–2.0)

  Subgroup

MAI-Sum ≥24 at t0 (n = 31)

M ± SD

43.2 ± 25.5

29.8 ± 11.7

25.8 ± 12.9

−17.4 [−27.6 – −7.2]

−0.86 [− 1.60 – − 0.13]

0.001

MD (IQR)

36.0 (30.0–45.0)

30.0 (19.0–36.0)

26.0 (14.0–34.0)

− 15.0 (− 25.0 – − 2.0)

MAI-Sum < 24 at t0 (n = 52)

M ± SD

11.2 ± 6.7

11.4 ± 8.3

10.3 ± 8.4

−0.9 [−3.2–1.3]

−0.12 [− 0.67–0.42]

0.197

MD (IQR)

11.0 (7.0–16.8)

11.0 (4.5–17.0)

9.0 (5.0–14.0)

− 1.0 (− 5.0–2.0)

  MAI-Mean

M ± SD

1.9 ± 1.2

1.5 ± 0.9

1.3 ± 0.8

−0.6 [− 0.8 – − 0.4]

−0.61 [− 1.05 – − 0.17]

0.000

MD (IQR)

1.8 (1.2–2.6)

1.5 (1.0–2.0)

1.3 (0.8–1.8)

− 0.3 (− 1.3–0.1)

Pearson correlation between MAI sum-score at t0 and mean difference t2- t0: r = −  0.83

 n = 81 a

Mean difference (MAI change) [CI95%]

Effect size dcohen [CI95%]

p-value

(1-tailed)

 

t0

t1

t2

t2- t0

t2- t0

t2- t0

  MAI-Sum

M ± SD

20.5 ± 14.6

17.9 ± 13.0

15.8 ± 12.7

−4.7 [−7.5 – −1.9]

−0.35 [− 0.78–0.09]

0.001

MD (IQR)

17.0 (9.0–30.5)

16.0 (8.5–26.0)

12.0 (7.0–22.5)

− 3.0 (− 12.0–2.0)

  Subgroup

MAI-Sum ≥24 at t0 (n = 29)

M ± SD

37.1 ± 9.2

29.4 ± 12.0

25.6 ± 13.3

−11.5 [− 17.8 – −5.3]

−1.00 [− 1.77 – − 0.23]

0.000

MD (IQR)

34.0 (29.5–42.0)

29.0 (19.0–36.0)

26.0 (14.0–34.0)

− 14.0 (− 22.0 – − 0.5)

MAI-Sum < 24 at t0 (n = 52)

M ± SD

11.2 ± 6.7

11.4 ± 8.3

10.3 ± 8.4

−0.9 [−3.2–1.3]

−0.12 [− 0.67–0.42]

0.197

MD (IQR)

11.0 (7.0–16.8)

11.0 (4.5–17.0)

9.0 (5.0–14.0)

− 1.0 (− 5.0–2.0)

Linear regression to predict the mean difference t 2 - t 0 (MAI-change) by MAI-Sum at t 0 :

ß = −  0.57 (p = .000), R2 = 0.33 (p = 0.000)

  1. M Mean, SD Standard deviation, MD Median, IQR Inter-Quartile-Range, MAI-Sum Weighted MAI sum-score, MAI-Mean Weighted MAI mean-score
  2. a To additionally depict the mean more adequately, two outliers with high baseline sum-scores/change values > 4 SD greater than the mean and high baseline numbers of drugs/marked drops in drug count were excluded
Back to article page

BMC Geriatrics

ISSN: 1471-2318

Contact us