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Table 4 Sensitivity, specificity and positive predictive values (PPV) at different prevalence rates of optimal cut off ACE-III, HDS-R, and MMSE scores for identifying MCI and dementia (Values in parentheses represent the respective negative predictive value)

From: Validation of Addenbrooke’s cognitive examination III for detecting mild cognitive impairment and dementia in Japan

TEST CUT-OFF MCI PPV at different prevalence rates
  SCORE SENSITIVITY SPECIFICITY 5% 10% 20% 40%
ACE-III 88/89 0.77 0.92 0.35 (0.99) 0.52 (0.97) 0.72 (0.94) 0.87 (0.86)
HDS-R 24/25 0.57 0.89 0.22 (0.98) 0.37 (0.95) 0.57 (0.89) 0.78 (0.76)
MMSE 26/27 0.61 0.86 0.19 (0.98) 0.33 (0.95) 0.52 (0.90) 0.75 (0.77)
TEST CUT-OFF DEMENTIA PPV at different prevalence rates
  SCORE SENSITIVITY SPECIFICITY 5% 10% 20% 40%
ACE-III 75/76 0.82 0.90 0.30 (0.99) 0.48 (0.98) 0.67 (0.95) 0.85 (0.88)
HDS-R 20/21 0.67 0.89 0.24 (0.98) 0.39 (0.96) 0.59 (0.91) 0.80 (0.80)
MMSE 23/24 0.64 0.87 0.21 (0.98) 0.36 (0.96) 0.55 (0.91) 0.77 (0.78)
  1. ACE-III Addenbrooke’s Cognitive Examination-III, HDS-R Hasegawa Dementia Scale-revised, MMSE Mini-mental State Examination