Table 3 Participants taking renal risk drugs (requiring dose adjustment or drug that should be avoided; total number of subjects 4514)
Name of drug | Total population; n (%) | CC | sMDRD | Appropriate by sMDRD but inappropriate by CC (n; % of all patients taking particular drug) | ||||
|---|---|---|---|---|---|---|---|---|
Potentially inappropriate use; n (% of subjects with CC below level indicated in recommendations) | Renally appropriate use; n (% of subjects with CC above level indicated in recommendations) | Potentially inappropriate use; % of all patients taking particular drug | Potentially inappropriate use; n (% of subjects with sMDRD below level indicated in recommendations) | Renally appropriate use; n (% of subjects with sMDRD above level indicated in recommendations) | Potentially inappropriate use; % of all patients taking particular drug | |||
Drugs that should be avoided | ||||||||
Metoclopramide | 20 (0.44) | 4 (0.74) | 16 (0.40) | 20.00% | 1 (0.62) | 19 (0.44) | 5.00% | 3 (15.0) |
Metformin | 292 (6.47) | 64 (3.69)* | 228 (8.20) | 21.92% | 59 (6.90) | 233 (6.37) | 20.20% | 24 (8.2) |
Acarbose | 39 (0.86) | 2 (2.00) | 37 (0.84) | 5.13% | 1 (4.35) | 38 (0.85) | 2.56% | 1 (2.6) |
Sotalol | 63 (1.40) | 4 (0.74) | 59 (1.49) | 6.35% | 1 (0.62) | 62 (1.42) | 1.59% | 3 (4.8) |
Amiloride | 126 (2.79) | 13 (6.44)* | 113 (2.62) | 10.32% | 4 (4.26) | 122 (2.76) | 3.17% | 12 (9.5) |
Spironolactone | 330 (7.31) | 35 (17.50)* | 295 (6.84) | 10.61% | 11 (20.37)* | 319 (7.15) | 3.33% | 25 (7.6) |
Hydrochlorothiazide | 265 (5.87) | 22 (11.00)* | 243 (5.64) | 8.30% | 6 (11.11) | 259 (5.81) | 2.26% | 18 (6.8) |
NSAIDs& | 525 (11.63) | 122 (11.31) | 403 (11.74) | 23.24% | 55 (13.41) | 470 (11.45) | 10.48% | 73 (13.9) |
Meloxicam and nimesulide | 108 (2.39) | 25 (2.32) | 83 (2.42) | 23.15% | 11 (2.68) | 97 (2.36) | 10.18% | 15 (13.9) |
Alendronic acid | 20 (0.44) | 2 (0.59) | 18 (0.43) | 10.00% | 0 | 20 (0.45) | 0% | 2 (10.00) |
Drugs requiring dose adjustment | ||||||||
Ranitidine | 100 (2.22) | 42 (3.89)* | 58 (1.69) | 42.00% | 15 (3.66)* | 85 (2.07) | 15.00% | 28 (28.0) |
Gliclazide | 197 (4.36) | 56 (5.19) | 141 (4.11) | 28.43% | 28 (6.83)* | 169 (4.12) | 14.21% | 32 (16.2) |
Digoxin | 204 (4.52) | 95 (8.80)* | 109 (3.18) | 46.57% | 34 (8.29)* | 170 (4.14) | 16.67% | 63 (30.9) |
Atenolol | 56 (1.24) | 5 (1.48) | 51 (1.22) | 8.93% | 4 (4.12)* | 52 (1.18) | 7.14% | 1 (1.8) |
Fenofibrate | 61 (1.35) | 24 (1.38) | 37 (1.33) | 39.34% | 24 (2.81)* | 37 (1.01) | 39.34% | 4 (6.6) |
Tramadol | 81 (1.79) | 3 (1.50) | 78 (1.81) | 3.70% | 0 | 81 (1.82) | 0% | 2 (2.5) |
Piracetam | 342 (7.58) | 128 (11.86)* | 214 (6.23) | 37.43% | 57 (13.90)* | 285 (6.94) | 16.67% | 77 (22.5) |
Cetirizine | 38 (0.84) | 0 | 38 (0.88) | 0% | 0 | 38 (0.85) | 0% | 0 |