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Table 3 Prevalence of pre-specified comorbidities for Alzheimer’s disease and matched cohorts

From: Retrospective assessment of patient characteristics and healthcare costs prior to a diagnosis of Alzheimer’s disease in an administrative claims database

Comorbidity, n (%) AD (n = 16,494) Matched Cohort (No AD or Dementia) (n = 49,482) P value*
Hypertension 14,816 (89.8) 43,198 (87.4) < 0.001
Dyslipidemia 13,951(84.6) 41,824 (84.6) 0.986
Other forms of heart disease 9434(57.2) 23,597 (47.7) < 0.001
Osteoarthritis 8372 (50.8) 23,389 (47.3) < 0.001
Urinary tract infection 8146 (49.4) 17,096 (34.6) < 0.001
Cerebrovascular disease 7207 (43.7) 11,479 (23.2) < 0.001
Ischemic heart disease 6963 (42.2) 17,841(36.1) < 0.001
Diabetes 6866 (41.6) 18,698 (37.8) < 0.001
Mood disorder 6483 (39.3) 8391 (17.0) < 0.001
Osteoporosis 5788 (35.1) 16,325(33.0) < 0.001
Any chronic obstructive pulmonary disease 5728 (34.7) 15,405(31.2) < 0.001
Acute respiratory infection 5137 (31.1) 16,576 (33.5) < 0.001
Cancer 4390 (26.6) 14,271(28.9) < 0.001
Anxiety disorder 4356 (26.4) 7428(15.0) < 0.001
Heart failure 3957(24.0) 8907(18.0) < 0.001
Peripheral vascular disease 3547 (21.5) 8155 (16.5) < 0.001
Atherosclerosis 3435(20.8) 8615(17.4) < 0.001
Pneumonia 2931(17.8) 5506 (11.1) < 0.001
Insomnia 2132(12.9) 4704(9.5) < 0.001
Mild Cognitive Impairment 1727(10.5) 0(0.0) < 0.001
Diseases of pulmonary circulation 1689 (10.2) 4248 (8.6) < 0.001
Chronic ulcer of skin 1505(9.1) 2486 (5.0) < 0.001
Behavioral disturbance 1369(8.3) 0 (0.0) < 0.001
Venous Thromboembolism 969(5.9) 1999 (4.0) < 0.001
Parkinson’s disease 872(5.3) 568 (1.1) < 0.001
Gastric, duodenal, peptic, or gastrojejunal ulcer 854(5.2) 1710(3.5) < 0.001
Epilepsy 845(5.1) 688(1.4) < 0.001
Rheumatoid arthritis 771(4.7) 2155 (4.4) 0.087
Lung cancer 233(1.4) 720 (1.5) 0.686
  1. Abbreviations: AD Alzheimer’s disease, MCI Mild Cognitive Impairment
  2. *Chi square test used; Significance level set at P < 0.05