Table 3 Prevalence of pre-specified comorbidities for Alzheimer’s disease and matched cohorts
Comorbidity, n (%) | AD (n = 16,494) | Matched Cohort (No AD or Dementia) (n = 49,482) | P value* |
|---|---|---|---|
Hypertension | 14,816 (89.8) | 43,198 (87.4) | < 0.001 |
Dyslipidemia | 13,951(84.6) | 41,824 (84.6) | 0.986 |
Other forms of heart disease | 9434(57.2) | 23,597 (47.7) | < 0.001 |
Osteoarthritis | 8372 (50.8) | 23,389 (47.3) | < 0.001 |
Urinary tract infection | 8146 (49.4) | 17,096 (34.6) | < 0.001 |
Cerebrovascular disease | 7207 (43.7) | 11,479 (23.2) | < 0.001 |
Ischemic heart disease | 6963 (42.2) | 17,841(36.1) | < 0.001 |
Diabetes | 6866 (41.6) | 18,698 (37.8) | < 0.001 |
Mood disorder | 6483 (39.3) | 8391 (17.0) | < 0.001 |
Osteoporosis | 5788 (35.1) | 16,325(33.0) | < 0.001 |
Any chronic obstructive pulmonary disease | 5728 (34.7) | 15,405(31.2) | < 0.001 |
Acute respiratory infection | 5137 (31.1) | 16,576 (33.5) | < 0.001 |
Cancer | 4390 (26.6) | 14,271(28.9) | < 0.001 |
Anxiety disorder | 4356 (26.4) | 7428(15.0) | < 0.001 |
Heart failure | 3957(24.0) | 8907(18.0) | < 0.001 |
Peripheral vascular disease | 3547 (21.5) | 8155 (16.5) | < 0.001 |
Atherosclerosis | 3435(20.8) | 8615(17.4) | < 0.001 |
Pneumonia | 2931(17.8) | 5506 (11.1) | < 0.001 |
Insomnia | 2132(12.9) | 4704(9.5) | < 0.001 |
Mild Cognitive Impairment | 1727(10.5) | 0(0.0) | < 0.001 |
Diseases of pulmonary circulation | 1689 (10.2) | 4248 (8.6) | < 0.001 |
Chronic ulcer of skin | 1505(9.1) | 2486 (5.0) | < 0.001 |
Behavioral disturbance | 1369(8.3) | 0 (0.0) | < 0.001 |
Venous Thromboembolism | 969(5.9) | 1999 (4.0) | < 0.001 |
Parkinson’s disease | 872(5.3) | 568 (1.1) | < 0.001 |
Gastric, duodenal, peptic, or gastrojejunal ulcer | 854(5.2) | 1710(3.5) | < 0.001 |
Epilepsy | 845(5.1) | 688(1.4) | < 0.001 |
Rheumatoid arthritis | 771(4.7) | 2155 (4.4) | 0.087 |
Lung cancer | 233(1.4) | 720 (1.5) | 0.686 |