Age dependency of risk factors for cognitive decline

BMC Geriatrics

Table 2 The association of risk factors with cognitive decline in the total sample

Risk factor	MMSE			15WT immediate recall			15WT delayed recall
Risk factor	B	SE	P-value	B	SE	P-value	B	SE	P-value
APOE ε4	−0.25	0.24	< 0.01	−0.07	1.27	0.49	−0.09	1.44	0.42
Total cholesterol	0.05	0.17	0.34	0.09	1.22	0.11	0.08	1.39	0.21
LDL cholesterol	0.05	0.17	0.41	0.08	1.24	0.20	0.08	1.41	0.25
HDL cholesterol	0.16	0.16	0.20	0.23	1.21	0.08	0.07	1.42	0.67
Homocysteine	−0.05	0.12	< 0.01	−0.05	1.16	< 0.01	− 0.06	1.33	< 0.01
Hypertension	0.13	0.28	0.26	−0.02	1.26	0.88	−0.03	1.43	0.85
DM	−0.16	0.29	0.25	−0.42	1.28	0.01	−0.42	1.45	0.04
MI	0.05	0.29	0.69	0.08	1.28	0.58	0.22	1.48	0.21
Stroke	−0.40	0.28	0.02	−0.55	1.27	0.01	−0.58	1.44	0.02
Depressive symptoms	−0.01	0.33	< 0.01	−0.02	1.33	< 0.01	−0.02	1.50	< 0.01
CRP	0.00	0.27	0.57	−0.01	1.27	0.15	−0.01	1.45	0.47
IL-6	0.01	0.26	0.46	0.01	1.27	0.72	0.02	1.44	0.42
ACT	0.00	0.27	0.68	0.00	1.27	0.74	0.00	1.45	0.87
Alcohol^a: minimal^b	0.27	0.10	< 0.01	0.35	0.12	< 0.01	0.35	0.14	0.01
Alcohol^a: moderate^c	0.24	0.08	< 0.01	0.41	0.10	< 0.01	0.42	0.12	< 0.01
Smoking	−0.09	0.25	0.26	−0.16	1.27	0.09	−0.03	1.46	0.77
Physical activity	0.00	0.30	0.78	0.00	1.28	0.59	0.00	1.45	0.24

B’s are determined by linear mixed models in combination with splines and adjusted for sex and education
15WT 15 Words Test, ACT a1-antichymotrypsin, APOE apolipoprotein E, CRP C-reactive protein, DM Diabetes mellitus, HDL High-Density Lipoprotein, IL-6 interleukin-6, LDL Low-Density Lipoprotein, MI Myocardial infarction, MMSE Mini-Mental State Examination
^aNo alcohol use is reference group. ^bWomen:1 drink/day, men: 1–2 drinks/day. ^cWomen: > 1 drink/day, men: > 2 drinks/day

ISSN: 1471-2318