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Table 2 Cox regression analyses for the 30-day primary endpoint (all-cause death or HF-related rehospitalization)

From: Predictive biomarkers for death and rehospitalization in comorbid frail elderly heart failure patients

 

30-day composite endpoint

 

Univariate analysis

Multivariate analysis

 

HR

95%CI

p-value

HR

95%CI

p-value

Age

1.03

0.99–1.07

0.2

–

–

–

Female sex

1.54

0.83–2.87

0.2

2.28

1.19–4.37

0.01

NYHA

1.08

0.63–1.87

0.8

   

Diabetes

1.59

1.11–2.56

0.01

–

–

–

Charlson comorbidity index

1.28

1.14–1.44

< 0.001

1.26

1.11–1.43

< 0.001

Barthel index

0.99

0.98–1.00

0.008

–

–

–

Urea

1.01

1.00–1.01

< 0.05

–

–

–

Creatinine

0.99

0.93–1.06

0.7

   

Hb

0.93

0.77–1.11

0.4

   

Na

1.05

0.97–1.14

0.2

   

NT-proBNPa

1.63

1.21–2.19

0.001

–

–

–

ST2a

1.67

1.33–2.11

< 0.001

1.53

1.19–1.97

0.001

CA125a

1.12

0.83–1.51

0.5

   

Hs-TnIa

1.23

0.92–1.63

0.2

   
  1. aLog-transformed and per 1 SD
  2. CA125 cancer antigen 125, NT-proBNP N-terminal pro-brain natriuretic peptide, hs-TnI high-sensitivity troponin I, ST2 Interleukin-1 receptor-like 1
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