Table 2 Mean baseline and 6-month scores for cognitive function and brain MRI and the mean within group changes and net between groups differences for the change over time
Outcome | ART group | Control Group | Between-group differencea | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Baseline | 6-months | Change | Baseline | 6-months | Change | |||||||||
Mean (SE) | Mean (SE) | Mean (95% CI) | Mean (SE) | Mean (SE) | Mean (95%CI) | Mean (95% CI) | ||||||||
Cognitive global score | 0.06 | 0.11 | 0.20 | 0.11 | 0.14 | 0.02,0.27 | −0.06 | 0.12 | −0.08 | 0.12 | −0.01 | −0.14,0.12 | 0.16 | −0.02, 0.34 |
RCF copy | 27.6 | 0.9 | 27.4 | 0.9 | −0.2 | −1.8, 1.5 | 26.2 | 0.9 | 25.9 | 0.9 | −0.3 | −2.03,1.4 | 0.2 | −2.1, 2.6 |
RCF delay | 14.8 | 1.0 | 16.0 | 1.0 | 1.3 | −0.2, 2.8 | 13.9 | 1.0 | 15.5 | 1.00 | 1.6 | 0.03, 3.1 | −0.3 | −2.5, 1.8 |
Stroop C-D | 16.7 | 1.8 | 12.9 | 1.9 | −3.8 | −7.1, −0.5 | 20.1 | 1.9 | 18.3 | 1.9 | −1.8 | −5.1, 1.6 | −2.1 | −6.7, 2.6 |
Trails B-A | 40.2 | 4.5 | 31.5 | 4.7 | −8.7 | −17.9,0.5 | 38.2 | 4.7 | 33.8 | 4.8 | −4.3 | −13.8,5.1 | −4.4 | −17.7, 9.0 |
DSC | 58.6 | 2.6 | 60.8 | 2.6 | 2.2 | 0.2, 4.2 | 56.1 | 2.7 | 56.1 | 2.7 | 0.0 | −2.1,2.1 | 2.3 | −0.6, 5.2 |
Digit span | 19.2 | 0.7 | 18.2 | 0.7 | −1.0 | −1.9,-0.1 | 19.9 | 0.7 | 20.6 | 0.7 | 0.7 | −0.2,1.6 | −1.7 | −3.0, −0.5 |
Hopkins I | 26.1 | 0.9 | 26.8 | 0.9 | 0.7 | −0.9,2.2 | 27.0 | 0.9 | 27.3 | 1.0 | 0.3 | 0.-1.3,1.9 | 0.4 | −1.9, 2.7 |
Hopkins D | 9.4 | 0.4 | 9.5 | 0.5 | 0.1 | −0.7,0.9 | 9.0 | 0.5 | 9.2 | 0.5 | 0.2 | −0.6, 1.0 | −0.1 | −1.2, 1.0 |
Hopkins R | 10.7 | 0.2 | 10.5 | 0.2 | −0.2 | −0.7,0.4 | 10.7 | 0.2 | 10.1 | 0.2 | −0.6 | −1.1,-0.0 | 0.5 | −0.3, 1.2 |
COWAT word | 40.7 | 2.5 | 43.7 | 2.5 | 3.1 | 0.4,5.7 | 38.3 | 2.6 | 39.7 | 2.6 | 1.4 | −1.3,4.1 | 1.7 | −2.0, 5.4 |
COWAT Category | 21.0 | 0.9 | 20.1 | 0.9 | −0.9 | −2.6,0.8 | 18.7 | 1.0 | 19.3 | 1.0 | 0.6 | −1.1,2.4 | −1.5 | −3.9, 1.0 |
MRI brain | ||||||||||||||
Total brain | 1128.5 | 28.6 | 1130.1 | 28.6 | 1.6 | −2.3,5.5 | 1176.14 | 28.55 | 1175.7 | 28.6 | −0.5 | −4.4,3.4 | 1.9 | −3.7,7.4 |
White matter | 742.2 | 34.7 | 741.1 | 34.7 | −1.1 | −9.9,7.7 | 814.46 | 34.66 | 808.7 | 34.7 | −5.8 | −14.6,3.1 | 4.3 | −8.4,17.0 |
C-thickness | 3.8 | 0.1 | 3.8 | 0.1 | 0.0 | −0.1,1.1 | 3.43 | 0.13 | 3.5 | 0.1 | 0.1 | −0.0,0.2 | −0.0 | −0.2,0.1 |
Hippocampal | 6.9 | 0.1 | 7.0 | 0.1 | 0.10 | −0.01,0.20 | 7.2 | 0.14 | 7.1 | 0.1 | −0.02 | −0.12,0.08 | 0.13 | −0.03, 0.29 |
White FA | 0.408 | 0.004 | 0.412 | 0.004 | 0.002 | −0.002,0.006 | 0.406 | 0.004 | 0.399 | .005 | −0.007 | −0.012,-0.003 | 0.009 | 0.003, 0.016 |
White MD | 0.001 | 0.000 | 0.001 | 0.000 | −0.000 | −0.000,0.000 | 0.001 | 0.000 | 0.001 | 0.000 | −0.000 | −0.000,0.000 | −0.000 | 0.000,0.000 |