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Table 1 Characteristics according to three groups based on vitamin D level and supplement use

From: Vitamin D supplementation as a potential cause of U-shaped associations between vitamin D levels and negative health outcomes: a decision tree analysis for risk of frailty

 

Entire cohort

Supplement users

Non-users (n = 152)

  
 

N = 238

n = 86 (36.1%)

Low vitamin D (<18 ng/mL) n = 55 (23.1%)

High vitamin D (> = 18 ng/mL) n = 97 (40.8%)

p value

Frailty Index

0.39 ± 0.13

0.43 ± 0.11

0.41 ± 0.13

0.35 ± 0.13

<0.001

Frailty (FI > =0.25)

208 (87.4%)

84 (97.7%)

50 (90.9%)

74 (76.3%)

<0.001

25 (OH) D (ng/mL)

 Mean

23.4 ± 9.8

26.6 ± 9.3

11.7 ± 3.8

27.1 ± 7.0

<0.001

 Range

4–53

6–52

4–17

18–53

 

 < 20 ng/mL

89 (37.4%)

19 (22.1%)

55 (100.0%)

15 (15.5%)

<0.001

Age

73.4 ± 13.1

79.0 ± 11.7

67.4 ± 12.1

71.9 ± 13.0

<0.001

Body mass index

26.5 ± 6.7

25.1 ± 6.0

29.5 ± 8.5

26.0 ± 5.5

<0.001

Education (year)

13.0 ± 2.3

13.0 ± 2.4

13.0 ± 3.0

13.0 ± 2.3

1.00

Ethnicity

 White

117 (49.2%)

41 (47.7%)

21 (38.2%)

55 (56.7%)

0.03

 Asian/Pacific Islander

102 (42.9%)

41 (47.7%)

30 (54.5%)

31 (32.0%)

 

 Others

18 (7.6%)

3 (3.5%)

4 (7.3%)

11 (11.3%)

 

Smoking

 Never

80 (33.6%)

27 (31.4%)

13 (23.6%)

40 (41.2%)

0.10

 Past

120 (50.4%)

49 (57.0%)

30 (54.5%)

41 (42.3%)

 

 Current

38 (16.0%)

10 (11.6%)

12 (21.8%)

16 (16.5%)

 

Alcohol

 Never

100 (42.0%)

39 (45.3%)

20 (36.4%)

41 (42.3%)

0.73

 Past

83 (34.9%)

30 (34.9%)

22 (40.0%)

31 (32.0%)

 

 Current

55 (23.1%)

17 (19.8%)

13 (23.6%)

25 (25.8%)

 

Reason for admission

 Rehabilitation

86 (36.1%)

26 (30.2%)

24 (43.6%)

36 (37.1%)

0.001

 Skilled-nursing care

49 (20.6%)

7 (8.1%)

15 (27.3%)

27 (27.8%)

 

 Intermediate care

8 (3.4%)

4 (4.7%)

1 (1.8%)

3 (3.1%)

 

 Respite

95 (39.9%)

49 (57.0%)

15 (27.3%)

31 (32.0%)

 

Place veterans came from

 Home

101 (42.4%)

54 (62.8%)

15 (27.3%)

32 (33.0%)

<0.001

 Acute care

128 (53.8%)

28 (32.6%)

38 (69.1%)

62 (63.9%)

 

 Other nursing home

9 (3.8%)

4 (4.7%)

2 (3.6%)

3 (3.1%)

 

Season of admission

 Winter

62 (26.1%)

23 (37.1%)

13 (21.0%)

26 (41.9%)

0.83

 Spring

55 (23.1%)

18 (32.7%)

16 (29.1%)

21 (38.2%)

 

 Summer

62 (26.1%)

20 (32.3%)

14 (22.6%)

28 (45.2%)

 

 Autumn

59 (24.8%)

25 (42.4%)

12 (20.3%)

22 (37.3%)

 

Correlation between FI and 25 (OH) Da

−0.10 p = 0.13

−0.05 p = 0.63

−0.19 p = 0.02

 

Relative risk of frailty, OR (95% CI)

1.0 (ref)

1.12 (1.05–1.18) p < 0.001

1.04 (0.94–1.15) p = 0.42

0.87 (0.77–0.99) p = 0.03

 
  1. Analysis of variance for continuous variables and chi-square test for categorical variables mean ± Standard deviation, n (%)
  2. 25 (OH) D 25-hydroxyvitamin D level, 95%CI 95% confidence interval, FI Frailty Index, OR Odds ratio
  3. aSpearman’s correlation coefficient in supplement users and non-users