A multi-center, randomized, controlled trial to assess the efficacy of optimization of drug prescribing in an elderly population, at 18 months of follow-up, in the evolution of functional autonomy: the OPTIM study protocol

Table 1 Schedule of enrolment, intervention and assessments of the OPTIM study

	Study Period
	Enrolment	Allocation	Follow-up
Timepoint	- t1	0	t ₁ : 1 month	t ₂: 6 months	t ₃: 18 months - Close-out
Enrolment:
Eligibility screen	X
Information to patients/careviger	X
Collection of non-opposition to participate	X
Randomized allocation		X
Intervention:
(1) Intervention: Optimization of drug prescribing		X	X	X
(2) Control
Assessments:
Collected in patient record: * Sociodemographic data * Diagnosis and stage * Current comorbidities, history of comorbidities, lifestyle habits * Biological exam and artrial pressure when available		X
Primary outcomes: * IADL scale * DAD-6 scale		X	X	X	X
Secondary outcomes: * MMSE (cognitive function) * mini-GDS (depression) * Hamilton scale (anxiety) * Pain scale * EUROQOL-5D (quality of life) * Girerd scale (compliance to drug prescribing) * Event and date of event: hospitalization, falls, recourse of emergency, institutionalization, death		X		X	X
Drugs prescribing		X	X	X	X

ISSN: 1471-2318