From: Thiazides in the management of hypertension in older adults – a systematic review
Source | Type of study | Selection bias | Performance bias | Detection bias | Attrition bias | Reporting bias | ||
---|---|---|---|---|---|---|---|---|
1. Random sequence generation | 2. Allocation concealment | 3. Blinding of participants and personnel | 4. Blinding of outcome assessment | 5. Incomplete outcome data | 6. Selective reporting | 7. Other bias | ||
ACCOMPLISH Jamerson et al. 2008 [40] | Multicentre trial in US and North Europe | UR | LR | LR | LR | LR | UR | UR |
ALLHAT 2002 [24] | double blind RCT | LR | LR | LR | LR | LR | LR | UR |
Chalmers et al. 2000 [28] | double blind RCT | UR | UR | LR | LR | LR | LR | UR |
EWPHE Amery et al. 1985 [31], Fletcher 1991 [32], Staessen et al. 1989 [33] Staessen et al. 1991 [34] | double blind RCT | LR | UR | LR | LR | HR | LR | UR |
HSCS 1974 [36] | double blind RCT | UR | UR | LR | UR | UR | LR | HR |
HYVET pilot Bulpitt et al. 2003 [39] | RCT | LR | LR | HR | HR | LR | LR | LR |
HYVET Beckett et al. 2008 [37] | double-blind RCT | LR | LR | LR | LR | UR | LR | LR |
Kuramoto et al. 1981 [41] | Prospective clinical trial | UR | UR | UR | UR | HR | LR | HR |
MRC-O trial 1992 [44] | single blind RCT | UR | UR | LR | LR | HR | UR | HR |
SHELL Malacco et al. 2003 [44] | RCT open design | LR | UR | HR | HR | HR | LR | HR |
SHEP pilot Hulley et al. 1985 [46] Perry et al. 1986 [47] Perry et al. 1989 [48] | double-blind RCT | LR | UR | LR | LR | HR | UR | UR |
SHEP SHEP Group 1991 [49], Hawkins 1993 [50], Perry et al. 2000 [51], Kostis et al. 1997 [52], Curb et al. 1996 [53], Savage et al. 1998 [58], Somes et al. 1999 [55] | double-blind RCT | LR | LR | LR | LR | LR | LR | UR |