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Table 3 Quality appraisal of included systematic reviews

From: Effectiveness and safety of vitamin K antagonists and new anticoagulants in the prevention of thromboembolism in atrial fibrillation in older adults – a systematic review of reviews and the development of recommendations to reduce inappropriate prescribing

Reference 1. Was an ‘a priori’ design provided? 2. Was there duplicate study selection and data extraction? 3. Was a comprehensive literature search performed? 4. Was the status of publication (i.e. grey literature) used as an inclusion criterion? 5. Was a list of studies (included and excluded) provided? 6. Were the characteristics of the included studies provided? 7. Was the scientific quality of the included studies assessed and documented? 8. Was the scientific quality of the included studies used appropriately in formulating conclusions? 9. Were the methods used to combine the findings of studies appropriate? 10. Was the likelihood of publication bias assessed? 11. Was the conflict of interest stated?
Adam et al. 2012 [31] yes yes yes no yes yes yes yes yes unclear yes
Agarwal et al. 2012 [27] unclear no yes no no yes yes yes yes yes no
Aguilar et al. 2005 [34] yes yes yes unclear yes yes yes yes yes no yes
Aguilar et al. 2007 [44] yes yes yes unclear yes yes yes yes yes no yes
Andersen et al. 2008 [37] yes yes yes no yes yes yes yes NA yes yes
Assiri et al. 2013 [42] yes unclear yes no no yes unclear unclear yes no yes
Baker et al. 2012 [53] yes yes yes yes no yes yes yes yes yes yes
Briceno et al. 2015 [29] yes unclear yes no no yes no unclear yes yes yes
Cameron et al. 2014 [46] yes yes yes yes yes yes no no yes no yes
Capodanno et al. 2013 [47] yes yes yes no no yes no no yes yes no
Chatterje et al. 2013 [63] yes yes yes no no yes yes yes yes yes yes
Coleman et al. 2012 [35] yes yes yes no yes yes yes yes yes yes no
Cooper et al. 2006 [41] yes no yes no no yes no unclear no no no
Dogliotti et al. 2013 [48] yes yes yes no no yes no no yes yes yes
Dogliotti et al. 2014 [40] yes yes yes no no yes no yes no no yes
Harenberg et al. 2012 [70] yes unclear yes no no yes no unclear yes no yes
Hart et al. 1999 [4] yes yes yes no no yes no unclear yes no no
Hart et al. 2007 [39] yes yes yes yes yes yes yes yes yes no yes
Holster et al. 2013 [33] yes yes yes unclear no no yes yes yes yes no
Jia et al. 2014 [54] yes unclear yes yes yes no no unclear yes no no
Lega et al. 2014 [30] yes yes yes yes yes no yes yes yes no yes
Liew et al. 2014 [49] yes yes yes unclear no no yes yes yes no yes
Lin et al. 2015 [43] yes yes yes yes yes yes yes no no yes yes
Lip et al. 2006 [36] yes no yes no no yes no unclear yes yes yes
Miller et al. 2012 [50] yes yes yes yes no yes no no yes no no
Providência et al. 2014 [51] yes yes yes yes unclear yes unclear unclear yes no yes
Rong et al. 2015 [66] yes unclear yes yes no yes yes yes yes no yes
Roskell et al. 2010 [67] NA yes yes no no no yes yes yes no yes
Ruff et al. 2014 [28] yes unclear no no no yes no unclear yes unclear yes
Sardar et al. 2013 [64] yes yes yes yes no yes yes yes yes yes yes
Sardar et al. 2014 [32] yes yes yes no no yes yes unclear yes yes yes
Schneeweiss et al. 2012 [69] yes unclear yes no no no no unclear yes no yes
Segal et al. 2000 [38] yes yes yes no yes yes yes yes yes no yes
Senoo et al. 2015 [65] yes unclear yes yes no yes yes yes yes no yes
Sharma et al. 2015 [26] yes yes yes yes no yes yes no yes yes yes
Taylor et al.2001 [45] yes unclear yes yes no yes unclear yes yes yes yes
Testa et al. 2012 [52] yes unclear yes no no unclear yes unclear yes no no
Verdecchia et al. 2015 [68] yes yes yes unclear no yes no unclear yes no yes
  1. NA not applicable