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Table 3 Association between cytokines and prevalent peripheral arterial disease (ABI <0.90)

From: Prevalent peripheral arterial disease and inflammatory burden

   Second quarter (25th - 50th percentile) Third quarter (50th -75th percentile) Fourth quarter (75th - 100th percentile) P for trend
Cytokine Model Odds Ratio, 95% Confidence Intervala
IL-6 Crude model 1.94 (0.65, 5.87) 3.63 (1.31, 10.01) 6.00 (2.27, 15.91) <0.001
Age-adjusted model 1.71 (0.57, 5.12) 3.13 (1.12, 8.71) 4.91 (1.83, 13.17) 0.001
Multivariate-adjusted modelb 1.37 (0.42, 4.46) 3.46 (1.19, 10.11) 3.95 (1.38, 11.26) 0.003
Multivariate-adjusted model + smoking status 1.32 (0.40, 4.31) 2.88 (0.98, 8.49) 2.90 (0.99, 8.52) 0.020
Multivariate-adjusted model + CVD risk factorsc 1.17 (0.34, 3.98) 3.39 (1.13,10.18) 3.57 (1.21, 10.50) 0.005
IL-6 SR Crude model 0.95 (0.42, 2.13) 1.11 (0.51, 2.43) 1.71 (0.84, 3.48) 0.129
Age-adjusted model 0.93 (0.41, 2.10) 1.07 (0.49, 2.35) 1.61 (0.78, 3.31) 0.180
Multivariate-adjusted modelb 1.16 (0.46, 2.89) 1.12 (0.47, 2.71) 1.65 (0.73, 3.74) 0.270
Multivariate-adjusted model + smoking status 1.24 (0.49, 3.18) 1.31 (0.52, 3.28) 1.85 (0.79, 4.36) 0.170
Multivariate-adjusted model + CVD risk factorsc 1.12 (0.44, 2.89) 1.03 (0.41, 2.59) 1.86 (0.79, 4.34) 0.204
IL-10 Crude model 1.30 (0.53, 3.14) 2.73 (1.23, 6.05) 1.89 (0.82, 4.34) 0.045
Age-adjusted model 1.27 (0.52, 3.11) 2.55 (1.14, 5.68) 1.63 (0.70, 3.79) 0.107
Multivariate-adjusted modelb 1.48 (0.56, 3.93) 2.02 (0.81, 5.04) 1.57 (0.62, 3.96) 0.263
Multivariate-adjusted model + smoking status 1.52 (0.56, 4.13) 2.13 (0.83, 5.44) 1.75 (0.68, 4.53) 0.184
Multivariate-adjusted model + CVD risk factorsc 1.74 (0.63, 4.81) 2.52 (0.96, 6.57) 1.89 (0.72, 4.95) 0.139
TNFα Crude model 2.33 (0.93, 5.83) 2.52 (1.02, 6.21) 3.24 (1.35, 7.79) 0.010
Age-adjusted model 2.43 (0.97, 6.13) 2.54 (1.02, 6.28) 3.09 (1.27, 7.47) 0.015
Multivariate-adjusted modelb 3.02 (0.99, 9.18) 3.69 (1.26, 10.78) 4.44 (1.54, 12.80) 0.005
Multivariate-adjusted model + smoking status 2.95 (0.96, 9.06) 3.40 (1.15, 10.08) 3.95 (1.35, 11.58) 0.012
Multivariate-adjusted model + CVD risk factorsc 3.37 (1.05, 10.83) 4.13 (1.35, 12.67) 5.34 (1.77, 16.16) 0.003
TNFαSRI Crude model 1.15 (0.47, 2.84) 1.54 (0.65, 3.64) 3.34 (1.53, 7.29) 0.002
Age-adjusted model 1.01 (0.41, 2.51) 1.25 (0.52, 2.99) 2.24 (0.97, 5.15) 0.051
Multivariate-adjusted modelb 1.24 (0.46, 3.34) 1.28 (0.48, 3.42) 2.26 (0.89, 5.75) 0.104
Multivariate-adjusted model + smoking status 1.16 (0.42, 3.16) 1.07 (0.39, 2.89) 1.80 (0.69, 4.69) 0.285
Multivariate-adjusted model + CVD risk factorsc 1.43 (0.50, 4.13) 1.59 (0.56, 4.52) 3.20 (1.15, 8.85) 0.029
TNFαSRII Crude model 1.83 (0.72, 4.68) 1.95 (0.77, 4.94) 3.74 (1.57, 8.88) 0.004
Age-adjusted model 1.64 (0.64, 4.21) 1.64 (0.64, 4.20) 2.65 (1.08, 6.54) 0.042
Multivariate-adjusted modela 1.79 (0.63, 5.06) 1.70 (0.60, 4.83) 2.50 (0.91, 6.85) 0.095
Multivariate-adjusted model + smoking status 1.50 (0.52, 4.33) 1.46 (0.50, 4.20) 2.11 (0.75, 5.91) 0.181
Multivariate-adjusted model + CVD risk factorsc 2.23 (0.72, 6.93) 2.66 (0.85, 8.32) 3.81 (1.25, 11.63) 0.019
CRP Crude model 1.78 (0.73, 4.32) 1.53 (0.61, 3.82) 3.37 (1.48, 7.64) 0.008
Age-adjusted model 1.92 (0.78, 4.71) 1.66 (0.66, 4.18) 3.43 (1.50, 7.85) 0.008
Multivariate-adjusted modelb 2.61 (0.95, 7.15) 1.88 (0.66, 5.36) 3.63 (1.41, 9.36) 0.020
Multivariate-adjusted model + smoking status 2.41 (0.87, 6.66) 1.52 (0.52, 4.44) 2.80 (1.06, 7.37) 0.092
Multivariate-adjusted model + CVD risk factorsc 2.02 (0.71, 5.73) 1.62 (0.56, 4.71) 3.24 (1.23, 8.55) 0.035
  1. aReference group = lowest quartile
  2. bMultivariate-adjusted models were adjusted for age, MI, hypertension, CHF, COPD, diabetes status, NSAID, Aspirin, cox-II inhibitor, ACE inhibitors, loop diuretics, antidepressants, self-rated health status, BMI, PASE score and walking speed
  3. cCVD risk factors included systolic blood pressure, fasting blood glucose, total cholesterol and HDL
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