Table 3 Association between cytokines and prevalent peripheral arterial disease (ABI <0.90)

IL-6

Crude model

1.94 (0.65, 5.87)

3.63 (1.31, 10.01)

6.00 (2.27, 15.91)

<0.001

Age-adjusted model

1.71 (0.57, 5.12)

3.13 (1.12, 8.71)

4.91 (1.83, 13.17)

0.001

Multivariate-adjusted model^b

1.37 (0.42, 4.46)

3.46 (1.19, 10.11)

3.95 (1.38, 11.26)

0.003

Multivariate-adjusted model + smoking status

1.32 (0.40, 4.31)

2.88 (0.98, 8.49)

2.90 (0.99, 8.52)

0.020

Multivariate-adjusted model + CVD risk factors^c

1.17 (0.34, 3.98)

3.39 (1.13,10.18)

3.57 (1.21, 10.50)

0.005

IL-6 SR

Crude model

0.95 (0.42, 2.13)

1.11 (0.51, 2.43)

1.71 (0.84, 3.48)

0.129

Age-adjusted model

0.93 (0.41, 2.10)

1.07 (0.49, 2.35)

1.61 (0.78, 3.31)

0.180

Multivariate-adjusted model^b

1.16 (0.46, 2.89)

1.12 (0.47, 2.71)

1.65 (0.73, 3.74)

0.270

Multivariate-adjusted model + smoking status

1.24 (0.49, 3.18)

1.31 (0.52, 3.28)

1.85 (0.79, 4.36)

0.170

Multivariate-adjusted model + CVD risk factors^c

1.12 (0.44, 2.89)

1.03 (0.41, 2.59)

1.86 (0.79, 4.34)

0.204

IL-10

Crude model

1.30 (0.53, 3.14)

2.73 (1.23, 6.05)

1.89 (0.82, 4.34)

0.045

Age-adjusted model

1.27 (0.52, 3.11)

2.55 (1.14, 5.68)

1.63 (0.70, 3.79)

0.107

Multivariate-adjusted model^b

1.48 (0.56, 3.93)

2.02 (0.81, 5.04)

1.57 (0.62, 3.96)

0.263

Multivariate-adjusted model + smoking status

1.52 (0.56, 4.13)

2.13 (0.83, 5.44)

1.75 (0.68, 4.53)

0.184

Multivariate-adjusted model + CVD risk factors^c

1.74 (0.63, 4.81)

2.52 (0.96, 6.57)

1.89 (0.72, 4.95)

0.139

TNFα

Crude model

2.33 (0.93, 5.83)

2.52 (1.02, 6.21)

3.24 (1.35, 7.79)

0.010

Age-adjusted model

2.43 (0.97, 6.13)

2.54 (1.02, 6.28)

3.09 (1.27, 7.47)

0.015

Multivariate-adjusted model^b

3.02 (0.99, 9.18)

3.69 (1.26, 10.78)

4.44 (1.54, 12.80)

0.005

Multivariate-adjusted model + smoking status

2.95 (0.96, 9.06)

3.40 (1.15, 10.08)

3.95 (1.35, 11.58)

0.012

Multivariate-adjusted model + CVD risk factors^c

3.37 (1.05, 10.83)

4.13 (1.35, 12.67)

5.34 (1.77, 16.16)

0.003

TNFαSRI

Crude model

1.15 (0.47, 2.84)

1.54 (0.65, 3.64)

3.34 (1.53, 7.29)

0.002

Age-adjusted model

1.01 (0.41, 2.51)

1.25 (0.52, 2.99)

2.24 (0.97, 5.15)

0.051

Multivariate-adjusted model^b

1.24 (0.46, 3.34)

1.28 (0.48, 3.42)

2.26 (0.89, 5.75)

0.104

Multivariate-adjusted model ₊ smoking status

1.16 (0.42, 3.16)

1.07 (0.39, 2.89)

1.80 (0.69, 4.69)

0.285

Multivariate-adjusted model + CVD risk factors^c

1.43 (0.50, 4.13)

1.59 (0.56, 4.52)

3.20 (1.15, 8.85)

0.029

TNFαSRII

Crude model

1.83 (0.72, 4.68)

1.95 (0.77, 4.94)

3.74 (1.57, 8.88)

0.004

Age-adjusted model

1.64 (0.64, 4.21)

1.64 (0.64, 4.20)

2.65 (1.08, 6.54)

0.042

Multivariate-adjusted model^a

1.79 (0.63, 5.06)

1.70 (0.60, 4.83)

2.50 (0.91, 6.85)

0.095

Multivariate-adjusted model ⁺ smoking status

1.50 (0.52, 4.33)

1.46 (0.50, 4.20)

2.11 (0.75, 5.91)

0.181

Multivariate-adjusted model + CVD risk factors^c

2.23 (0.72, 6.93)

2.66 (0.85, 8.32)

3.81 (1.25, 11.63)

0.019

CRP

Crude model

1.78 (0.73, 4.32)

1.53 (0.61, 3.82)

3.37 (1.48, 7.64)

0.008

Age-adjusted model

1.92 (0.78, 4.71)

1.66 (0.66, 4.18)

3.43 (1.50, 7.85)

0.008

Multivariate-adjusted model^b

2.61 (0.95, 7.15)

1.88 (0.66, 5.36)

3.63 (1.41, 9.36)

0.020

Multivariate-adjusted model + smoking status

2.41 (0.87, 6.66)

1.52 (0.52, 4.44)

2.80 (1.06, 7.37)

0.092

Multivariate-adjusted model + CVD risk factors^c

2.02 (0.71, 5.73)

1.62 (0.56, 4.71)

3.24 (1.23, 8.55)

0.035