Skip to main content

Table 2 Characteristics of men with and without peripheral arterial disease

From: Prevalent peripheral arterial disease and inflammatory burden

Characteristics Total N = 878 Men with PAD (ABI <0.90) N = 61 Men without PAD (ABI ≥0.90) N = 817 p-valuea
Cytokines
 IL-6 pg/ml, median (interquartile range) 2.40 (1.84) 3.38 (2.16) 2.34 (1.71) <0.001
 IL-6 SR pg/ml, median (interquartile range) 48636 (18103) 50655 (19051) 48494 (18064) 0.232
 IL-10 pg/ml, median (interquartile range) 8.98 (6.94) 10.62 (5.69) 8.87 (6.86) 0.012
 TNFα pg/ml, median (interquartile range) 3.95 (2.43) 4.55 (2.24) 3.91 (2.41) 0.032
 TNFαSRI pg/ml, median (interquartile range) 1918.50 (586.90) 2210.50 (853.10) 1900.70 (570.10) 0.002
 TNFαSRII pg/ml, median (interquartile range) 3499.80 (952.10) 3856.85 (1202.90) 3482.10 (922.70) 0.029
 CRP ug/ml, median (interquartile range) 1.40 (2.12) 2.24 (3.94) 1.37 (2.08) 0.042
 CRP >3 ug/mL, n (%) 209 (23.94) 24 (40.68) 185 (22.73) 0.002
Demographics
 Age, years, mean ± SD 73.71 ± 5.87 76.70 ± 5.99 73.48 ± 5.99 <0.001
 None-white race, n (%) 67 (7.63) 4 (6.56) 63 (7.71) 1.000
 High school or less, n (%) 217 (24.72) 19 (31.15) 198 (24.24) 0.227
Health status
 Self-rated health status, good/excellent, n (%) 753 (85.86) 44 (72.13) 709 (86.89) 0.001
 Body Mass Index (BMI), mean ± SD 27.32 ± 3.56 26.05 ± 3.25 27.42 ± 3.56 0.004
 Systolic blood pressure (mmHG), mean ± SD 139.09 ± 18.92 148.21 ± 24.13 138.41 ± 18.31 <0.001
 Fasting blood glucose (mg/dL), mean ± SD 106.68 ± 24.90 117.80 ± 41.47 105.83 ± 22.97 0.039
 Total cholesterol (mg/dL), mean ± SD 194.58 ± 32.84 191.44 ± 32.46 194.82 ± 32.87 0.442
 HDL (mg/dL), mean ± SD 48.96 ± 14.65 48.32 ± 15.85 49.01 ± 14.57 0.435
Medical conditions
 Myocardial infarction, n (%) 139 (15.83) 9 (14.75) 130 (15.91) 0.811
 Hypertension, n (%) 383 (43.62) 39 (63.93) 344 (42.11) 0.001
 Congestive heart failure, n (%) 36 (4.10) 7 (11.48) 29 (3.55) 0.003
 Chronic obstructive pulmonary disease, n (%) 97 (11.05) 8 (13.11) 89 (10.89) 0.593
Diabetes status     0.071
Diabetes, n (%) 142 (16.69) 16 (26.67) 126 (15.93)  
Pre-diabetes, n (%) 310 (36.43) 22 (36.67) 288 (36.41)  
Medication use
 NSAID, n (%) 130 (15.51) 10 (17.54) 120 (15.36) 0.661
 Aspirin, n (%) 284 (33.89) 20 (35.09) 264 (33.80) 0.843
 Cox-II inhibitor, n (%) 63 (7.52) 1 (1.75) 62 (7.94) 0.115
 ACE inhibitors, n (%) 166 (19.81) 18 (31.58) 148 (18.95) 0.021
 Loop diuretics, n (%) 38 (4.53) 8 (14.04) 30 (3.84) <0.001
 Antidepressants, n (%) 55 (6.65) 7 (12.28) 48 (6.23) 0.077
Physical performance
 Physical Activity Scale for the Elderly (PASE) score, mean ± SD 149.92 ± 69.95 130.25 ± 79.94 151.39 ± 68.98 0.008
 Walking speed <0.8 meters/seconds, n (%) 28 (3.19) 6 (9.84) 22 (2.69) 0.002
 Average number of drinks/week, mean ± SD 4.52 ± 6.90 4.77 ± 7.79 4.51 ± 6.84 0.275
Smoking status     <0.001
 Current smoker, n (%) 33 (3.76) 8 (13.11) 25 (3.06)  
 Past smoker, n (%) 514 (58.54) 40 (65.57) 474 (58.02)  
 Smoking pack-years, mean ± SD 18.97 ± 25.71 33.64 ± 32.44 17.87 ± 24.81 <0.001
  1. aBased on median test for cytokines variables, two-sample t test (or Wilcoxon-Mann–Whitney test) for other continuous variables and chi-squared test (or Fisher's exact test) for categorical variables
\