Table 2 The FRAGIRE pre-specified grid for dimension scores on day 0

General health status

Health status

Q1

Mean ± SD

< .0001

Missing

6

0

6

Health status compared to people of the same age group

Q2

Mean ± SD

5.7 ± 1.8

6.8 ± 2.0

5.5 ± 1.7

< .0001

Missing

21

3

18

More than 5 medication per day

Q3

No

165

42.97

27

57.45

138

40.95

Yes

218

56.77

20

42.55

198

58.75

Don’t know

1

0.26

0

1

0.30

.088

Missing

1

0

1

Number of hospitalizations within the last 6 months

Q4

0

275

72.37

36

76.60

239

71.77

1 - 2

93

24.47

9

19.15

84

25.23

More than 2

12

3.16

2

4.26

10

3.00

.619

Missing

5

5

Psychological

General well-being

Q5

Mean ± SD

< .0001

Missing

4

0

4

Spirit

Q6

Mean ± SD

< .0001

Missing

4

0

4

Unhappiness and depression

Q7

Not at all

160

41.67

23

48.94

137

40.65

A little

157

40.89

21

44.68

136

40.36

Quite a bit

49

12.76

2

4.26

47

13.95

Very much

18

4.69

1

2.13

17

5.04

.199

Missing

1

0

1

Happiness

Q8

Not at all

24

6.32

2

4.26

22

6.61

A little

109

28.68

6

12.77

103

30.93

Quite a bit

210

55.26

33

70.21

177

53.15

Very much

37

9.74

6

12.77

31

9.31

.036

Missing

5

5

Life satisfaction

Q9

Not very

160

41.99

24

51.06

136

40.72

Little

94

24.67

9

19.15

85

25.45

Pretty

102

26.77

13

27.66

89

26.65

Very much

25

6.56

1

2.13

24

7.19

.343

Missing

4

4

Discouragement and sadness

Q10

Not at all

105

27.63

20

42.55

85

25.53

A little

185

48.68

20

42.55

165

49.55

Quite a bit

65

17.11

6

12.77

59

17.72

Very much

25

6.58

1

2.13

24

7.21

.074

Missing

5

5

Positive consideration of life

Q11

Not at all

22

5.80

1

2.13

21

6.33

A little

132

34.83

12

25.53

120

36.14

Quite a bit

167

44.06

23

48.94

144

43.37

Very much

58

15.30

11

23.40

47

14.16

.160

Missing

6

6

Usefulness

Q12

Not at all

36

9.40

2

4.26

34

10.12

A little

72

18.80

11

23.40

61

18.15

Quite a bit

158

41.25

19

40.43

139

41.37

Very much

117

30.55

15

31.91

102

30.36

.541

Missing

2

2

Motivation to pursue leisure and usual activities

Q13

Not at all

62

16.23

4

8.51

58

17.31

A little

107

28.01

9

19.15

98

29.25

Quite a bit

144

37.70

21

44.68

123

36.72

Very much

69

18.06

13

27.66

56

16.72

.075

Missing

3

3

Tension, anger, stress

Q14

Not at all

87

22.66

9

19.15

78

23.15

A little

127

33.07

18

38.30

109

32.34

Quite a bit

113

29.43

17

36.17

96

28.49

Very much

57

14.84

3

6.38

54

16.02

.246

Missing

1

1

Difficulty sleeping

Q15

Not at all

128

33.51

23

48.94

105

31.34

A little

95

24.87

7

14.89

88

26.27

Quite a bit

88

23.04

10

21.28

78

23.28

Very much

71

18.59

7

14.89

64

19.10

.093

Missing

3

3

Tiredness

Q16

Not at all

50

13.05

14

29.79

36

10.71

A little

152

39.69

16

34.04

136

40.48

Quite a bit

113

29.50

13

27.66

100

29.76

Very much

68

17.75

4

8.51

64

19.05

.002

Missing

2

2

Enjoyment of daily activities

Q17

Not at all

30

7.83

4

8.51

26

7.74

A little

108

28.20

7

14.89

101

30.06

Quite a bit

177

46.21

23

48.94

154

45.83

Very much

68

17.75

13

27.66

55

16.37

.092

Missing

2

2

Positive view of life

Q18

Not at all

19

5.86

19

6.74

A little

117

36.11

9

21.43

108

38.30

Quite a bit

132

40.74

18

42.86

114

40.43

Very much

56

17.28

15

35.71

41

14.54

.002

Missing

61

5

56

Suicide ideation

Q19

Not at all

354

92.43

46

97.87

308

91.67

A little

26

6.79

1

2.13

25

7.44

Quite a bit

2

0.52

0

2

0.60

Very much

1

0.26

0

1

0.30

.479

Missing

2

0

2

Cognitive impairment

Difficulty concentrating

Q20

Not at all

229

59.48

35

74.47

194

57.40

A little

96

24.94

9

19.15

87

25.74

Quite a bit

47

12.21

1

2.13

46

13.61

Very much

13

3.38

2

4.26

11

3.25

.062

Missing

0

0

0

Difficulty remembering

Q21

Not at all

96

25.00

15

31.91

81

24.04

A little

204

53.13

28

59.57

176

52.23

Quite a bit

60

15.63

2

4.26

58

17.21

Very much

24

6.25

2

4.26

22

6.53

.102

Missing

1

1

Environmental

Caregivers support

Q22

No

46

12.57

8

17.78

38

11.84

Yes

320

87.43

37

82.22

283

88.16

.334

Don’t know

Missing

19

0

17

Satisfaction of support

Q23

Not at all

12

3.41

3

7.50

9

2.88

A little

21

5.97

3

7.50

18

5.77

Quite a bit

117

33.24

13

32.50

104

33.33

Very much

202

57.39

21

52.50

181

58.01

.372

Missing

33

7

26

Feeling of loneliness/abandonment

Q24

Not at all

215

56.58

35

74.47

180

54.05

A little

120

31.58

10

21.28

110

33.03

Quite a bit

34

8.95

1

2.13

33

9.91

Very much

11

2.89

1

2.13

10

3.00

.049

Missing

5

5

Contact with other impaired patients

Q25

Not at all

290

75.72

38

80.85

252

75.00

A little

60

15.67

5

10.64

55

16.37

Quite a bit

24

6.27

2

4.26

22

6.55

Very much

9

2.35

2

4.26

7

2.08

.478

Missing

2

2

Missing activities

Q26

No

189

49.48

25

53.19

164

48.96

Yes

193

50.52

22

46.81

171

51.04

.642

Don’t know

Missing

3

3

Envy of going out

Q27

No

98

25.72

12

25.53

86

25.75

Yes

278

72.97

35

74.47

243

72.75

Don’t know

5

1.31

0

5

1.50

1

Missing

4

4

Satisfaction with mode of transportation

Q28

No

39

10.18

2

4.26

37

11.01

Yes

341

89.03

45

95.74

296

88.10

Don’t know

3

0.78

0

3

0.89

.347

Missing

2

2

Financial problems

Q29

Not at all

219

57.48

34

72.34

185

55.39

A little

109

28.61

12

25.53

97

29.04

Quite a bit

30

7.87

0

30

8.98

Very much

23

6.04

1

2.13

22

6.59

.037

Missing

4

4

Sufficient financial resources

Q30

Not at all

102

26.91

5

10.64

97

29.22

A little

134

35.36

13

27.66

121

36.45

Quite a bit

139

36.68

28

59.57

111

33.43

Very much

4

1.06

1

2.13

3

0.90

.001

Missing

6

6

Cultural

Use of internet

Q31

Not at all

350

91.62

39

82.98

311

92.84

A little

16

4.19

0

16

4.78

Quite a bit

6

1.57

2

4.26

4

1.19

Very much

10

2.62

6

12.77

4

1.19

.0002

Missing

3

3

Participation in activities

Q32

Not at all

266

69.82

33

70.21

233

69.76

A little

57

14.96

5

10.64

52

15.57

Quite a bit

56

14.70

9

19.15

47

14.07

Very much

2

0.52

0

2

0.60

.634

Missing

4

4

Sexual

Troubled by signs of weakening

Q33

Not at all

58

15.18

14

29.79

44

13.13

A little

153

40.05

20

42.55

133

39.70

Quite a bit

115

30.10

6

12.77

109

32.54

Very much

56

14.66

7

14.89

49

14.63

.005

Missing

3

3

Troubled by signs of aging

Q34

Not at all

128

33.60

19

40.43

109

32.63

A little

136

35.70

18

38.30

118

35.33

Quite a bit

88

23.10

8

17.02

80

23.95

Very much

29

7.61

2

4.26

27

8.08

.476

Missing

4

4

Positive self-image

Q35

Not at all

39

10.40

5

10.64

34

10.37

A little

140

37.33

13

27.66

127

38.72

Quite a bit

165

44.00

24

51.06

141

42.99

Very much

31

8.27

5

10.64

26

7.93

.459

Missing

10

10

Interest in sexual activity

Q36

Not at all

326

86.70

36

78.26

290

87.88

A little

39

10.37

9

19.57

30

9.09

Quite a bit

9

2.39

1

2.17

8

2.42

Very much

2

0.53

0

2

0.61

.149

Missing

9

8

Burden of help

Helping other relatives

Q37

Not at all

257

67.10

24

51.06

233

69.35

A little

49

12.79

11

23.40

38

11.31

Quite a bit

31

8.09

4

8.51

27

8.04

Very much

46

12.01

8

17.02

38

11.31

.048

Missing

2

2

Responsible of other relatives

Q38

Not at all

131

53.47

11

35.48

120

56.07

A little

26

10.61

4

12.90

22

10.28

Quite a bit

38

15.51

10

32.26

28

13.08

Very much

50

20.41

6

19.35

44

20.56

.037

Missing

140

16

124

Difficulty with self-care

Q39

Not at all

105

33.23

15

40.54

90

32.26

A little

36

11.39

9

24.32

27

9.68

Quite a bit

23

7.28

2

5.41

21

7.53

Very much

13

4.11

1

2.70

12

4.30

Don’t concern

139

43.99

10

27.03

129

46.24

.046

Missing

69

10

59

Nutritional

Problems with taste

Q40

Not at all

336

87.73

42

89.36

294

87.50

A little

28

7.31

3

6.38

25

7.44

Quite a bit

10

2.61

0

10

2.98

Very much

9

2.35

2

4.26

7

2.08

.534

Missing

2

2

Lack of appetite

Q41

Not at all

253

66.23

33

71.74

220

65.48

A little

81

21.20

9

19.57

72

21.43

Quite a bit

31

8.12

3

6.52

28

8.33

Very much

17

4.45

1

2.17

16

4.76

.901

Missing

3

1

2

Reduced food intake

Q42

Not at all

221

58.01

25

54.35

196

58.51

A little

110

28.87

14

30.43

96

28.66

Quite a bit

36

9.45

5

10.87

31

9.25

Very much

14

3.67

2

4.35

12

3.58

.862

Missing

4

1

3

Weight loss

Q43

Not at all

258

67.36

38

80.85

220

65.48

A little

80

20.89

4

8.51

76

22.62

Quite a bit

24

6.27

4

8.51

20

5.95

Very much

21

5.48

1

2.13

20

5.95

.058

Missing

2

2

Number of dental consultations

Q44

0

230

60.05

18

38.30

212

63.10

1

99

25.85

21

44.68

78

23.21

More than 1

53

13.84

8

17.02

45

13.39

Don’t know

1

0.26

0

1

0.30

.005

Missing

2

2

Frequent dental pain

Q45

No

334

87.43

41

87.23

293

87.46

Yes

48

12.57

6

12.77

42

12.54

1

Missing

3

3

Capable to eat on its own

Q46

No

11

2.88

2

4.26

9

2.69

Yes

371

97.12

45

95.74

326

97.31

.632

Missing

3

3

Denture

Q47

No

105

27.49

17

36.17

88

26.27

Yes

277

72.51

30

63.83

247

73.73

.165

Missing

3

3

Neurosensory

Deterioration in vision

Q48

Not at all

133

34.73

21

44.68

112

33.33

A little

126

32.90

12

25.53

114

33.93

Quite a bit

68

17.75

10

21.28

58

17.26

Very much

56

14.62

4

8.51

52

15.48

.245

Missing

2

2

Need of glasses

Q49

No

310

81.15

36

76.60

274

81.79

Yes

72

18.85

11

23.40

61

18.21

.426

Don't known

Missing

3

3

Hearing discomfort

Q50

Not at all

183

47.78

24

51.06

159

47.32

A little

110

28.72

13

27.66

97

28.87

Quite a bit

54

14.10

6

12.77

48

14.29

Very much

36

9.40

4

8.51

32

9.52

.984

Missing

2

2

Hearing aid

Q51

No

332

87.14

38

82.61

294

87.76

Yes

49

12.86

8

17.39

41

12.24

.347

Missing

4

1

3

Suitable hearing aid

Q52

No

15

25.42

3

30.00

12

24.49

Yes

38

64.41

7

70.00

31

63.27

Don’t know

6

10.17

0

6

12.24

.753

Missing

326

37

289

Hearing impairment

Q53

No

218

62.11

29

65.91

189

61.56

Yes

128

36.47

15

34.09

113

36.81

Don’t know

5

1.42

0

5

1.63

.867

Missing

34

3

31

Mobility

Falls

Q54

0

261

68.32

38

80.85

223

66.57

1

69

18.06

4

8.51

65

19.40

More than 1

52

13.61

5

10.64

47

14.03

.117

Don’t know

0

0

Missing

3

3

Physical difficulties

Q55

Not at all

43

11.32

10

21.28

33

9.91

A little

71

18.68

11

23.40

60

18.02

Quite a bit

110

28.95

15

31.91

95

28.53

Very much

156

41.05

11

23.40

145

43.54

.023

Missing

5

5

Walking speed

Q56

> =1m/s

126

34.24

22

47.83

104

32.30

Between 0.65 and < 1m/s

112

30.43

16

34.78

96

29.81

<0.65m/s

130

35.33

8

17.39

122

37.89

.019

Missing

17

1

16

Going to toilet on its own

Q57

No

36

9.45

36

10.75

Yes

345

90.55

46

299

89.25

.013

Missing

4

1

3

Need help going to toilet

Q58

No

74

66.67

15

93.75

59

62.11

Yes

37

33.33

1

6.25

36

37.89

.019

Missing

274

31

243

Difficulties shopping on its own

Q59

No

125

32.98

28

60.87

97

29.13

Yes

254

67.02

18

39.13

236

70.87

< .0001

Don’t know

Missing

6

1

5

Need help shopping

Q60

No

46

16.25

13

44.83

33

12.99

Yes

237

83.75

16

55.17

221

87.01

< .0001

Missing

102

18

84

Doing cleaning on its own

Q61

No

311

81.84

16

34.78

295

88.32

Yes

69

18.16

30

65.22

39

11.68

< .0001

Don't know

Missing

5

1

4

Need help cleaning

Q62

No

23

6.73

11

40.74

12

3.81

Yes

319

93.27

16

59.26

303

96.19

< .0001

Missing

43

20

23

Section for examiner

Global health status

Q63

Mean ± SD

< .0001

Missing

4

0

4

Health status compared to people of the same age group

Q64

Mean ± SD

< .0001

Missing

4

0

4

Risk of deterioration

Q65

Mean ± SD

.025

Missing

5

0

5