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Table 3 Baseline characteristics and outcome 12 months after acute hospitalization in patients with different anemia subtypes

From: Readmission and mortality one year after acute hospitalization in older patients with explained and unexplained anemia - a prospective observational cohort study

 

No anemia

Explained anemia subtypes, n=275

  

Renal anemiaa

Iron deficienyb

B12/folate deficiencyc

Multifactoriald

 

N=474

N=139

N=55

N=12

N=69

 Age

84 (6.0)

86 (6.3)

85 (6.0)

83 (7.5)

84 (6.0)

 Male sex

119 (25 %)

52 (37 %)**

19 (35 %)

8 (67 %)**

35 (51 %)**

 Barthel index

80 (60–90)

75 (60–85)

65 (55–83)**

75 (70–80)

80 (55–90)

Diagnosis

 hip fracture

15 (3 %)

10 (7 %)

5 (9 %)

3 (25 %)

3 (4 %)

 other orthopaedic trauma

144 (30 %)

39 (28 %)

20 (36 %)

2 (17 %)

10 (15 %)

 acute infection

116 (25 %)

37 (27 %)

12 (22 %)

2 (17 %)

20 (29 %)

 heart disease

68 (14 %)

24 (18 %)

8 (16 %)

3 (20 %)

15 (22 %)

 other medical diseases

131 (28 %)

29 (21 %)

10 (19 %)

3 (20 %)

21 (30 %)

Laboratory parameters

 Hb, g/dL

13.6 (1.1)

11.0 (0.9)**

10.8 (0.8)**

11.5 (0.9)**

11.0 (1.1)**

 MCV, fL

94 (5.2)

94 (5.3)

91 (7.0)**

94 (7.5)

95 (5.2)*

 Vitamin B12, pmol/L

471 (331–780)

601 (403–841)**

581 (393–765)

282 (177–1009)

541 (328–775)

 Folat, nmol/L

16 (11–24)

17 (12–27)

19 (13–29)

7 (6–11)**

13 (8–19)

 Ferritin, μg/L

179 (101–333)

228 (119–400)*

120 (45–201)**

252 (175–424)

168 (74–294)

 Transferrin receptor, ml/L

3.3 (2.7–4.2)

3.1 (2.5–3.6)*

5.7 (4.8–6.9)**

3.2 (3.0–3.7)

5.2 (4.5–6.9)**

 CRP, mg/L

13 (5–30)

22 (9–48)**

26 (14–57)**

31 (22–78)**

27 (12–64)**

 NTpro-BnP

70 (28–188)

294 (104–636)**

110 (50–263)*

86 (33–200)

290 (55–963)**

12 months follow up

  > 2 hospital admissions

124 (26 %)

36 (39 %)

21 (50 %)**

2 (18 %)

23 (41 %)*

 Dead

74 (16 %)

25 (21 %)

12 (23 %)

2 (18 %)

16 (23 %)

  1. aanemia + estimated GFR (described in methods) < 60 mL/min/1.73 m2
  2. banemia + ferritin < 35 ug/L or transferrin receptor > 4.5 mg/L
  3. canemia + Vit B12 < 200 pmol/L or folate <8 nmol/L
  4. drenal anemia and iron deficiency anemia (n=40), renal anemia + B12/folater deficiency anemia (n=11) or renal anemia + iron deficiency anemia + B12/folate deficiency anemia (n=6)
  5. Continous parameters are presented as mean (standard deviation) or median (interquartile range), categorical data are presented as numbers (percentages)
  6. Hb haemoglobin, MCV mean corpuscular volume, CRP C-reactive protein, NT pro- BnP N-Terminal pro brain-type natriuretic peptide, *p < 0.05, **p < 0.01 when patients with each of the anemia subtypes were compared to patients without anemia