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Table 4 Collapsed rare variant analysis of candidate genes associated with HAI. These genes were found to have a p-value <1.0x10−3 by at least one burden-testing algorithm

From: Candidate gene resequencing to identify rare, pedigree-specific variants influencing healthy aging phenotypes in the long life family study

Phenotype

Gene

RefSeq

Total Exons

Analyzed Exons

Indiv Seq (#)

Variants called (#)

Ped (#)

P-value (PWST)

P-value (Skat)

Healthy Aging Index (Mortality Weighted)

GSK3B

NM_002093

12

8

3217

77

121

1.00E-4

2.08E-4

Diastolic Blood Pressure

NOTCH1

NM_017617

34

3

4112

55

78

1.00E-4

5.37E-3

HDL Cholesterol

TP53

NM_000546

11

6

4073

21

86

1.00E-4

8.05E-3