From: The Klotho gene G-395A polymorphism and metabolic syndrome in very elderly people
Characteristics | Total (N = 695) | Men (N = 220) | Women (N = 475) | ||||||
---|---|---|---|---|---|---|---|---|---|
MetS (N = 65) | Non-MetS (N = 630) | P | MetS (N = 7) | Non-MetS (N = 213) | P | MetS (N = 58) | Non-MetS (N = 417) | P | |
Age (years) | 93.3 ± 3.0 | 93.6 ± 3.2 | 0.532 | 92.7 ± 2.8 | 93.3 ± 3.1 | 0.606 | 93.4 ± 3.1 | 93.7 ± 3.3 | 0.505 |
Women (%) | 89.2 | 66.2 | <0.001 | - | - | - | - | - | - |
BMI (kg/m2) | 22.3 ± 3.3 | 18.9 ± 3.6 | <0.001 | 23.8 ± 4.5 | 19.6 ± 3.8 | 0.004 | 22.2 ± 3.1 | 18.6 ± 3.4 | <0.001 |
WC (cm) | 87.8 ± 5.2 | 76.5 ± 7.9 | <0.001 | 92.1 ± 2.5 | 78.3 ± 7.3 | <0.001 | 87.2 ± 5.2 | 75.6 ± 8.1 | <0.001 |
SBP (mm Hg) | 156 ± 18.2 | 138 ± 23.3 | <0.001 | 152.9 ± 11.1 | 137.6 ± 20.3 | 0.049 | 156.8 ± 18.9 | 139.3 ± 24.7 | <0.001 |
DBP (mm Hg) | 78.4 ± 15.1 | 72.0 ± 11.6 | <0.001 | 77.1 ± 7.6 | 73.1 ± 11.2 | 0.345 | 78.5 ± 15.8 | 71.4 ± 11.7 | 0.001 |
FPG (mmol/L) | 5.1 ± 2.1 | 4.4 ± 1.3 | <0.001 | 7.4 ± 2.8 | 4.5 ± 1.5 | <0.001 | 4.9 ± 1.8 | 4.3 ± 1.2 | 0.022 |
TC (mom/L) | 4.5 ± 1.0 | 4.6 ± 2.0 | 0.930 | 4.1 ± 1.1 | 5.3 ± 2.6 | 0.874 | 4.5 ± 1.0 | 4.2 ± 0.8 | <0.001 |
TG (mmol/L) | 2.0 ± 1.1 | 1.2 ± 0.6 | <0.001 | 1.9 ± 1.0 | 1.0 ± 0.4 | <0.001 | 2.1 ± 1.2 | 1.2 ± 0.6 | <0.001 |
LDL-C (mmol/L) | 2.6 ± 0.7 | 2.2 ± 0.6 | <0.001 | 2.5 ± 0.7 | 2.1 ± 0.5 | 0.079 | 2.6 ± 0.7 | 2.3 ± 0.6 | <0.001 |
HDL-C (mmol/L) | 1.4 ± 0.5 | 1.6 ± 0.8 | 0.020 | 1.2 ± 0.3 | 1.5 ± 0.7 | 0.179 | 1.4 ± 0.5 | 1.7 ± 0.8 | 0.019 |
SUA (mmol/L) | 342.4 ± 83.4 | 316.3 ± 88.3 | 0.023 | 394.7 ± 31.4 | 350.9 ± 87.6 | 0.189 | 336.0 ± 85.6 | 298.6 ± 83.4 | 0.002 |
Smoking habits* (%) | 35.9 | 43.6 | 0.237 | 85.7 | 69.7 | 0.361 | 29.8 | 30.4 | 0.934 |
Alcohol habits** (%) | 14.1 | 27.2 | 0.022 | 28.6 | 39.0 | 0.576 | 12.3 | 21.3 | 0.113 |
Exercise habits*** (%) | 36.9 | 41.0 | 0.524 | 14.3 | 42.3 | 0.139 | 39.7 | 40.3 | 0.920 |
Klotho G-395A Genotypes | |||||||||
GG (%) | 81.5 | 69.2 | 0.046 | 85.7 | 72.8 | 0.447 | 81.0 | 67.4 | 0.034 |
GA (%) | 18.5 | 28.9 | 14.3 | 27.2 | 19.0 | 29.7 | |||
AA (%) | 0 | 1.9 | 0 | 0 | 0 | 2.9 |