Who benefits from orthogeriatric treatment? Results from the Trondheim hip-fracture trial

Prestmo, Anders; Saltvedt, Ingvild; Helbostad, Jorunn L.; Taraldsen, Kristin; Thingstad, Pernille; Lydersen, Stian; Sletvold, Olav

doi:10.1186/s12877-016-0218-1

BMC Geriatrics

Table 2 Results of linear mixed model analysis

From: Who benefits from orthogeriatric treatment? Results from the Trondheim hip-fracture trial

	CGC	OC			CGC	OC			2-way interaction
	(mean)	(mean)	GD (95 % CI)	p-value	(mean)	(mean)	GD (95 % CI)	p-value	GD (95 % CI)	p-value
					4 months (n = 325)
		Age 70–79 (n = 98)			Age 80 or older (n = 227)
SPPB	6.41	5.32	1.09 (0.19–1.99)	0.017	4.53	3.91	0.62 (0.03–1.20)	0.039	0.47 (−0.60 to 1.55)	0.39
Barthel	17.19	15.27	1.92 (0.66–3.18)	0.003	16.05	15.49	0.56 (−0.26–1.37)	0.18	1.36 (−0.14 to 2.86)	0.08
NEAS	39.18	27.73	11.44 (6.54–16.35)	<0.0001	30.30	27.36	2.94 (−0.25 to 6.13)	0.07	8.50 (2.65–14.35)	0.004
MMSE	25.64	23.66	1.97 (−0.06–4.02)	0.06	23.02	22.33	0.70 (−0.62–2.02)	0.30	1.28 (−1.14–3.71)	0.30
		Male (n = 78)			Female (n = 247)
SPPB	5.09	5.03	0.06 (−0.93–1.05)	0.91	5.07	4.14	0.94 (0.37–1.50)	0.001	0.88 (−0.26–2.02)	0.13
Barthel	15.94	15.60	0.34 (−1.03–1.72)	0.63	16.51	15.36	1.15 (0.36–1.94)	0.005	0.81 (−0.78–2.40)	0.32
NEAS	30.43	27.13	3.30 (−2.08–8.68)	0.23	33.60	27.58	6.02 (2.93–9.12)	0.0001	2.72 (−3.48–8.93)	0.39
MMSE	23.75	22.64	1.11 (−1.13–3.34)	0.33	23.79	22.78	1.01 (−0.27–2.29)	0.12	0.09 (−2.48–2.67)	0.94
		Intra-capsular fracture (n = 203)			Extra-Capsular fracture (n = 122)
SPPB	5.61	4.54	1.07 (0.46–1.69)	0.001	4.21	4.07	0.14 (−0.66–0.94)	0.73	0.93 (−0.08–1.95)	0.07
Barthel	17.00	15.47	1.53 (0.66–2.39)	0.001	15.40	15.38	0.02 (−1.10–1.14)	0.97	1.51 (0.09–2.92)	0.037
NEAS	35.02	28.16	6.85 (3.48–10.23)	0.0001	29.35	26.40	2.94 (−1.45–7.34)	0.19	3.91 (−1.64–9.45)	0.17
MMSE	24.01	22.62	1.39 (−0.01–2.80)	0.05	23.47	22.97	0.50 (−1.30–2.30)	0.59	0.90 (−1.39–3.19)	0.44
		Pre-fracture NEAS ≥ 45 (n = 178)			Pre-fracture NEAS < 45 (n = 147)
SPPB	6.59	5.66	0.93 (0.28–1.59)	0.005	3.22	2.78	0.45 (−0.26–1.15)	0.22	0.49 (0.48–1.45)	0.32
Barthel	18.36	17.83	0.53 (−0.40–1.47)	0.27	14.06	12.64	1.42 (0.42–2.42)	0.005	0.89 (−0.48–2.26)	0.20
NEAS	44.77	37.44	7.34 (3.83–10.84)	<0.0001	19.06	16.03	3.03 (−0.73–6.78)	0.11	4.31 (−0.82–9.45)	0.10
MMSE	26.44	25.01	1.43 (−0.08–2.94)	0.06	20.51	19.88	0.62 (−1.01–2.25)	0.45	0.80 (−1.42–3.03)	0.48
					12 months (n = 284)
		Age 70–79 (n = 87)			Age 80 or older (n = 197)
SPPB	6.48	5.64	0.84 (−0.09–1.78)	0.08	4.63	3.93	0.70 (0.08–1.31)	0.027	0.14 (−0.98–1.26)	0.80
Barthel	17.34	16.29	1.05 (−0.24–2.35)	0.11	16.20	15.09	1.11 (0.26–1.95)	0.011	0.05 (−1.49–1.60)	0.95
NEAS	39.01	31.33	7.68 (2.62–12.64)	0.003	31.75	26.63	5.12 (1.79–8.45)	0.003	2.56 (−3.50–8.62)	0.41
MMSE	25.13	22.90	2.23 (0.16–4.30)	0.035	23.00	21.92	1.07 (−0.27–2.42)	0.12	1.16 (−1.31–3.63)	0.36
		Male (n = 65)			Female (n = 219)
SPPB	5.33	5.47	−0.14 (−1.20–0.91)	0.79	5.13	4.17	0.96 (0.37–1.55)	0.001	1.10 (−0.11–2.31)	0.07
Barthel	16.25	15.78	0.47 (−0.99–1.93)	0.53	16.62	15.38	1.24 (0.42–2.06)	0.003	0.77 (−0.90–2.44)	0.37
NEAS	33.07	27.78	5.29 (−0.47–11.04)	0.07	34.10	28.21	5.89 (2.69–9.08)	0.0003	0.60 (−5.98–7.19)	0.86
MMSE	23.95	21.36	2.59 (0.30–4.87)	0.027	23.50	22.49	1.01 (−0.29–2.31)	0.13	1.58 (−1.05–4.01)	0.24
		Intra-capsular fracture (n = 177)			Extra-Capsular fracture (n = 107)
SPPB	5.61	4.42	1.19 (0.54–1.84)	0.0003	4.45	4.51	−0.06 (−0.090–0.78)	0.89	1.25 (0.19–2.31)	0.021
Barthel	16.95	15.33	1.62 (0.72–2.52)	0.0004	15.85	15.72	0.13 (−1.02–1.27)	0.83	1.49 (0.04–2.95)	0.045
NEAS	35.15	28.76	6.40 (2.86–9.83)	0.0004	31.66	27.05	4.61 (0.11–9.11)	0.045	1.79 (−3.94–7.51)	0.54
MMSE	22.94	22.37	1.14 (−0.29–2.58)	0.12	23.77	22.00	1.77 (−0.06–3.61)	0.06	0.63 (−1.70–2.96)	0.60
		Pre-fracture NEAS ≥ 45 (n = 164)			Pre-fracture NEAS < 45 (n = 120)
SPPB	6.81	5.98	0.83 (0.16–1.51)	0.016	3.06	2.57	0.49 (−0.26–1.24)	0.20	0.34 (−0.67–1.35)	0.51
Barthel	18.74	17.68	1.05 (0.10–2.01)	0.031	13.89	12.88	1.01 (−0.04–2.06)	0.06	0.05 (−1.37–1.47)	0.95
NEAS	47.11	38.38	8.73 (5.14–12.32)	<0.0001	18.08	16.18	1.90 (−2.06–5.85)	0.35	6.83 (1.48–12.17)	0.012
MMSE	26.33	24.42	1.91 (0.38–3.44)	0.015	20.24	19.47	0.77 (−0.91–2.45)	0.37	1.14 (−1.14–3.41)	0.33

The two-way interaction term GD is the difference in effect of CGC vs OC between the subgroups, for example 1.09–0.62 = 0.47 for SPPB, age70-79 vs age 80+, 4 months
CGC Comprehensive Geriatric Care, OC orthopaedic care, GD Group difference, SPPB Short Physical Performance Battery, Barthel Barthel Index, NEAS Nottingham Extended ADL Scale, MMSE Mini Mental Status Examination

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