Interactive effects of diabetes and impaired kidney function on cognitive performance in old age: a population-based study

Table 2 Association of diabetes and eGFR_cys with the Mini-Mental State Examination (MMSE) score and cognitive impairment

	β coefficient (95 % CI) of MMSE score^a		Odds ratio (95 % CI) of cognitive impairment
Factors	Model 1^b	Model 2^b	Model 1^b	Model 2^b
Diabetes	−0.09 (−0.18,−0.0004)	−0.06 (−0.16, 0.03)	1.81 (1.27, 2.60)	1.75 (1.20, 2.53)
eGFR_cys, ml/min/1.73 m²
≥90	0 (reference)	0 (reference)	1.00 (reference)	1.00 (reference)
60–89.9	−0.004 (−0.10, 0.09)	−0.01 (−0.10, 0.08)	0.99 (0.64, 1.52)	0.98 (0.63, 1.52)
<60	−0.15 (−0.28, −0.02)	−0.15 (−0.28, −0.02)	1.32 (0.78, 2.22)	1.37 (0.80, 2.35)
p _trend	0.039	0.046	0.27	0.23

CI confidence interval, eGFR _cys cystatin C-based estimated glomerular filtration rate, MMSE Mini-Mental State Examination
^aThe original MMSE score was transformed as –log (31-MMSE score)
^bModel 1 was adjusted for age, sex, and years of education, and model 2 was further adjusted for smoking, physical activity, alcohol drinking, body mass index, total cholesterol, hypertension, stroke, and depressive symptoms

ISSN: 1471-2318