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Table 6 Associations between adiposity measures, sarcopenia and cognitive function after adjustments for sociodemographic characteristics, lifestyle factors and inflammatory or metabolic markers in a study of British men aged 71–92 years in 2010-12

From: The relationships between body composition characteristics and cognitive functioning in a population-based sample of older British men

 

Mild cognitive impairment (n = 636, 41 %)

Severe cognitive impairment (n = 133, 8 %)

 

RR (95 % CI)a

RR (95 % CI)b

RR (95 % CI)c

RR (95 % CI) a

RR (95 % CI) b

RR (95 % CI)c

Waist Circumference (>102 cm)

1.14 (0.88–1.46)

1.25 (0.95–1.66)

1.15 (0.88–1.49)

1.63 (1.05–2.55)§

1.55 (0.94–2.55)

1.52 (0.95–2.43)

BMI (>30 kg/m2)

1.18 (0.86–1.62)

1.22 (0.85–1.75)

1.16 (0.83–1.62)

2.25 (1.36–3.72)ǁ

2.09 (1.17–3.72)§

2.30 (1.36–3.91)ǁ

MAMC Bottom Quintile (<=22.09 cm)

0.91 (0.67–1.23)

0.87 (0.63–1.20)

0.87 (0.64–1.19)

0.76 (0.42–1.36)

0.69 (0.37–1.31)

0.76 (0.42–1.40)

Central Fat Mass Top Quintile (> = 6.3 kg/m2)

0.99 (0.71–1.37)

1.20 (0.83–1.74)

1.06 (0.75–1.49)

1.85 (1.09–3.14)§

1.36 (0.72–2.59)

1.65 (0.93–2.91)

Peripheral Fat Mass Top Quintile (> = 3.4 kg/m2)

1.00 (0.72–1.40)

1.16 (0.80–1.69)

1.06 (0.75–1.50)

2.67 (1.59–4.48)ǁ

2.25 (1.23–4.13)ǁ

2.57 (1.48–4.45)ǁ

Visceral Fat Level Top Quintile (> = 6.9/m2)

1.33 (0.94–1.88)

1.54 (1.05–2.28)§

1.35 (0.94–1.95)

2.28 (1.32–3.94)ǁ

1.99 (1.05–3.78)§

2.27 (1.27–4.06)ǁ

Total Fat Mass Upper Quintile (> = 9.7 kg/m2)

1.04 (0.75–1.44)

1.28 (0.88–1.85)

1.13 (0.80–1.59)

2.16 (1.29–3.63)ǁ

1.70 (0.92–3.15)

2.01 (1.16–3.49)§

Sarcopenia (Severe) - EWGSOP definition

1.31 (0.53–3.22)

1.41 (0.56–3.54)

1.40 (0.56–3.51)

2.79 (0.89–8.74)

2.67 (0.78–9.20)

2.84 (0.89–9.09)

Sarcopenia - FNIH definition

1.41 (0.58–3.39)

1.81 (0.71–4.64)

1.72 (0.67–4.40)

1.30 (0.32–5.18)

1.64 (0.39–6.91)

1.47 (0.35–6.12)

  1. Reference is the normal cognitive ageing group
  2. RR Relative risk ratios, MAMC Mid-arm muscle circumference, BMI Body-Mass Index, CVD Cardiovascular Disease, IR Insulin-resistance, IL-6 Interleukin-6, FNIH Foundation for the National Institutes of Health, EWGSOP European Working Group on Sarcopenia in Older People
  3. § p < .05
  4. ǁ p < .01
  5. a Models adjusted for age, alcohol consumption, smoking, social class, physical activity, history of CVD, and history of diabetes
  6. b Models adjusted for age, alcohol consumption, smoking, social class, physical activity, history of CVD, history of diabetes and IR
  7. c Models adjusted for age, alcohol consumption, smoking, social class, physical activity, history of CVD, history of diabetes and IL-6