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Table 3 Comparison of number of hip fractures (n) during exposed and unexposed person-timea (SIR, 95 % CI)

From: Risk of hip fracture among older people using antihypertensive drugs: a nationwide cohort study

 

Total cohort

By sex

By birth cohort

Attributable effect (%)

Exposed person-days (DDD)

  

Women

Men

1935–1944

1925–1934

1915–1924

<1915

 
 

n

SIR (CI)

n

SIR (CI)

n

SIR (CI)

n

SIR (C)I)

n

SIR (CI)

n

SIR (CI)

n

SIR (CI)

 

Thiazide

550

0.7 (0.6–0.7)

441

0.7 (0.6–0.8)

109

0.6 (0.5–0.8)

61

0.7 (0.5–0.8)

208

0.6 (0.6–0.7)

258

0.7 (0.6–0.8)

23

0.8 (0.5–1.2)

–0.6

Loop diuretic

4752

1.0 (1.0–1.0)

3422

1.0 (0.9–1.0)

1330

1.1 (1.1–1.2)

371

2.0 (1.8–2.3)

1538

1.3 (1.2–1.3)

2543

0.9 (0.8–0.9)

300

0.7 (0.6–0.8)

0.1

Beta blocker

4074

0.7 (0.7–0.8)

3010

0.8 (0.8–0.8)

1064

0.7 (0.6–0.7)

511

0.9 (0.9–1.0)

1700

0.8 (0.8–0.8)

1757

0.7 (0.6–0.7)

106

0.6 (0.5–0.8)

–3.5

Calcium channel blocker

5028

0.8 (0.8–0.8)

3736

0.8 (0.8–0.8)

1292

0.7 (0.7–0.8)

642

1.0 (0.9–1.1)

1982

0.8 (0.8–0.8)

2234

0.7 (0.7–0.8)

170

0.7 (0.6–0.8)

–3.4

ACE inhibitor

3438

0.9 (0.9–1.0)

2351

1.0 (0.9–1.0)

1087

0.9 (0.8–0.9)

410

1.3 (1.1–1.4)

1389

1.1 (1.0–1.1)

1512

0.8 (0.8–0.8)

127

0.7 (0.6–0.9)

–0.6

ACE inhibitor/Thiazide

662

0.7 (0.6–0.7)

520

0.7 (0.6–0.8)

142

0.5 (0.4–0.6)

111

1.9 (0.8–1.2)

264

0.7 (0.6–0.7)

261

0.6 (0.5–0.6)

26

0.9 (0.6–1.3)

–0.9

Angiotensin II receptor blocker

2631

0.8 (0.7–0.8)

2041

0.8 (0.8–0.8)

590

0.7 (0.6–0.7)

411

0.9 (0.8–1.0)

1049

0.7 (0.7–0.8)

1094

0.8 (0.7–0.8)

77

0.8 (0.6–1.0)

–1.9

Angiotensin II receptor blocker/Thiazide

2122

0.6 (0.6–0.6)

1688

0.6 (0.6–0.7)

434

0.5 (0.4–0.5)

367

0.7 (0.6–0.7)

915

0.6 (0.6–0.6)

790

0.6 (0.5–0.6)

50

0.6 (0.5–0.9)

–3.6

  1. SIR Standardized Incidence Ratio, DDD Defined Daily Dose, Attributable effect percentage of hip fractures during DDD exposure throughout the study period
  2. aThe population of Norway born before 1945 and exposed to various antihypertensive drugs in 2005–2010 (exposed person-days, DDD)