Relationship between biomarkers of inflammation, oxidative stress and endothelial/microcirculatory function in successful aging versus healthy youth: a transversal study

Table 1 Subjects clinical and laboratorial data

	Young Controls (n = 24)	Healthy Elderly (n = 11)	p value
Age	23.1 ± 3.6	74.0 ± 8.7*	<0.001
Body mass index (kg/m²)	21.7 ± 2.1	24.5 ± 3.9*	0.002
Waist to hip ratio	0.73 ± 0.04	0.83 ± 0.06*	<0.001
Systolic BP, mmHg	108 ± 11	128 ± 17*	0.01
Diastolic BP, mmHg	69 ± 8	69 ± 11	0.738
Heart Rate , bpm	65 ± 8	70 ± 10	0.650
Fasting glucose, mg/dl	81 ± 8	89 ± 4*	<0.001
Fasting insulin, μUI/ml	7 ± 3	6 ± 3	0.614
Postload Plasma Glucose, mg/dl	99 ± 20	125 ± 18*	0.02
HOMA-IR	1.44 ± 0.68	1.38 ± 0.62	0.729
Total cholesterol, mg/dl	172 ± 27	187 ± 30*	0.01
HDL cholesterol, mg/dl	68 ± 16	66 ± 17	0.717
LDL cholesterol, mg/dl	89 ± 17	109 ± 14*	<0.01
Non-HDL cholesterol, mg/dL	104 ± 17	129 ± 19*	<0.01
Triglycerides, mg/dl	67 ± 26	104 ± 37*	<0.01
Fibrinogen mg/dl	265 ± 50	340 ± 21*	<0.01

BP = blood pressure. *p <0.05 or p <0.01 related to Young Controls. Reference values: Fasting glucose <99 mg/dl; fasting insulin <13μUI/ml; Post load plasma glucose <140 mg/dl; Total cholesterol <240 mg/dl; triglycerides <150 mg/dl; high density lipoprotein (HDL-cholesterol) >40 mg/dl), respectively. Low density lipoprotein (LDL-cholesterol) was calculated using Friedewald’s equation¹⁷ using as reference value <130 mg/dl. Glucose and insulin levels were measured by enzymatic-colorimetric without pretreatment (reference value <99 mg/dl) and automated chemiluminescent methods (reference value <13μUI/ml), respectively. Homeostasis model assessment of insulin resistance (HOMA-IR) index was calculated as fasting insulin (mU/l) x fasting glucose/22.5 (reference value 2.1 ± 0.7)²⁴. High-sensitivity C-reactive protein determination was obtained by nephelometry method (reference value <0.5 for inflammatory process and < 0.11 for cardiovascular risk assessment). Fibrinogen was determined by coagulometric method (reference values between 200 and 400 mg/dl).

ISSN: 1471-2318