The association of APOE genotype and cognitive decline in interaction with risk factors in a 65–69 year old community sample

Table 4 Multivariate models of change scores excluding mild cognitive disorders

	SDMT		Immediate recall		Delayed recall		Digits Backwards		MMSE		Simple RT		Choice RT
	F	p	F	p	F	p	F	p	F	p	F	p	F	p
APOE Genotype	2.56	0.077	0.48	0.617	1.95	0.142	2.09	0.124	3.55	0.029	0.09	0.916	0.20	0.819
Education	2.83	0.037	0.94	0.422	1.13	0.337	1.53	0.206	3.20	0.023	0.25	0.863	0.61	0.605
Head injury	0.05	0.830	0.00	0.969	0.03	0.866	0.88	0.349	5.88	0.015	0.06	0.808	0.53	0.466
Premorbid intelligence	0.02	0.976	0.13	0.880	1.97	0.140	1.39	0.250	0.21	0.814	0.05	0.950	0.06	0.946
Genotype × Education	1.08	0.370	2.41	0.025	3.59	0.002	1.58	0.150	1.16	0.323	1.15	0.331	1.01	0.415
Genotype × Head injury	3.24	0.039	0.35	0.702	0.85	0.426	0.46	0.633	4.09	0.017	0.03	0.972	0.20	0.823
Genotype × Premorbid intelligence	0.59	0.667	0.90	0.462	1.84	0.119	1.09	0.360	1.26	0.284	2.95	0.019	0.40	0.806
Education × Head injury	2.24	0.081	0.80	0.495	0.16	0.922	1.38	0.246	3.22	0.022	0.37	0.774	0.26	0.852
Education × Premorbid intelligence	1.80	0.095	0.76	0.602	0.65	0.686	0.72	0.634	0.86	0.520	1.11	0.353	0.59	0.739
Head injury × Premorbid intelligence	0.44	0.647	0.45	0.639	0.35	0.708	0.92	0.398	0.02	0.982	0.58	0.557	0.95	0.387

Bold p-values represent p < .05; Underlined p-values indicate tests which change from significant to non-significant or vice versa when participants with mild cognitive disorders are excluded

ISSN: 1471-2318