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Table 1 Inclusion criteria

From: Protocol for Project FACT: a randomised controlled trial on the effect of a walking program and vitamin B supplementation on the rate of cognitive decline and psychosocial wellbeing in older adults with mild cognitive impairment [ISRCTN19227688]

Criteria for MCI (1–4) and other inclusion criteria for the RCT (5–11)
1. self reported memory complaints (answer yes to question 'do you have memory complaints', or at least twice sometimes at cognition scale of Strawbridge)
2. no report of disability in activities of daily living on GARS-scale, except on the item 'taking care of feet and toe nails'
3. objective memory impairment; 10 wlt delayed recall ≤5 + percentage savings ≤ 100
4. normal general cognitive functioning/absence of dementia; TICS ≥ 19
5. being able to moderate intensive physical activity without making use of walking devices, e.g. rollator, of walking frame
6. not using vitamin supplements/vitamin injections/drinks with dose of vitamin B6, B11 or B12 comparable to vitamin supplement given in intervention
7. not suffering from epilepsy, multiple sclerosis, Parkinson's disease, kidney disorder requiring haemodialysis, psychiatric impairment
8. not suffering from depression as measured by the Geriatric Depression Scale (cut off ≤ 5)
9. not using medication for rheumatoid arthritis or psoriasis interfering with vitamin supplement
10. no alcohol abuse (men < 21 consumptions a week, women < 15 consumptions a week)
11. not currently living in or on a waiting list for a nursing home