Table 1 Inclusion criteria
Criteria for MCI (1–4) and other inclusion criteria for the RCT (5–11) |
|---|
1. self reported memory complaints (answer yes to question 'do you have memory complaints', or at least twice sometimes at cognition scale of Strawbridge) |
2. no report of disability in activities of daily living on GARS-scale, except on the item 'taking care of feet and toe nails' |
3. objective memory impairment; 10 wlt delayed recall ≤5 + percentage savings ≤ 100 |
4. normal general cognitive functioning/absence of dementia; TICS ≥ 19 |
5. being able to moderate intensive physical activity without making use of walking devices, e.g. rollator, of walking frame |
6. not using vitamin supplements/vitamin injections/drinks with dose of vitamin B6, B11 or B12 comparable to vitamin supplement given in intervention |
7. not suffering from epilepsy, multiple sclerosis, Parkinson's disease, kidney disorder requiring haemodialysis, psychiatric impairment |
8. not suffering from depression as measured by the Geriatric Depression Scale (cut off ≤ 5) |
9. not using medication for rheumatoid arthritis or psoriasis interfering with vitamin supplement |
10. no alcohol abuse (men < 21 consumptions a week, women < 15 consumptions a week) |
11. not currently living in or on a waiting list for a nursing home |