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Table 1 Cochrane review data used as the basis for this analysis

From: Rational choice of cholinesterase inhibitor for the treatment of Alzheimer's disease in Canada: a comparative economic analysis

 

Donepezil

Rivastigmine

Galantamine

Daily dose

5 mg

10 mg

1–4 mg

6–12 mg

16 mg

24 mg

Efficacy*

-1.86

-2.90

-0.84

-2.09

-3.10

-3.29

   95% CI

-2.60, -1.11

-3.65,-2.16

-1.48, -0.19

-2.65, -1.54

-4.13, -2.07

-3.92, -2.65

Beta†

-0.071

-0.106

-0.036

-0.091

-0.105

-0.124

   95% CI

-0.099, -0.042

-0.133, -0.079

-0.067, -0.008

-0.115, -0.067

-0.14 -0.070

-0.147, -0.100

Withdrawal‡

1.02

1.36

1.01

1.95

1.34

1.51

   95% CI

0.78, 1.33

1.10,1.70

0.80, 1.27

1.65, 2.32

0.95, 1.89

1.23, 1.87

  1. * measured in terms of the weighted difference in mean cognitive change on the ADAS-cog comparing treatment to placebo † coefficient for variable effect analysis calculated as the efficacy divided by the mean baseline score ‡ relative risk of withdrawing from treatment, compared to placebo patients