Table 4 Discriminant validity of Mindstreams computerized tests: summary statistics and group differences (Mann-Whitney U).
From: Validity of a novel computerized cognitive battery for mild cognitive impairment
Cognitive Domain | Mindstreams Test (outcome parameter) | Healthy Elderly N = 39 | MCI N = 30 | Mild AD N = 29 | MCI / Healthy Elderly p-value | MCI / Mild AD p-value |
|---|---|---|---|---|---|---|
MEMORY | Verbal Memory (accuracy, first repetition trial) | 71.35 (18.88) | 48.21 (22.94) | 24.00 (20.41) | 0.000 | 0.000 |
| Â | Verbal Memory (accuracy, second repetition trial) | 87.37 (13.09) | 60.71 (25.08) | 23.60 (23.96) | 0.000 | 0.000 |
| Â | Verbal Memory (accuracy, third repetition trial) | 94.47 (7.60) | 71.43 (29.9) | 20.80 (22.16) | 0.000 | 0.000 |
| Â | Verbal Memory Accuracy (accuracy, final repetition trial) | 97.37 (5.54) | 73.21 (29.07) | 22.00 (23.8) | 0.000 | 0.000 |
| Â | Verbal Memory (accuracy, all repetition trials) | 88.08 (8.51) | 63.68 (24.13) | 22.76 (21.72) | 0.000 | 0.000 |
| Â | Verbal Memory (accuracy, delayed recognition) | 87.30 (12.17) | 62.50 (30.26) | 18.40 (19.30) | 0.000 | 0.000 |
| Â | Non-Verbal Memory (accuracy, first repetition trial) | 49.92 (21.25) | 38.71 (15.61) | 27.96 (16.35) | 0.027 | 0.017 |
| Â | Non-Verbal Memory (accuracy, second repetition trial) | 63.11 (20.63) | 46.68 (25.91) | 30.13 (13.95) | 0.006 | 0.014 |
| Â | Non-Verbal Memory (accuracy, third repetition trial) | 74.89 (23.65) | 55.18 (27.44) | 30.74 (17.98) | 0.003 | 0.002 |
| Â | Non-Verbal Memory Accuracy (accuracy, final repetition trial) | 82.84 (18.19) | 55.64 (28.36) | 28.92 (15.33) | 0.000 | 0.000 |
| Â | Non-Verbal Memory (accuracy, all repetition trials) | 67.79 (17.17) | 49.21 (20.36) | 28.96 (11.24) | 0.000 | 0.000 |
| Â | Non-Verbal Memory (accuracy, delayed recognition) | 74.92 (21.92) | 55.14 (25.00) | 37.68 (17.65) | 0.002 | 0.012 |
EXECUTIVE FUNCTION | Go-NoGo (accuracy) | 94.28 (6.59) | 84.89 (18.93) | 81.90 (14.19) | 0.001 | 0.238 |
| Â | Go-NoGo (performance index) | 20.55 (2.63) | 16.47 (3.75) | 13.68 (4.77) | 0.000 | 0.036 |
| Â | Problem Solving (accuracy) | 73.45 (15.27) | 61.36 (13.09) | 55.00 (15.62) | 0.000 | 0.161 |
| Â | Stroop Interference (performance index) | 11.70 (6.40) | 7.16 (5.38) | --- | 0.023 | --- |
| Â | Catch Game (accuracy) | 59.67 (14.91) | 46.24 (19.80) | --- | 0.016 | --- |
VISUAL SPATIAL | Visual Spatial Imagery (accuracy) | 60.16 (15.61) | 44.37 (15.53) | 35.56 (15.43) | 0.000 | 0.015 |
VERBAL | Verbal Function (accuracy, naming) | 92.33 (8.79) | 83.22 (14.05) | 66.96 (18.37) | 0.004 | 0.002 |
| Â | Verbal Function (accuracy, rhyming) | 80.38 (16.97) | 52.21 (29.36) | 37.79 (22.79) | 0.000 | 0.02 |
ATTENTION | Go-NoGo (RT) | 464.39 (56.66) | 556.04 (102.82) | 666.38 (243.81) | 0.000 | 0.244 |
| Â | Go-NoGo (standard deviation of RT) | 119.17 (46.40) | 171.96 (89.02) | 242.81 (160.75) | 0.006 | 0.149 |
| Â | Choice Reaction Time (performance index) | 15.84 (3.84) | 15.52 (5.51) | 9.34 (4.41) | 0.894 | 0.004 |
INFORMATION PROCESSING | Staged Information Processing, Low Load (performance index) | 15.21 (1.91) | 14.52 (2.28) | --- | 0.345 | --- |
| Â | Staged Information Processing, Medium Load (performance index) | 8.83 (1.55) | 7.04 (1.75) | --- | 0.001 | --- |
| Â | Staged Information Processing, High Load (performance index) | 5.55 (1.16) | 4.71 (1.51) | --- | 0.037 | --- |
MOTOR SKILLS | Finger Tapping (inter-tap interval) | 221.10 (42.71) | 242.83 (64.88) | 279.00 (66.09) | 0.215 | 0.055 |
| Â | Finger Tapping (standard deviation of inter-tap interval) | 38.38 (28.82) | 58.35 (49.46) | 66.62 (78.09) | 0.101 | 0.888 |
| Â | Catch Game (time to first move) | 774.91 (158.10) | 783.14 (169.16) | --- | 0.797 | --- |