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Table 4 Accuracy of phalangeal RA in predicting osteoporosis

From: Calcaneal quantitative ultrasound and Phalangeal radiographic absorptiometry alone or in combination in a triage approach for assessment of osteoporosis: a study of older women with a high prevalence of falls

Phalangeal RA (n = 245) Youden1 UK-NOS triage approach 90% certainty level UK-NOS triage approach 95% certainty level
RA T-score Upper/lower cutoff -2.22 -0.65/–2.95 0.28/–3.32
Sensitivity (95% CI) 67.6 (57.9–76.3) 90.7 (83.6–95.5) 95.4 (89.5–98.5)
Specificity (95% CI) 78.1 (70.2–84.7) 90.5 (84.3–94.9) 95.6 (90.7–98.4)
PPV (95% CI) 70.9 (61.1–79.4) 75.0 (61.1–86) 82.9 (66.4–93.4)
NPV (95% CI) 75.4 (67.4–82.2) 81.1 (68–90.6) 77.3 (54.6–92.2)
False negative n (%) 35 (14.3) 10 (4.1) 5 (2.0)
False positive n (%) 30 (12.2) 13 (5.3) 6 (2.5)
DXA scans avoided n (%) NA 105 (42.9) 57 (23.3)
  1. Accuracy of phalangeal RA in predicting osteoporosis applying the optimal cutoff and UK-NOS triage approach at 90% and 95% certainty levels. 1the optimal cutoff calculated according the Youden index [30]. Abbreviations: RA Radiographic Absorptiometry, UK-NOS United Kingdom National Osteoporosis Society, PPV Positive Predictive Value, NPV Negative Predictive Value, DXA Dual Energy X-ray Absorptiometry, CI Confidence Interval, NA not available.