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1
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Was the rationale of the research described?
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2
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Were the objectives of the research clearly stated?
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3
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Was the study a prospective cohort study?
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4
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Was the follow-up of the cohort study 5 years or longer?
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5
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Were the key-elements of the study design described?
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6
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Were the setting, relevant dates and timeframe of the research described?
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7
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Were the eligibility criteria for participants described?
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8
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Were the participants free of disability at baseline?
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9
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Were the predictors and dependent variables described?
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10
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Were the measurement methods for the predictors and dependent variables described?
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11
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Were standardized or valid measurements used for the predictors?
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12
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Were standardized or valid measurements used for the outcome?
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13
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Were potential types of bias addressed?
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14
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Was it clear how the quantitative data were handled in the analyses?
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15
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Were appropriate multivariate analysis techniques used?
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16
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Did the statistical methods control for confounding and examine subgroups or interactions?
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17
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Was there a description on how the final number of participants was established?
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18
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Was the (loss to) follow-up of the participants described?
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19
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Was the attrition less than 20%?
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20
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Was information provided regarding the baseline characteristics of participants?
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21
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Was the number of outcome events or summary measures over time reported?
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22
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Were the results expressed in an Odds Ratio (OR), Risk Ratio (RR) or Hazard Ratio (HR) with the corresponding 95% confidence interval?
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23
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If sub-group analyses were performed, were these clearly described?
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24
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Were the key-results described in the discussion?
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25
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Were the limitations of the study reported?
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26
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Were previous research and the limitations of the study taken into account when an overall interpretation of the study results was provided?
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27
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Was the generalisability of the study results described?
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