Study of Mental Activity and Regular Training (SMART) in at risk individuals: A randomised double blind, sham controlled, longitudinal trial

Table 7 Secondary outcomes continued: neuroimaging

Outcome	Measure	Description
Structural MRI: T1-weighted Whole Brain Measures	1. Voxel Based Morphometry	A combination of different software packages will be used for automated and semi-automated computational neuroanatomical analyses, in addition to expert manual tracing of hippocampus and entorhinal cortex.
	2. Cortical thickness
	3. Whole brain volume
	4. GM volume
	5. WM volume
	6. CSF volume
Regional Measures	1. Automated regional cortical volume measures
	2. Manually traced subcortical volumes
FLAIR-weighted MRI	White matter hyperintensity volume	Automated measure of white matter disease load
Magnetic Resonance Spectroscopy (MRS) Relative measures of :	1. N-acetylaspartate (NAA)	Measures of different brain metabolites using MR spectroscopy in the hippocampus and posterior cingulate grey matter.
	2. Cholines
	3. Myo-inositol
	4. Creatine+Phosphocreatine
Resting State functional MRI	1. Bilateral hippocampal connectivity	Seed-based correlational analysis and Independent Component Analysis will be used to characterise individuals' resting state BOLD time series.
	2. Hippocampus functional connectivity map
	3. Posterior cingulate functional connectivity map
	4. Default Mode Network (DMN)
	5. DMN-anticorrelations

ISSN: 1471-2318