Skip to main content

Table 1 Inclusion and exclusion criteria for the SMART trial

From: Study of Mental Activity and Regular Training (SMART) in at risk individuals: A randomised double blind, sham controlled, longitudinal trial

Inclusion criteria Exclusion criteria
Age ≥ 55
Competency in English sufficient for assessment and training
MMSE^ 23-29
CDR^^ ≤ 1.0
TICS #< 30
No unstable disease precluding planned exercise*
Absence of significant cognitive decline in 5 years
Absence of known organic or psychiatric condition affecting cognition
Able to see and hear sufficiently to participate in planned physical and computer-based cognitive training
Unstable medical condition*
Participation in any cognitive training activity
Participation in > 150 min/wk of moderate or greater intensity planned exercise of any kind
Rapidly progressive or terminal illness
Pre-existing diagnosis of dementia
Psychotic illness (DSM-IV)**
Degenerative neurological disorder
Diagnosis of stroke or TIA+ within last 12 months, stroke with residual neurological deficit, two or more strokes or TIAs at anytime, One stroke or TIA with residual deficits that preclude participation.
TBI ± within past year, or with residual deficits that preclude participation.
Diagnosis of depression (DSM-IV) GDS++ >9 or current treatment with antidepressant medications, greater than 3 episodes of depression in the last 5 years ("episode": requiring treatment), > 10 episodes requiring treatment over lifetime, past suicide attempts, current bipolar diagnosis and treatment, > 3 past episodes requiring treatment in last 5 years.
Current alcohol or drug abuse (DSM-IV)
Unrepaired abdominal or other known aneurysm
Myocardial infarction or cardiac surgery within past 6 months
Unstable angina or uncontrolled malignant arrhythmias at rest or on exercise stress testing
Recent retinal haemorrhage or detachment/proliferative retinopathy
Seizures (>2 in past 12 months)
  1. * Examples of unstable conditions include uncontrolled arrhythmias, hypertension, hyperglycemia, symptomatic enlarging hernia, acute pulmonary embolism, deep venous thrombosis, recent or unstable fracture, inflammatory or traumatic joint injuries, etc. Such individuals may become eligible if medical or surgical treatment stabilizes their condition.
  2. ^ MMSE Mini Mental Status Examination 27
  3. ^^ CDR Clinical Dementia Rating 26
  4. #TICS Telephone Interview for Cognitive Status -Modified 30
  5. **DSM-IV Diagnostic and Statistical Manual of Mental Disorders 4th edition
  6. + TIA Trans Ischemic Attack
  7. ± TBI Traumatic brain Injury
  8. ++ GDS Geriatric Depression Scale [49]
  9. ±±NYHA Class IV CHF New York Heart Association Class IV Class of Heart Failure indicating symptoms evident at rest with any physical activity increasing symptoms, precluding ability to complete physical activity and causing severe limitations.