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Neurology, stroke and cognition

Section edited by Pieter Jelle Visser

This section considers manuscripts on all neurological topics. Including: Alzheimer’s, cognition, stroke, dementia, wandering behaviours.

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  1. Content type: Research Article

    Sunlight exposure and high vitamin D status have been hypothesised to reduce the risk of developing dementia. The objective of our research was to determine whether lack of sunlight and hypovitaminosis D over ...

    Authors: Isolde Sommer, Ursula Griebler, Christina Kien, Stefanie Auer, Irma Klerings, Renate Hammer, Peter Holzer and Gerald Gartlehner

    Citation: BMC Geriatrics 2017 17:16

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  2. Content type: Study protocol

    Frequent hospitalization and permanent nursing home placement not only affect the well-being of persons with dementia, but also place great financial strain on society. Therefore, it is important to create eff...

    Authors: Sophie Vandepitte, Nele Van Den Noortgate, Koen Putman, Sofie Verhaeghe and Lieven Annemans

    Citation: BMC Geriatrics 2016 16:207

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  3. Content type: Research Article

    Alzheimer’s disease (AD), the commonest cause of dementia, represents a significant cost to UK society. This analysis describes resource utilisation, costs and clinical outcomes in non-institutionalised patien...

    Authors: Alan Lenox-Smith, Catherine Reed, Jeremie Lebrec, Mark Belger and Roy W. Jones

    Citation: BMC Geriatrics 2016 16:195

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  4. Content type: Research Article

    Bilingualism may protect against cognitive aging and delay the onset of dementia. However, studies comparing monolinguals and bilinguals on such metrics have produced inconsistent results complicated by confou...

    Authors: Claudia Padilla, Mario F. Mendez, Elvira E. Jimenez and Edmond Teng

    Citation: BMC Geriatrics 2016 16:189

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  5. Content type: Research Article

    The discrepancy between the number of admissions and the allocation of hospital beds means that many patients admitted to hospital can be placed in units or wards other than that which specialise in the patien...

    Authors: Lua Perimal-Lewis, Clare Bradley, Paul H. Hakendorf, Craig Whitehead, Louise Heuzenroeder and Maria Crotty

    Citation: BMC Geriatrics 2016 16:190

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  6. Content type: Research Article

    Subjective cognitive decline (SCD), i.e., the self-perceived feeling of worsening cognitive function, may be the first notable syndrome of preclinical Alzheimer’s disease and other dementias. However, not all ...

    Authors: Susanne Roehr, Arno Villringer, Matthias C. Angermeyer, Tobias Luck and Steffi G. Riedel-Heller

    Citation: BMC Geriatrics 2016 16:180

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  7. Content type: Research article

    Few studies have investigated factors associated with depression among elderly people with and without stroke concurrently, using identical settings, procedures and study variables. The aim was to investigate ...

    Authors: Carl Hörnsten, Hugo Lövheim, Peter Nordström and Yngve Gustafson

    Citation: BMC Geriatrics 2016 16:174

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  8. Content type: Research Article

    Most patients with dementia or cognitive impairment receive care from family members, often untrained for this challenging role. Caregivers may not access publicly available caregiving information, and caregiv...

    Authors: Kendra Peterson, Howard Hahn, Amber J. Lee, Catherine A. Madison and Alireza Atri

    Citation: BMC Geriatrics 2016 16:164

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  9. Content type: Research Article

    Older people are commonly prescribed multiple medications, including medications with anticholinergic effects. Polypharmacy and anticholinergic medications may be risk factors for the development of delirium.

    Authors: Hannah C. Moorey, Sebastian Zaidman and Thomas A. Jackson

    Citation: BMC Geriatrics 2016 16:162

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  10. Content type: Research Article

    Age increases the risk of mortality and poor prognosis following stroke. The benefit of intravenous thrombolysis in very old patients remains uncertain. The purpose of the study was to evaluate the efficacy an...

    Authors: S. Sagnier, P. Galli, M. Poli, S. Debruxelles, P. Renou, S. Olindo, F. Rouanet and I. Sibon

    Citation: BMC Geriatrics 2016 16:156

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  11. Content type: Research Article

    To examine whether delirium in hip fracture patients was associated with changes in the levels of amino acids and/or monoamine metabolites in cerebrospinal fluid (CSF) and serum.

    Authors: Leiv Otto Watne, Ane-Victoria Idland, Durk Fekkes, Johan Raeder, Frede Frihagen, Anette Hylen Ranhoff, Farrukh Abbas Chaudhry, Knut Engedal, Torgeir Bruun Wyller and Bjørnar Hassel

    Citation: BMC Geriatrics 2016 16:149

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  12. Content type: Research article

    There are knowledge gaps about the life situation for people ageing with Parkinson’s disease (PD), with virtually no understanding of home and health dynamics. Therefore, the aim of the present study was to ex...

    Authors: Maria H. Nilsson, Susann Ullén, Henrik Ekström and Susanne Iwarsson

    Citation: BMC Geriatrics 2016 16:146

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  13. Content type: Research Article

    Assisting a person with dementia can lead to significant carer burden and possible negative outcomes for the person. Using the Delphi method, this study developed expert consensus guidelines for how family and...

    Authors: K. S. Bond, A. F. Jorm, B. A. Kitchener, C. M. Kelly and K. J. Chalmers

    Citation: BMC Geriatrics 2016 16:129

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  14. Content type: Research article

    There are various definitions and diagnostic criteria for dementia, leading to discrepancies in case ascertainment in both clinical practice and research. We reviewed the different definitions, approaches and ...

    Authors: Rebecca Palm, Saskia Jünger, Sven Reuther, Christian G. G. Schwab, Martin N. Dichter, Bernhard Holle and Margareta Halek

    Citation: BMC Geriatrics 2016 16:78

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  15. Content type: Research article

    Existing everyday technology as well as potential future technology may offer both challenges and possibilities in the everyday occupations of persons with cognitive decline. To meet their wishes and needs, th...

    Authors: Annicka Hedman, Eva Lindqvist and Louise Nygård

    Citation: BMC Geriatrics 2016 16:73

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  16. Content type: Research article

    This project Smart Assisted Living involving Informal careGivers++ (SALIG) intends to develop an ICT-based device for persons with cognitive impairment combined with remote support possibilities for significan...

    Authors: Inga-Lill Boman, Ann-Christine Persson and Aniko Bartfai

    Citation: BMC Geriatrics 2016 16:61

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  17. Content type: Research article

    Muscle wasting and obesity may complicate the post-stroke trajectory. We investigated the relationships between nutritional status, body composition, and mobility one to 3 years after stroke.

    Authors: Birgit Vahlberg, Lena Zetterberg, Birgitta Lindmark, Karin Hellström and Tommy Cederholm

    Citation: BMC Geriatrics 2016 16:48

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  18. Content type: Research article

    We analyzed the associations between diabetes and cognitive impairment (CI) and dependence in a population of patients 65 years or older.

    Authors: Emiliano Rodríguez-Sánchez, Sara Mora-Simón, María C. Patino-Alonso, Diana Pérez-Arechaederra, José I. Recio-Rodríguez, Manuel A. Gómez-Marcos, Luis F. Valero-Juan and Luis García-Ortiz

    Citation: BMC Geriatrics 2016 16:33

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  19. Content type: Research article

    The neural mechanisms underlying the restorative effects of cognitive training on aging brains remain unclear. To address this issue, we examined the relationship between changes in spontaneous brain activity ...

    Authors: Ting Li, Ye Yao, Yan Cheng, Bing Xu, Xinyi Cao, David Waxman, Wei Feng, Yuan Shen, Qingwei Li, Jijun Wang, Wenyuan Wu, Chunbo Li and Jianfeng Feng

    Citation: BMC Geriatrics 2016 16:12

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  20. Content type: Research article

    The interactive effect between diabetes and impaired kidney function on cognitive impairment in older adults has not yet been reported. The aim of this study was to investigate the association of diabetes and ...

    Authors: Zhaoxue Yin, Zhongrui Yan, Yajun Liang, Hui Jiang, Chuanzhu Cai, Aiqin Song, Lei Feng and Chengxuan Qiu

    Citation: BMC Geriatrics 2016 16:7

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  21. Content type: Research article

    Frailty and cognitive impairment are seemingly distinct syndromes, but have a shared vulnerability to stress in older adults, resulting in poorer outcomes. Although there has been recent interest in cognitive ...

    Authors: Mei Sian Chong, Laura Tay, Mark Chan, Wee Shiong Lim, Ruijing Ye, Eng King Tan and Yew Yoong Ding

    Citation: BMC Geriatrics 2015 15:175

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  22. Content type: Research article

    Current research has established obesity as one of the main modifiable risk factors for cognitive impairment. However, evidence on the relationships of total and regional body composition measures as well as s...

    Authors: Efstathios Papachristou, Sheena E. Ramsay, Lucy T. Lennon, Olia Papacosta, Steve Iliffe, Peter H. Whincup and S. Goya Wannamethee

    Citation: BMC Geriatrics 2015 15:172

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  23. Content type: Research article

    We have previously described the development of the Identification and Intervention for Dementia in Elderly Africans (IDEA) cognitive screen for use in populations with low levels of formal education. The IDEA...

    Authors: Stella-Maria Paddick, William K Gray, Luqman Ogunjimi, Bingileki lwezuala, Olaide Olakehinde, Aloyce Kisoli, John Kissima, Godfrey Mbowe, Sarah Mkenda, Catherine L Dotchin, Richard W Walker, Declare Mushi, Cecilia Collingwood and Adesola Ogunniyi

    Citation: BMC Geriatrics 2015 15:53

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  24. Content type: Study protocol

    Delirium affects 15% of hospitalised patients and is linked with poor outcomes, yet few pharmacological treatment options exist. One hypothesis is that delirium may in part result from exaggerated and/or prolo...

    Authors: Bjørn Erik Neerland, Karen Roksund Hov, Vegard Bruun Wyller, Eirik Qvigstad, Eva Skovlund, Alasdair MJ MacLullich and Torgeir Bruun Wyller

    Citation: BMC Geriatrics 2015 15:7

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  25. Content type: Research article

    Mobility problems and cognitive deficits related to transferring or moving persons suffering from dementia are associated with dependency. Physical assistance provided by staff is an important component of res...

    Authors: Charlotta Thunborg, Petra von Heideken Wågert, Eva Götell, Ann-Britt Ivarsson and Anne Söderlund

    Citation: BMC Geriatrics 2015 15:6

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  26. Content type: Research article

    In many countries, primary care physicians determine whether or not older drivers are fit to drive. Little, however, is known regarding the effects of cognitive decline on driving performance and the means to ...

    Authors: Paul Vaucher, Daniela Herzig, Isabel Cardoso, Michael H Herzog, Patrice Mangin and Bernard Favrat

    Citation: BMC Geriatrics 2014 14:123

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  27. Content type: Research article

    Non-pharmacological interventions are expected to be important strategies for reducing the age-adjusted prevalence of senile dementia, considering that complete medical treatment for cognitive decline has not ...

    Authors: Hiroyuki Suzuki, Masataka Kuraoka, Masashi Yasunaga, Kumiko Nonaka, Ryota Sakurai, Rumi Takeuchi, Yoh Murayama, Hiromi Ohba and Yoshinori Fujiwara

    Citation: BMC Geriatrics 2014 14:122

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  28. Content type: Study protocol

    Alzheimer’s disease is characterised by a loss of cognitive function and behavioural problems as set out in the term “Behavioural and Psychological Symptoms of Dementia”. These behavioural symptoms have heavy ...

    Authors: Isabelle Rouch, Jean-Michel Dorey, Nawèle Boublay, Marie-Anne Henaff, Florence Dibie-Racoupeau, Zaza Makaroff, Sandrine Harston, Michel Benoit, Marie-Odile Barrellon, Denis Fédérico, Bernard Laurent, Catherine Padovan and Pierre Krolak-Salmon

    Citation: BMC Geriatrics 2014 14:110

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  29. Content type: Study protocol

    Delirium is associated with substantial morbidity and mortality rates in elderly hospitalised patients, and a growing problem due to increase in life expectancy. Implementation of standardised non-pharmacologi...

    Authors: Edmée JM Schrijver, Oscar J de Vries, Astrid Verburg, Karola de Graaf, Pierre M Bet, Peter M van de Ven, Ad M Kamper, Sabine HA Diepeveen, Sander Anten, Andrea Siegel, Esther Kuipéri, Anne M Lagaay, Rob J van Marum, Astrid M van Strien, Leo Boelaarts, Douwe Pons…

    Citation: BMC Geriatrics 2014 14:96

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  30. Content type: Research article

    In the modern world with new family structures, international migration and increased life expectancy, there is a growing need for legal ways of assisting elderly with impaired mental capacity to decide about ...

    Authors: Karin S Björkstén, Kerstin Fälldin and Johanna Ulfvarson

    Citation: BMC Geriatrics 2014 14:94

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  31. Content type: Study protocol

    Recovery after stroke is dependent on how much time can be spent on rehabilitation. Recently, we found that therapy time for older stroke patients on a rehabilitation unit of a nursing home could be increased ...

    Authors: Marleen Huijben-Schoenmakers, Arno Rademaker, Peter van Rooden and Erik Scherder

    Citation: BMC Geriatrics 2014 14:68

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  32. Content type: Research article

    We tested the hypothesis that harm avoidance, a trait associated with behavioral inhibition, is associated with the rate of change in parkinsonism in older adults.

    Authors: Aron S Buchman, Lei Yu, Robert S Wilson, Joshua M Shulman, Patricia A Boyle and David A Bennett

    Citation: BMC Geriatrics 2014 14:54

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  33. Content type: Research article

    Persons with dementia might have considerable difficulties in using an ordinary telephone. Being able to use the telephone can be very important in order to maintain their social network, getting stimulation a...

    Authors: Inga-Lill Boman, Stefan Lundberg, Sofia Starkhammar and Louise Nygård

    Citation: BMC Geriatrics 2014 14:49

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  34. Content type: Research article

    Stroke complications can occur not only in the acute ward but also during the subsequent rehabilitation period. However, existing studies have not adequately addressed the incidence of various complications am...

    Authors: Chien-Min Chen, Hung-Chih Hsu, Chia-Hao Chang, Chu-Hsu Lin, Kai-Hua Chen, Wei-Chi Hsieh and Wen-Ming Chang

    Citation: BMC Geriatrics 2014 14:41

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  35. Content type: Research article

    Numerous studies indicate that the use of feeding tubes (FT) in persons with advanced cognitive impairment (CI) does not improve clinical outcomes or survival, and results in higher rates of hospitalization an...

    Authors: Caroline E Stephens, Nathan Sackett, Prasanthi Govindarajan and Sei J Lee

    Citation: BMC Geriatrics 2014 14:35

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  36. Content type: Study protocol

    Neuropsychiatric symptoms (NPS) frequently occur in patients with dementia. To date, prospective studies on the course of NPS have been conducted in patients with dementia in clinical centers or psychiatric se...

    Authors: Petra Borsje, Roland B Wetzels, Peter LBJ Lucassen, Anne-Margriet Pot and Raymond TCM Koopmans

    Citation: BMC Geriatrics 2014 14:32

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  37. Content type: Research article

    This study compared individuals whose clinical diagnosis of Alzheimer’s disease (AD) matched or did not match neuropathologic results at autopsy on clinical and functional outcomes (cognitive impairment, funct...

    Authors: Joseph E Gaugler, Haya Ascher-Svanum, David L Roth, Tolulope Fafowora, Andrew Siderowf and Thomas G Beach

    Citation: BMC Geriatrics 2013 13:137

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  38. Content type: Research article

    Coronary artery disease (CAD) is associated with verbal memory decline, although deterioration may be mitigated in individuals undertaking exercise interventions. Ceramide sphingolipids, suggested to play a ro...

    Authors: Mahwesh Saleem, Veera V Ratnam Bandaru, Nathan Herrmann, Walter Swardfager, Michelle M Mielke, Paul I Oh, Prathiba Shammi, Alexander Kiss, Norman J Haughey, Randal Rovinski and Krista L Lanctôt

    Citation: BMC Geriatrics 2013 13:135

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  39. Content type: Research article

    This scoping study aimed to identify how physical activity may benefit people with dementia; how and/or if current service provide these benefits; and what support they need to do so.

    Authors: Alison Bowes, Alison Dawson, Ruth Jepson and Louise McCabe

    Citation: BMC Geriatrics 2013 13:129

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  40. Content type: Correspondence

    The aim of this project was to develop a toolkit to assist persons with dementia (PWD) and their caregivers, in planning for retirement from driving. The information gathered was used to develop a tool that ca...

    Authors: Anna Byszewski, Faranek Aminzadeh, Kelly Robinson, Frank Molnar, William Dalziel, Malcolm Man Son Hing, Lynn Hunt and Shawn Marshall

    Citation: BMC Geriatrics 2013 13:117

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  41. Content type: Study protocol

    Developed countries are experiencing an unprecedented increase in life expectancy that is accompanied by a tremendous rise in the number of people with dementia. The purpose of this paper is to report on the s...

    Authors: Antonio Guaita, Mauro Colombo, Roberta Vaccaro, Silvia Fossi, Silvia Francesca Vitali, Gianluigi Forloni, Letizia Polito, Annalisa Davin, Virginia Valeria Ferretti and Simona Villani

    Citation: BMC Geriatrics 2013 13:98

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  42. Content type: Research article

    Poor self-rated health has been associated with poorer objective health outcomes across a range of conditions including stroke. Identification of factors associated with poor self-rated health in stroke surviv...

    Authors: Nahal Mavaddat, Rianne Van der Linde, George M Savva, Carol Brayne and Jonathan Mant

    Citation: BMC Geriatrics 2013 13:85

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  43. Content type: Research article

    Cognitive impairment is prevalent in older adults with heart failure (HF) and associated with reduced functional independence. HF patients appear at risk for reduced driving ability, as past work in other medi...

    Authors: Michael L Alosco, Mary Beth Spitznagel, Mary Jo Cleveland and John Gunstad

    Citation: BMC Geriatrics 2013 13:58

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  44. Content type: Study protocol

    Only half of those living with Alzheimer’s disease in France are currently diagnosed, and only one patient in three is supported during the early stages of dementia. This study aims to evaluate three cognitive...

    Authors: Christiane Vannier-Nitenberg, Virginie Dauphinot, Bienvenu Bongue, Catherine Sass, Isabelle Rouch, Olivier Beauchet, Pierre Krolak-Salmon and Bruno Fantino

    Citation: BMC Geriatrics 2013 13:55

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  45. Content type: Research article

    Treatment of Alzheimer’s disease with acetylcholinesterase inhibitors can result in symptomatic benefits, but patients often show variable responses. The objective of this post hoc analysis was to investigate ...

    Authors: Marwan Sabbagh, Jeffrey Cummings, Daniel Christensen, Rachelle Doody, Martin Farlow, Liang Liu, Joan Mackell and Randi Fain

    Citation: BMC Geriatrics 2013 13:56

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