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Neurology, stroke and cognition

Section edited by Pieter Jelle Visser

This section considers manuscripts on all neurological topics. Including: Alzheimer’s, cognition, stroke, dementia, wandering behaviours.

Page 1 of 3

  1. Content type: Research article

    The risk-benefit relationship of memantine treatment for Alzheimer’s disease (AD) remains unclear. In addition, variability between the results of clinical trials has been observed. The aim of this study was t...

    Authors: Lídia Blanco-Silvente, Dolors Capellà, Josep Garre-Olmo, Joan Vilalta-Franch and Xavier Castells

    Citation: BMC Geriatrics 2018 18:168

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  2. Content type: Study protocol

    Late-life cognitive decline, caused by progressive neuronal loss leading to brain atrophy years before symptoms are detected, is expected to double in Canada over the next two decades. Cognitive impairment in ...

    Authors: Sana Tariq, Christopher D. d’Esterre, Tolulope T. Sajobi, Eric E. Smith, Richard Stewart Longman, Richard Frayne, Shelagh B. Coutts, Nils D. Forkert and Philip A. Barber

    Citation: BMC Geriatrics 2018 18:163

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  3. Content type: Research article

    The Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE) is widely used as a complementary screening tool for dementia. However, there are few studies concerning the efficacy of the IQCODE for ...

    Authors: Yunlong Ding, Jiali Niu, Yanrong Zhang, Wenpeng Liu, Yan Zhou, Can Wei and Yan Liu

    Citation: BMC Geriatrics 2018 18:146

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  4. Content type: Research article

    Alzheimer’s disease (AD) dementia, a progressive neurodegenerative disease, exerts significant burden upon patients, caregivers, and healthcare systems globally. The current study investigated the associations...

    Authors: William Montgomery, Amir Goren, Kristin Kahle-Wrobleski, Tomomi Nakamura and Kaname Ueda

    Citation: BMC Geriatrics 2018 18:141

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  5. Content type: Research article

    Community health professionals play a significant role in dementia care. However, little is known about community health professionals’ capacity in dementia care, especially in low and middle-income countries....

    Authors: Yao Wang, Lily Dongxia Xiao, Yang Luo, Shui-Yuan Xiao, Craig Whitehead and Owen Davies

    Citation: BMC Geriatrics 2018 18:122

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  6. Content type: Research article

    Vascular risk factors increase the risk of Alzheimer’s disease (AD), but there is limited evidence on whether comorbid vascular conditions and risk factors have an impact on disease progression. The aim of thi...

    Authors: Rannveig Sakshaug Eldholm, Karin Persson, Maria Lage Barca, Anne-Brita Knapskog, Lena Cavallin, Knut Engedal, Geir Selbaek, Eva Skovlund and Ingvild Saltvedt

    Citation: BMC Geriatrics 2018 18:120

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  7. Content type: Study protocol

    There are effective non-pharmacological treatment programs that reduce functional disability and changed behaviours in people with dementia. However, these programs (such as the Care of People with dementia in...

    Authors: Lindy Clemson, Kate Laver, Yun-Hee Jeon, Tracy A Comans, Justin Scanlan, Miia Rahja, Jennifer Culph, Lee-Fay Low, Sally Day, Monica Cations, Maria Crotty, Susan Kurrle, Catherine Piersol and Laura N. Gitlin

    Citation: BMC Geriatrics 2018 18:108

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  8. Content type: Research Article

    Self-rated health predicts health outcomes independently of levels of disability or mood. Little is known about what influences the subjective health experience of stroke survivors. Our aim was to investigate ...

    Authors: N. Mavaddat, E. Sadler, L. Lim, K. Williams, E. Warburton, A. L. Kinmonth, J. Mant, J. Burt and C. McKevitt

    Citation: BMC Geriatrics 2018 18:81

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  9. Content type: Research article

    Many older adults have low levels of health literacy which affects their ability to participate optimally in healthcare. It is unclear how cognitive decline contributes to health literacy. To study this, longi...

    Authors: Bas Geboers, Ellen Uiters, Sijmen A. Reijneveld, Carel J. M. Jansen, Josué Almansa, Astrid C. J. Nooyens, W. M. Monique Verschuren, Andrea F. de Winter and H. Susan J. Picavet

    Citation: BMC Geriatrics 2018 18:77

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  10. Content type: Research Article

    It has been suggested that tooth loss in later life might increase dementia incidence. The objective of this analysis is to systematically review the current evidence on the relationship between the number of ...

    Authors: Bumjo Oh, Dong-Hun Han, Kyu-Tae Han, Xibei Liu, Johnson Ukken, Carina Chang, Kiki Dounis and Ji Won Yoo

    Citation: BMC Geriatrics 2018 18:48

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  11. Content type: Research Article

    Elderly persons with a dementia diagnosis often suffer from different neuropsychiatric symptoms (NPS) such as delusions, hallucinations, depression, anxiety, irritability and agitation. Currently, the medical ...

    Authors: Iris Zahirovic, Gustav Torisson, Carina Wattmo and Elisabet Londos

    Citation: BMC Geriatrics 2018 18:50

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  12. Content type: Research article

    Cognitive impairment places older adults at high risk of functional disability in their daily-life activities, and thus affecting their quality of life. This study aimed to examine the effects of Tai Chi on ge...

    Authors: Mei-yi Siu and Diana T. F. Lee

    Citation: BMC Geriatrics 2018 18:37

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  13. Content type: Research Article

    Identifying how persons with dementia experience lived space is important for enabling supportive living environments and creating communities that compensate for the fading capabilities of these persons. Seve...

    Authors: Linn Hege Førsund, Ellen Karine Grov, Anne-Sofie Helvik, Lene Kristine Juvet, Kirsti Skovdahl and Siren Eriksen

    Citation: BMC Geriatrics 2018 18:33

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  14. Content type: Study protocol

    Given the world’s aging population, it is important to identify strategies that promote healthy cognitive aging and minimize cognitive decline. Currently, no curative pharmaceutical therapy exists for cognitiv...

    Authors: Lisanne F. ten Brinke, John R. Best, Rachel A. Crockett and Teresa Liu-Ambrose

    Citation: BMC Geriatrics 2018 18:31

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  15. Content type: Research article

    Delirium increases the risk of mortality during an acute hospital admission. Full syndromal delirium (FSD) is associated with greatest risk and subsyndromal delirium (SSD) is associated with intermediate risk,...

    Authors: R. A. Diwell, D.H. Davis, V. Vickerstaff and E. L. Sampson

    Citation: BMC Geriatrics 2018 18:24

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  16. Content type: Research article

    Medications are frequently reported as both predisposing factors and inducers of delirium. This review evaluated the available evidence and determined the magnitude of risk of postoperative delirium associated...

    Authors: Gizat M. Kassie, Tuan A. Nguyen, Lisa M. Kalisch Ellett, Nicole L. Pratt and Elizabeth E. Roughead

    Citation: BMC Geriatrics 2017 17:298

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  17. Content type: Research Article

    Several previous studies reported social participation may reduce the incident of dementia; therefore, the type of positions held in the organization may relate to dementia onset. However, this hypothesis rema...

    Authors: Yuta Nemoto, Tami Saito, Satoru Kanamori, Taishi Tsuji, Kokoro Shirai, Hiroyuki Kikuchi, Kazushi Maruo, Takashi Arao and Katsunori Kondo

    Citation: BMC Geriatrics 2017 17:297

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  18. Content type: Research Article

    Reduced level of arousal is commonly observed in medical admissions and may predict in-hospital mortality. Delirium and reduced level of arousal are closely related. We systematically reviewed and conducted a ...

    Authors: Amy Todd, Samantha Blackley, Jennifer K. Burton, David J. Stott, E. Wesley Ely, Zoë Tieges, Alasdair M. J. MacLullich and Susan D. Shenkin

    Citation: BMC Geriatrics 2017 17:283

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  19. Content type: Research Article

    Anxiety and depression are common in Parkinson disease and both are important determinants of quality of life in patients. Several risk factors are identified but few research have investigated general and Par...

    Authors: Shi-Shuang Cui, Juan-Juan Du, Rao Fu, Yi-Qi Lin, Pei Huang, Ya-Chao He, Chao Gao, Hua-Long Wang and Sheng-Di Chen

    Citation: BMC Geriatrics 2017 17:270

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  20. Content type: Research Article

    Dementia imposes a high burden of disease worldwide. Recent epidemiological studies in European community samples are scarce. In Portugal, community prevalence data is very limited. The 10/66 Dementia Research...

    Authors: Manuel Gonçalves-Pereira, Ana Cardoso, Ana Verdelho, Joaquim Alves da Silva, Manuel Caldas de Almeida, Alexandra Fernandes, Cátia Raminhos, Cleusa P. Ferri, A. Matthew Prina, Martin Prince and Miguel Xavier

    Citation: BMC Geriatrics 2017 17:261

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  21. Content type: Research Article

    Previous studies reported mixed results regarding the association between cognition and body weight in late life. We evaluated the relationships between cognitive function and body composition among community-...

    Authors: Hye-Mi Noh, Sohee Oh, Hong Ji Song, Eun Young Lee, Jin-Young Jeong, Ohk-Hyun Ryu, Kyung-Soon Hong and Dong-Hyun Kim

    Citation: BMC Geriatrics 2017 17:259

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  22. Content type: Research Article

    The Doloplus-2 is a pain assessment scale for assessing pain in older adults with cognitive impairment. It is used in clinical practice and research. However, evidence for its measurement properties, feasibili...

    Authors: Hanne Marie Rostad, Inger Utne, Ellen Karine Grov, Martine Puts and Liv Halvorsrud

    Citation: BMC Geriatrics 2017 17:257

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  23. Content type: Research Article

    Type 2 Diabetes (T2D) is associated with increased risk of dementia. We aimed to determine the feasibility of a randomised controlled trial (RCT) examining the efficacy of exercise on cognition and brain struc...

    Authors: M. L. Callisaya, R. M. Daly, J. E. Sharman, D. Bruce, T. M. E. Davis, T. Greenaway, M. Nolan, R. Beare, M. G. Schultz, T. Phan, L. C. Blizzard and V. K. Srikanth

    Citation: BMC Geriatrics 2017 17:237

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  24. Content type: Research article

    Decreased circulating tryptophan (Trp) levels are frequently observed in elderly patients with neurodegenerative disease including Alzheimer’s disease. Trp may serve as a potential biomarker for monitoring dis...

    Authors: Yusuke Adachi, Yoshiki Shimodaira, Hidehiro Nakamura, Akira Imaizumi, Maiko Mori, Yoko Kageyama, Yasushi Noguchi, Asuka Seki, Yuki Okabe, Yuko Miyake, Kaori Ono and Shu Kumagai

    Citation: BMC Geriatrics 2017 17:239

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  25. Content type: Research Article

    Few studies have addressed the relationship between dementia and crime. We conducted a study of persons who got a primary or secondary diagnosis of dementia or cognitive disorder in a forensic psychiatric exam...

    Authors: Anette Ekström, Marianne Kristiansson and Karin Sparring Björkstén

    Citation: BMC Geriatrics 2017 17:219

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  26. Content type: Research Article

    Atrial fibrillation (AF) is often asymptomatic and undiagnosed until an ischaemic stroke occurs. An irregular pulse is a key manifestation of AF. We assessed whether pulse self-palpation is feasible in screeni...

    Authors: Jussi Jaakkola, Raine Virtanen, Tuija Vasankari, Marika Salminen and K.E. Juhani Airaksinen

    Citation: BMC Geriatrics 2017 17:218

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  27. Content type: Research Article

    The cerebrospinal fluid (CSF) biomarkers amyloid β (Aβ), phospho tau (P-tau) and total tau (T-tau) are used increasingly to support a clinical diagnosis of Alzheimer’s disease. The diagnostic power of these bi...

    Authors: Anne-Brita Knapskog, Rannveig Sakshaug Eldholm, Anne Braekhus, Knut Engedal and Ingvild Saltvedt

    Citation: BMC Geriatrics 2017 17:210

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  28. Content type: Research Article

    The Alzheimer’s disease (AD) brain displays atrophy with amyloid-β (Aβ) and tau deposition, whereas decreased Aβ42 and increased tau are measured in cerebrospinal fluid (CSF). The aim of this study was to rela...

    Authors: V. Velickaite, V. Giedraitis, K. Ström, I. Alafuzoff, H. Zetterberg, L. Lannfelt, L. Kilander, E-M. Larsson and M. Ingelsson

    Citation: BMC Geriatrics 2017 17:208

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  29. Content type: Research Article

    Behavioral and psychological symptoms of dementia (BPSD) are common and varied in the elderly. The aim of the current study was to explore associations between BPSD and dysphoric symptoms at different levels o...

    Authors: Agnes Lindbo, Maria Gustafsson, Ulf Isaksson, Per-Olof Sandman and Hugo Lövheim

    Citation: BMC Geriatrics 2017 17:206

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  30. Content type: Case report

    Elderly patients have a long list of differentials for causes of acute confusion and altered consciousness levels, including infectious agents. In addition, elderly, retired patients often have more time to tr...

    Authors: James Veater, Farhan Mehedi, Chee Kay Cheung, Laura Nabarro, Jane Osborne, Nicholas Wong, Martin Wiselka and Julian W Tang

    Citation: BMC Geriatrics 2017 17:193

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  31. Content type: Research Article

    New or increased impairments may develop several decades after an acute poliomyelitis infection. These new symptoms, commonly referred to as late effects of polio (LEoP), are characterised by muscular weakness...

    Authors: Catharina Sjödahl Hammarlund, Jan Lexell and Christina Brogårdh

    Citation: BMC Geriatrics 2017 17:179

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  32. Content type: Research Article

    Physical activity plays a pivotal role in the development of disability and may modify the negative effect of vascular risk factors on progression of both cardio and cerebrovascular disorders. The aim of this ...

    Authors: Anna F. Pettersson, Lars-Olof Wahlund, Lena Bronge, Elisabeth Olsson, Kaarina Amberla, Hansjoerg Baezner and Milita Crisby

    Citation: BMC Geriatrics 2017 17:142

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  33. Content type: Research Article

    Worldwide, the population is aging and the number of individuals diagnosed with dementia is rising rapidly. Currently, there are no effective pharmaceutical cures. Hence, identifying lifestyle approaches that ...

    Authors: Lisanne F. ten Brinke, Jennifer C. Davis, Cindy K. Barha and Teresa Liu-Ambrose

    Citation: BMC Geriatrics 2017 17:139

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  34. Content type: Research Article

    To determine the association between amyloid-beta (Aβ) plaque deposition and changes in global cognition, executive functions, information processing speed, and falls risk over a 12-month period in older adult...

    Authors: Elizabeth Dao, John R. Best, Ging-Yuek Robin Hsiung, Vesna Sossi, Claudia Jacova, Roger Tam and Teresa Liu-Ambrose

    Citation: BMC Geriatrics 2017 17:133

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  35. Content type: Research article

    Alzheimer’s disease (AD) is the most common cause of dementia and early and accurate diagnosis is important. Olfactory dysfunction is an early sign of AD. The contribution by test of olfactory function has bee...

    Authors: Ib Thrane Christensen, Elna-Marie Larsson, Ida E. Holm, Ole B.F. Nielsen and Stig Andersen

    Citation: BMC Geriatrics 2017 17:129

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  36. Content type: Research Article

    One of the most common uses of the Internet is to search for health-related information. Although scientific evidence pertaining to cognitive health promotion has expanded rapidly in recent years, it is unclea...

    Authors: P.V. Hunter, M. Delbaere, M. E. O’Connell, A. Cammer, J. X. Seaton, T. Friedrich and F. Fick

    Citation: BMC Geriatrics 2017 17:125

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  37. Content type: Study protocol

    Delirium is common, affecting at least 20% of older hospital inpatients. It is widely accepted that delirium is associated with dementia but the degree of causation within this relationship is unclear. Previou...

    Authors: Sarah J. Richardson, Daniel H.J. Davis, Blossom Stephan, Louise Robinson, Carol Brayne, Linda Barnes, Stuart Parker and Louise M. Allan

    Citation: BMC Geriatrics 2017 17:98

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  38. Content type: Study protocol

    To date there is no cure or an effective disease-modifying drug to treat dementia. Available acetylcholine-esterase inhibiting drugs or memantine only produce small benefits on cognitive and behavioural functi...

    Authors: E. G. A. Karssemeijer, W. J. R. Bossers, J. A. Aaronson, R. P. C. Kessels and M. G. M. Olde Rikkert

    Citation: BMC Geriatrics 2017 17:73

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  39. Content type: Research Article

    The prevalence of psychotropic drug (PTD) use in NH residents is high, but few have explored prevalence and persistency in PTD in NH residents and factors associated with persistency. This at the same time as ...

    Authors: Anne-Sofie Helvik, Jūratė Šaltytė Benth, Bei Wu, Knut Engedal and Geir Selbæk

    Citation: BMC Geriatrics 2017 17:52

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  40. Content type: Research Article

    Sunlight exposure and high vitamin D status have been hypothesised to reduce the risk of developing dementia. The objective of our research was to determine whether lack of sunlight and hypovitaminosis D over ...

    Authors: Isolde Sommer, Ursula Griebler, Christina Kien, Stefanie Auer, Irma Klerings, Renate Hammer, Peter Holzer and Gerald Gartlehner

    Citation: BMC Geriatrics 2017 17:16

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  41. Content type: Study protocol

    Frequent hospitalization and permanent nursing home placement not only affect the well-being of persons with dementia, but also place great financial strain on society. Therefore, it is important to create eff...

    Authors: Sophie Vandepitte, Nele Van Den Noortgate, Koen Putman, Sofie Verhaeghe and Lieven Annemans

    Citation: BMC Geriatrics 2016 16:207

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  42. Content type: Research Article

    Alzheimer’s disease (AD), the commonest cause of dementia, represents a significant cost to UK society. This analysis describes resource utilisation, costs and clinical outcomes in non-institutionalised patien...

    Authors: Alan Lenox-Smith, Catherine Reed, Jeremie Lebrec, Mark Belger and Roy W. Jones

    Citation: BMC Geriatrics 2016 16:195

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  43. Content type: Research Article

    Bilingualism may protect against cognitive aging and delay the onset of dementia. However, studies comparing monolinguals and bilinguals on such metrics have produced inconsistent results complicated by confou...

    Authors: Claudia Padilla, Mario F. Mendez, Elvira E. Jimenez and Edmond Teng

    Citation: BMC Geriatrics 2016 16:189

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  44. Content type: Research Article

    The discrepancy between the number of admissions and the allocation of hospital beds means that many patients admitted to hospital can be placed in units or wards other than that which specialise in the patien...

    Authors: Lua Perimal-Lewis, Clare Bradley, Paul H. Hakendorf, Craig Whitehead, Louise Heuzenroeder and Maria Crotty

    Citation: BMC Geriatrics 2016 16:190

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  45. Content type: Research Article

    Subjective cognitive decline (SCD), i.e., the self-perceived feeling of worsening cognitive function, may be the first notable syndrome of preclinical Alzheimer’s disease and other dementias. However, not all ...

    Authors: Susanne Roehr, Arno Villringer, Matthias C. Angermeyer, Tobias Luck and Steffi G. Riedel-Heller

    Citation: BMC Geriatrics 2016 16:180

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  46. Content type: Research article

    Few studies have investigated factors associated with depression among elderly people with and without stroke concurrently, using identical settings, procedures and study variables. The aim was to investigate ...

    Authors: Carl Hörnsten, Hugo Lövheim, Peter Nordström and Yngve Gustafson

    Citation: BMC Geriatrics 2016 16:174

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