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Neurology, stroke and cognition

Section edited by Pieter Jelle Visser

This section considers manuscripts on all neurological topics. Including: Alzheimer’s, cognition, stroke, dementia, wandering behaviours.

Page 1 of 3

  1. Content type: Study protocol

    The oldest-old (subjects aged 90 years and older) population represents the fastest growing segment of society and shows a high dementia prevalence rate of up to 40%. Only a few studies have investigated prote...

    Authors: Nienke Legdeur, Maryam Badissi, Stephen F. Carter, Sophie de Crom, Aleid van de Kreeke, Ralph Vreeswijk, Marijke C. Trappenburg, Mardien L. Oudega, Huiberdina L. Koek, Jos P. van Campen, Carolina J. P. W. Keijsers, Chinenye Amadi, Rainer Hinz, Mark F. Gordon, Gerald Novak, Jana Podhorna…

    Citation: BMC Geriatrics 2018 18:289

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  2. Content type: Research article

    Patients with delirium have increased risk of death, dementia and institutionalization, and prognosis differs between delirium motor subtypes. A few studies have identified associations between environmental f...

    Authors: Sigurd Evensen, Ingvild Saltvedt, Stian Lydersen, Torgeir Bruun Wyller, Kristin Taraldsen and Olav Sletvold

    Citation: BMC Geriatrics 2018 18:282

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  3. Content type: Study protocol

    One of the crucial challenges for the future of therapeutic approaches to Alzheimer’s disease (AD) is to target the main pathological processes responsible for disability and dependency. However, a progressive...

    Authors: Nawele Boublay, Denis Fédérico, Alain Pesce, Marc Verny, Frédéric Blanc, Marc Paccalin, Thomas Desmidt, Pierre Grosmaître, Olivier Moreaud, Solveig Relland, Estelle Bravant, Romain Bouet and Pierre Krolak-Salmon

    Citation: BMC Geriatrics 2018 18:280

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  4. Content type: Research article

    Dementia and physical morbidity are primary reasons for nursing home admission globally. However, data on physical morbidity in nursing home residents with and without dementia are scarce. The first aim of the...

    Authors: Live Bredholt Jørgensen, Berit Marie Thorleifsson, Geir Selbæk, Jūratė Šaltytė Benth and Anne-Sofie Helvik

    Citation: BMC Geriatrics 2018 18:254

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  5. Content type: Research article

    The objective of this study was to examine patient characteristics and health care resource utilization (HCRU) in the 36 months prior to a confirmatory diagnosis of Alzheimer’s disease (AD) compared to a match...

    Authors: Radhika Nair, Virginia S. Haynes, Mir Siadaty, Nick C. Patel, Adam S. Fleisher, Derek Van Amerongen, Michael M. Witte, AnnCatherine M. Downing, Leslie Ann Hazel Fernandez, Vishal Saundankar and Daniel E. Ball

    Citation: BMC Geriatrics 2018 18:243

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  6. Content type: Research Article

    The conventional scores of the neuropsychological batteries are not fully optimized for diagnosing dementia despite their variety and abundance of information. To achieve low-cost high-accuracy diagnose perfor...

    Authors: Hyun-Soo Choi, Jin Yeong Choe, Hanjoo Kim, Ji Won Han, Yeon Kyung Chi, Kayoung Kim, Jongwoo Hong, Taehyun Kim, Tae Hui Kim, Sungroh Yoon and Ki Woong Kim

    Citation: BMC Geriatrics 2018 18:234

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  7. Content type: Study protocol

    Delirium is a common and serious clinical syndrome which is often missed in routine clinical care. The core cognitive feature is inattention. We developed a novel bedside neuropsychological test for assessing ...

    Authors: Lisa-Marie Rutter, Eva Nouzova, David J. Stott, Christopher J. Weir, Valentina Assi, Jennifer H. Barnett, Caoimhe Clarke, Nikki Duncan, Jonathan Evans, Samantha Green, Kirsty Hendry, Meigan McGinlay, Jenny McKeever, Duncan G. Middleton, Stuart Parks, Robert Shaw…

    Citation: BMC Geriatrics 2018 18:217

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  8. Content type: Research Article

    Driving is related to social participation; therefore older drivers may be reluctant to cease driving. Continuation of driving has also been reported in a large proportion of patients with cognitive impairment...

    Authors: Dafne Piersma, Anselm B. M. Fuermaier, Dick De Waard, Ragnhild J. Davidse, Jolieke De Groot, Michelle J. A. Doumen, Rudolf W. H. M. Ponds, Peter P. De Deyn, Wiebo H. Brouwer and Oliver Tucha

    Citation: BMC Geriatrics 2018 18:216

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  9. Content type: Research article

    Individuals with mild cognitive impairment (MCI) are at heightened risk of developing dementia. Rapid advances in computing technology have enabled researchers to conduct cognitive training and rehabilitation ...

    Authors: Shaoqing Ge, Zheng Zhu, Bei Wu and Eleanor S. McConnell

    Citation: BMC Geriatrics 2018 18:213

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  10. Content type: Research article

    Cognition is a key factor in the regulation of normal walking and dual-task gait assessment is an accepted method to evaluate the relationship. The objective of this study was to create a framework for task co...

    Authors: Susan W. Hunter, Alison Divine, Courtney Frengopoulos and Manuel Montero Odasso

    Citation: BMC Geriatrics 2018 18:202

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  11. Content type: Research article

    An association between handgrip strength, hand dexterity and global cognition is suggested; however, it is unclear whether both hand motor functions are associated with executive function, which is important f...

    Authors: Kimi Estela Kobayashi-Cuya, Ryota Sakurai, Naoko Sakuma, Hiroyuki Suzuki, Masashi Yasunaga, Susumu Ogawa, Toru Takebayashi and Yoshinori Fujiwara

    Citation: BMC Geriatrics 2018 18:192

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    The Correction to this article has been published in BMC Geriatrics 2018 18:210

  12. Content type: Research article

    Risk factors for cognitive decline might depend on chronological age. The aim of the study was to explore the age dependency of risk factors for cognitive decline in cognitively healthy subjects aged 55–85 yea...

    Authors: N. Legdeur, M. W. Heymans, H. C. Comijs, M. Huisman, A. B. Maier and P. J. Visser

    Citation: BMC Geriatrics 2018 18:187

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  13. Content type: Research article

    The risk-benefit relationship of memantine treatment for Alzheimer’s disease (AD) remains unclear. In addition, variability between the results of clinical trials has been observed. The aim of this study was t...

    Authors: Lídia Blanco-Silvente, Dolors Capellà, Josep Garre-Olmo, Joan Vilalta-Franch and Xavier Castells

    Citation: BMC Geriatrics 2018 18:168

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  15. Content type: Study protocol

    Late-life cognitive decline, caused by progressive neuronal loss leading to brain atrophy years before symptoms are detected, is expected to double in Canada over the next two decades. Cognitive impairment in ...

    Authors: Sana Tariq, Christopher D. d’Esterre, Tolulope T. Sajobi, Eric E. Smith, Richard Stewart Longman, Richard Frayne, Shelagh B. Coutts, Nils D. Forkert and Philip A. Barber

    Citation: BMC Geriatrics 2018 18:163

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  16. Content type: Research article

    The Informant Questionnaire on Cognitive Decline in the Elderly (IQCODE) is widely used as a complementary screening tool for dementia. However, there are few studies concerning the efficacy of the IQCODE for ...

    Authors: Yunlong Ding, Jiali Niu, Yanrong Zhang, Wenpeng Liu, Yan Zhou, Can Wei and Yan Liu

    Citation: BMC Geriatrics 2018 18:146

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  17. Content type: Research article

    Alzheimer’s disease (AD) dementia, a progressive neurodegenerative disease, exerts significant burden upon patients, caregivers, and healthcare systems globally. The current study investigated the associations...

    Authors: William Montgomery, Amir Goren, Kristin Kahle-Wrobleski, Tomomi Nakamura and Kaname Ueda

    Citation: BMC Geriatrics 2018 18:141

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  18. Content type: Research article

    Community health professionals play a significant role in dementia care. However, little is known about community health professionals’ capacity in dementia care, especially in low and middle-income countries....

    Authors: Yao Wang, Lily Dongxia Xiao, Yang Luo, Shui-Yuan Xiao, Craig Whitehead and Owen Davies

    Citation: BMC Geriatrics 2018 18:122

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  19. Content type: Research article

    Vascular risk factors increase the risk of Alzheimer’s disease (AD), but there is limited evidence on whether comorbid vascular conditions and risk factors have an impact on disease progression. The aim of thi...

    Authors: Rannveig Sakshaug Eldholm, Karin Persson, Maria Lage Barca, Anne-Brita Knapskog, Lena Cavallin, Knut Engedal, Geir Selbaek, Eva Skovlund and Ingvild Saltvedt

    Citation: BMC Geriatrics 2018 18:120

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  20. Content type: Study protocol

    There are effective non-pharmacological treatment programs that reduce functional disability and changed behaviours in people with dementia. However, these programs (such as the Care of People with dementia in...

    Authors: Lindy Clemson, Kate Laver, Yun-Hee Jeon, Tracy A Comans, Justin Scanlan, Miia Rahja, Jennifer Culph, Lee-Fay Low, Sally Day, Monica Cations, Maria Crotty, Susan Kurrle, Catherine Piersol and Laura N. Gitlin

    Citation: BMC Geriatrics 2018 18:108

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  21. Content type: Research Article

    Self-rated health predicts health outcomes independently of levels of disability or mood. Little is known about what influences the subjective health experience of stroke survivors. Our aim was to investigate ...

    Authors: N. Mavaddat, E. Sadler, L. Lim, K. Williams, E. Warburton, A. L. Kinmonth, J. Mant, J. Burt and C. McKevitt

    Citation: BMC Geriatrics 2018 18:81

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  22. Content type: Research article

    Many older adults have low levels of health literacy which affects their ability to participate optimally in healthcare. It is unclear how cognitive decline contributes to health literacy. To study this, longi...

    Authors: Bas Geboers, Ellen Uiters, Sijmen A. Reijneveld, Carel J. M. Jansen, Josué Almansa, Astrid C. J. Nooyens, W. M. Monique Verschuren, Andrea F. de Winter and H. Susan J. Picavet

    Citation: BMC Geriatrics 2018 18:77

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  24. Content type: Research Article

    It has been suggested that tooth loss in later life might increase dementia incidence. The objective of this analysis is to systematically review the current evidence on the relationship between the number of ...

    Authors: Bumjo Oh, Dong-Hun Han, Kyu-Tae Han, Xibei Liu, Johnson Ukken, Carina Chang, Kiki Dounis and Ji Won Yoo

    Citation: BMC Geriatrics 2018 18:48

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  25. Content type: Research Article

    Elderly persons with a dementia diagnosis often suffer from different neuropsychiatric symptoms (NPS) such as delusions, hallucinations, depression, anxiety, irritability and agitation. Currently, the medical ...

    Authors: Iris Zahirovic, Gustav Torisson, Carina Wattmo and Elisabet Londos

    Citation: BMC Geriatrics 2018 18:50

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  26. Content type: Research article

    Cognitive impairment places older adults at high risk of functional disability in their daily-life activities, and thus affecting their quality of life. This study aimed to examine the effects of Tai Chi on ge...

    Authors: Mei-yi Siu and Diana T. F. Lee

    Citation: BMC Geriatrics 2018 18:37

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  27. Content type: Research Article

    Identifying how persons with dementia experience lived space is important for enabling supportive living environments and creating communities that compensate for the fading capabilities of these persons. Seve...

    Authors: Linn Hege Førsund, Ellen Karine Grov, Anne-Sofie Helvik, Lene Kristine Juvet, Kirsti Skovdahl and Siren Eriksen

    Citation: BMC Geriatrics 2018 18:33

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  28. Content type: Study protocol

    Given the world’s aging population, it is important to identify strategies that promote healthy cognitive aging and minimize cognitive decline. Currently, no curative pharmaceutical therapy exists for cognitiv...

    Authors: Lisanne F. ten Brinke, John R. Best, Rachel A. Crockett and Teresa Liu-Ambrose

    Citation: BMC Geriatrics 2018 18:31

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  29. Content type: Research article

    Delirium increases the risk of mortality during an acute hospital admission. Full syndromal delirium (FSD) is associated with greatest risk and subsyndromal delirium (SSD) is associated with intermediate risk,...

    Authors: R. A. Diwell, D.H. Davis, V. Vickerstaff and E. L. Sampson

    Citation: BMC Geriatrics 2018 18:24

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  30. Content type: Research article

    Medications are frequently reported as both predisposing factors and inducers of delirium. This review evaluated the available evidence and determined the magnitude of risk of postoperative delirium associated...

    Authors: Gizat M. Kassie, Tuan A. Nguyen, Lisa M. Kalisch Ellett, Nicole L. Pratt and Elizabeth E. Roughead

    Citation: BMC Geriatrics 2017 17:298

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  31. Content type: Research Article

    Several previous studies reported social participation may reduce the incident of dementia; therefore, the type of positions held in the organization may relate to dementia onset. However, this hypothesis rema...

    Authors: Yuta Nemoto, Tami Saito, Satoru Kanamori, Taishi Tsuji, Kokoro Shirai, Hiroyuki Kikuchi, Kazushi Maruo, Takashi Arao and Katsunori Kondo

    Citation: BMC Geriatrics 2017 17:297

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  32. Content type: Research Article

    Reduced level of arousal is commonly observed in medical admissions and may predict in-hospital mortality. Delirium and reduced level of arousal are closely related. We systematically reviewed and conducted a ...

    Authors: Amy Todd, Samantha Blackley, Jennifer K. Burton, David J. Stott, E. Wesley Ely, Zoë Tieges, Alasdair M. J. MacLullich and Susan D. Shenkin

    Citation: BMC Geriatrics 2017 17:283

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  33. Content type: Research Article

    Anxiety and depression are common in Parkinson disease and both are important determinants of quality of life in patients. Several risk factors are identified but few research have investigated general and Par...

    Authors: Shi-Shuang Cui, Juan-Juan Du, Rao Fu, Yi-Qi Lin, Pei Huang, Ya-Chao He, Chao Gao, Hua-Long Wang and Sheng-Di Chen

    Citation: BMC Geriatrics 2017 17:270

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  34. Content type: Research Article

    Dementia imposes a high burden of disease worldwide. Recent epidemiological studies in European community samples are scarce. In Portugal, community prevalence data is very limited. The 10/66 Dementia Research...

    Authors: Manuel Gonçalves-Pereira, Ana Cardoso, Ana Verdelho, Joaquim Alves da Silva, Manuel Caldas de Almeida, Alexandra Fernandes, Cátia Raminhos, Cleusa P. Ferri, A. Matthew Prina, Martin Prince and Miguel Xavier

    Citation: BMC Geriatrics 2017 17:261

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  35. Content type: Research Article

    Previous studies reported mixed results regarding the association between cognition and body weight in late life. We evaluated the relationships between cognitive function and body composition among community-...

    Authors: Hye-Mi Noh, Sohee Oh, Hong Ji Song, Eun Young Lee, Jin-Young Jeong, Ohk-Hyun Ryu, Kyung-Soon Hong and Dong-Hyun Kim

    Citation: BMC Geriatrics 2017 17:259

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  36. Content type: Research Article

    The Doloplus-2 is a pain assessment scale for assessing pain in older adults with cognitive impairment. It is used in clinical practice and research. However, evidence for its measurement properties, feasibili...

    Authors: Hanne Marie Rostad, Inger Utne, Ellen Karine Grov, Martine Puts and Liv Halvorsrud

    Citation: BMC Geriatrics 2017 17:257

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  37. Content type: Research Article

    Type 2 Diabetes (T2D) is associated with increased risk of dementia. We aimed to determine the feasibility of a randomised controlled trial (RCT) examining the efficacy of exercise on cognition and brain struc...

    Authors: M. L. Callisaya, R. M. Daly, J. E. Sharman, D. Bruce, T. M. E. Davis, T. Greenaway, M. Nolan, R. Beare, M. G. Schultz, T. Phan, L. C. Blizzard and V. K. Srikanth

    Citation: BMC Geriatrics 2017 17:237

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  38. Content type: Research article

    Decreased circulating tryptophan (Trp) levels are frequently observed in elderly patients with neurodegenerative disease including Alzheimer’s disease. Trp may serve as a potential biomarker for monitoring dis...

    Authors: Yusuke Adachi, Yoshiki Shimodaira, Hidehiro Nakamura, Akira Imaizumi, Maiko Mori, Yoko Kageyama, Yasushi Noguchi, Asuka Seki, Yuki Okabe, Yuko Miyake, Kaori Ono and Shu Kumagai

    Citation: BMC Geriatrics 2017 17:239

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  39. Content type: Research Article

    Few studies have addressed the relationship between dementia and crime. We conducted a study of persons who got a primary or secondary diagnosis of dementia or cognitive disorder in a forensic psychiatric exam...

    Authors: Anette Ekström, Marianne Kristiansson and Karin Sparring Björkstén

    Citation: BMC Geriatrics 2017 17:219

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  40. Content type: Research Article

    Atrial fibrillation (AF) is often asymptomatic and undiagnosed until an ischaemic stroke occurs. An irregular pulse is a key manifestation of AF. We assessed whether pulse self-palpation is feasible in screeni...

    Authors: Jussi Jaakkola, Raine Virtanen, Tuija Vasankari, Marika Salminen and K.E. Juhani Airaksinen

    Citation: BMC Geriatrics 2017 17:218

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  41. Content type: Research Article

    The cerebrospinal fluid (CSF) biomarkers amyloid β (Aβ), phospho tau (P-tau) and total tau (T-tau) are used increasingly to support a clinical diagnosis of Alzheimer’s disease. The diagnostic power of these bi...

    Authors: Anne-Brita Knapskog, Rannveig Sakshaug Eldholm, Anne Braekhus, Knut Engedal and Ingvild Saltvedt

    Citation: BMC Geriatrics 2017 17:210

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  42. Content type: Research Article

    The Alzheimer’s disease (AD) brain displays atrophy with amyloid-β (Aβ) and tau deposition, whereas decreased Aβ42 and increased tau are measured in cerebrospinal fluid (CSF). The aim of this study was to rela...

    Authors: V. Velickaite, V. Giedraitis, K. Ström, I. Alafuzoff, H. Zetterberg, L. Lannfelt, L. Kilander, E-M. Larsson and M. Ingelsson

    Citation: BMC Geriatrics 2017 17:208

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  43. Content type: Research Article

    Behavioral and psychological symptoms of dementia (BPSD) are common and varied in the elderly. The aim of the current study was to explore associations between BPSD and dysphoric symptoms at different levels o...

    Authors: Agnes Lindbo, Maria Gustafsson, Ulf Isaksson, Per-Olof Sandman and Hugo Lövheim

    Citation: BMC Geriatrics 2017 17:206

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  44. Content type: Case report

    Elderly patients have a long list of differentials for causes of acute confusion and altered consciousness levels, including infectious agents. In addition, elderly, retired patients often have more time to tr...

    Authors: James Veater, Farhan Mehedi, Chee Kay Cheung, Laura Nabarro, Jane Osborne, Nicholas Wong, Martin Wiselka and Julian W Tang

    Citation: BMC Geriatrics 2017 17:193

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  45. Content type: Research Article

    New or increased impairments may develop several decades after an acute poliomyelitis infection. These new symptoms, commonly referred to as late effects of polio (LEoP), are characterised by muscular weakness...

    Authors: Catharina Sjödahl Hammarlund, Jan Lexell and Christina Brogårdh

    Citation: BMC Geriatrics 2017 17:179

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  46. Content type: Research Article

    Physical activity plays a pivotal role in the development of disability and may modify the negative effect of vascular risk factors on progression of both cardio and cerebrovascular disorders. The aim of this ...

    Authors: Anna F. Pettersson, Lars-Olof Wahlund, Lena Bronge, Elisabeth Olsson, Kaarina Amberla, Hansjoerg Baezner and Milita Crisby

    Citation: BMC Geriatrics 2017 17:142

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  47. Content type: Research Article

    Worldwide, the population is aging and the number of individuals diagnosed with dementia is rising rapidly. Currently, there are no effective pharmaceutical cures. Hence, identifying lifestyle approaches that ...

    Authors: Lisanne F. ten Brinke, Jennifer C. Davis, Cindy K. Barha and Teresa Liu-Ambrose

    Citation: BMC Geriatrics 2017 17:139

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  48. Content type: Research Article

    To determine the association between amyloid-beta (Aβ) plaque deposition and changes in global cognition, executive functions, information processing speed, and falls risk over a 12-month period in older adult...

    Authors: Elizabeth Dao, John R. Best, Ging-Yuek Robin Hsiung, Vesna Sossi, Claudia Jacova, Roger Tam and Teresa Liu-Ambrose

    Citation: BMC Geriatrics 2017 17:133

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  49. Content type: Research article

    Alzheimer’s disease (AD) is the most common cause of dementia and early and accurate diagnosis is important. Olfactory dysfunction is an early sign of AD. The contribution by test of olfactory function has bee...

    Authors: Ib Thrane Christensen, Elna-Marie Larsson, Ida E. Holm, Ole B.F. Nielsen and Stig Andersen

    Citation: BMC Geriatrics 2017 17:129

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  50. Content type: Research Article

    One of the most common uses of the Internet is to search for health-related information. Although scientific evidence pertaining to cognitive health promotion has expanded rapidly in recent years, it is unclea...

    Authors: P.V. Hunter, M. Delbaere, M. E. O’Connell, A. Cammer, J. X. Seaton, T. Friedrich and F. Fick

    Citation: BMC Geriatrics 2017 17:125

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