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Biology and technology

Section edited by John Tower

This section considers all manuscripts on biomarkers, biological mechanisms, diagnostic instruments, use of technology in geriatric settings, biology of ageing, genetics.

  1. Research participation burden, despite being an integral concept in research ethics, is not well-conceptualized in the context of the use of technology in research. This knowledge gap is especially critical fo...

    Authors: Katarzyna Kabacińska, Nicole Sharma, Jeffrey Kaye, Nora Mattek, Boris Kuzeljevic and Julie M. Robillard

    Citation: BMC Geriatrics 2020 20:50

    Content type: Research article

    Published on:

  2. Delayed diagnosis of bloodstream infection (BSI) occurs in > 20% of older patients, with misdiagnosis in 35%. Our objective was to develop and validate a clinically useful screening tool to identify older pati...

    Authors: Sandra A. N. Walker, Heather Bannerman, Nathan Ma, Christine Peragine, Marion Elligsen, Lesley Palmay, Evelyn Williams and Barbara Liu

    Citation: BMC Geriatrics 2020 20:6

    Content type: Research article

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  3. Telomeres are non-coding sequences at the end of eukaryote chromosomes, which in complex with associated proteins serve to protect subtelomeric DNA. Telomeres shorten with each cell division, are regarded as a...

    Authors: Are A. Kalstad, Sjur Tveit, Peder L. Myhre, Kristian Laake, Trine B. Opstad, Arnljot Tveit, Erik B. Schmidt, Svein Solheim, Harald Arnesen and Ingebjørg Seljeflot

    Citation: BMC Geriatrics 2019 19:376

    Content type: Research article

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  5. This study assessed the safety and efficacy of deep tissue laser therapy on the management of pain, functionality, systemic inflammation, and overall quality of life of older adults with painful diabetic perip...

    Authors: Prasun Chatterjee, Achal K. Srivastava, Deepa A. Kumar, Avinash Chakrawarty, Maroof A. Khan, Akash K. Ambashtha, Vijay Kumar, Luis De Taboada and Aparajit B. Dey

    Citation: BMC Geriatrics 2019 19:218

    Content type: Research article

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  6. Use of monitoring technologies (e.g. wearable or environmental sensors) in long-term care generates extensive ethical debate, primarily about their potential to enhance resident safety weighed against concerns...

    Authors: Alex Hall, Christine Brown Wilson, Emma Stanmore and Chris Todd

    Citation: BMC Geriatrics 2019 19:145

    Content type: Research article

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  7. Atrial fibrillation (AF) is the most common arrhythmia and has increased prevalence in older patients, leading to poor prognosis for these patients. There is a need for a biomarker or a model of prognostic eva...

    Authors: Shihui Fu, Jie Jiao, Yi Guo, Bing Zhu and Leiming Luo

    Citation: BMC Geriatrics 2019 19:56

    Content type: Research article

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  8. The aim of this trial is to evaluate the effect of SENATOR software on incident, adverse drug reactions (ADRs) in older, multimorbid, hospitalized patients. The SENATOR software produces a report designed to o...

    Authors: Amanda H. Lavan, Denis O’Mahony, Paul Gallagher, Richard Fordham, Evelyn Flanagan, Darren Dahly, Stephen Byrne, Mirko Petrovic, Adalsteinn Gudmundsson, Olafur Samuelsson, Antonio Cherubini, Alfonso J. Cruz-Jentoft, Roy L. Soiza and Joseph A. Eustace

    Citation: BMC Geriatrics 2019 19:40

    Content type: Study protocol

    Published on:

  9. As the most common cholangiocarcinoma, hilar cholangiocarcinoma (HCCA) is a challenge in hepatobiliary surgery and causes a very poor prognosis. This study was designed to explore whether 18F-fluorodeoxyglucose p...

    Authors: Xuling Li, Ying Zhang and Yongyang Zhang

    Citation: BMC Geriatrics 2018 18:150

    Content type: Research article

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  10. The question of an age dependence of individual radiosensitivity has only marginally been studied so far. Therefore, we analyzed blood samples of healthy individuals and cancer patients of different ages to de...

    Authors: Barbara Schuster, Anna Ellmann, Theresa Mayo, Judith Auer, Matthias Haas, Markus Hecht, Rainer Fietkau and Luitpold V. Distel

    Citation: BMC Geriatrics 2018 18:105

    Content type: Research Article

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  11. SuPAR is a biomarker that reflects the level of immune activation. As inflammation plays an important role in the ageing process of the cardiovascular system, we hypothesized that suPAR might be a useful predi...

    Authors: Angela S. Koh, Bhaarathy Velmurugan, Fei Gao, Ru San Tan, Jia-Ing Wong, Louis L. Y. Teo, Bryan M. H. Keng, Serene J. M. Chua, Jian-Min Yuan, Woon-Puay Koh and Christine Cheung

    Citation: BMC Geriatrics 2017 17:275

    Content type: Research Article

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  12. Older people have the highest incidence of acute medical admissions. Old age and acute hospital admissions are associated with a high risk of adverse health outcomes after discharge, such as reduced physical p...

    Authors: Henrik Hedegaard Klausen, Janne Petersen, Thomas Bandholm, Helle Gybel Juul-Larsen, Juliette Tavenier, Jesper Eugen-Olsen and Ove Andersen

    Citation: BMC Geriatrics 2017 17:62

    Content type: Research Article

    Published on:

    The Erratum to this article has been published in BMC Geriatrics 2017 17:67

  13. Given the unreliable self-report in patients with dementia, pain assessment should also rely on the observation of pain behaviors, such as facial expressions. Ideal observers should be well trained and should ...

    Authors: Miriam Kunz, Dominik Seuss, Teena Hassan, Jens U. Garbas, Michael Siebers, Ute Schmid, Michael Schöberl and Stefan Lautenbacher

    Citation: BMC Geriatrics 2017 17:33

    Content type: Commentary

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  14. Brain-derived neurotrophic factor (BDNF) has been implicated in cognitive performance and the modulation of several metabolic parameters in some disease models, but its potential roles in successful aging rema...

    Authors: Jun-Hua Peng, Cheng-Wu Liu, Shang-Ling Pan, Hua-Yu Wu, Qing-Hua Liang, Rui-Jing Gan, Ling Huang, Yi Ding, Zhang-Ya Bian, Hao Huang, Ze-Ping Lv, Xiao-Ling Zhou and Rui-Xing Yin

    Citation: BMC Geriatrics 2017 17:4

    Content type: Research Article

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  15. Strong evidence implicates inflammation in the development of atherosclerotic heart disease but less is known about peripheral arterial disease (PAD). Our objective was to test the hypothesis that a composite ...

    Authors: Jane A. Cauley, Ahmed M. Kassem, Nancy E. Lane and Sara Thorson

    Citation: BMC Geriatrics 2016 16:213

    Content type: Research article

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  16. In mammals, the IGF-1 pathway affects the phenotype of aging. Since the function of the immune system is modulated by IGF-1, it is plausible that immunosenescence might in part result from altered control by t...

    Authors: Monika Budzinska, Magdalena Owczarz, Eliza Pawlik-Pachucka, Malgorzata Roszkowska-Gancarz, Przemyslaw Slusarczyk and Monika Puzianowska-Kuznicka

    Citation: BMC Geriatrics 2016 16:200

    Content type: Research Article

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  17. Presbycusis has a direct influence on autonomy of the elderly but hearing aids lack of affordability. Moreover a recent review demonstrate that electroacoustic characteristics of OTC hearing aids were generall...

    Authors: Guillaume Sacco, Sébastien Gonfrier, Bernard Teboul, Ivan Gahide, Fredéric Prate, Mathilde Demory-Zory, Jean-Michel Turpin, Claire Vuagnoux, Philippe Genovese, Stéphane Schneider, Olivier Guérin and Nicolas Guevara

    Citation: BMC Geriatrics 2016 16:136

    Content type: Research article

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  18. The Long Life Family Study (LLFS) is an international study to identify the genetic components of various healthy aging phenotypes. We hypothesized that pedigree-specific rare variants at longevity-associated ...

    Authors: Todd E. Druley, Lihua Wang, Shiow J. Lin, Joseph H. Lee, Qunyuan Zhang, E. Warwick Daw, Haley J. Abel, Sara E. Chasnoff, Enrique I. Ramos, Benjamin T. Levinson, Bharat Thyagarajan, Anne B. Newman, Kaare Christensen, Richard Mayeux and Michael A. Province

    Citation: BMC Geriatrics 2016 16:80

    Content type: Research article

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  20. Serum procalcitonin and high-sensitivity C-reactive protein (hs-CRP) elevations have been associated with pneumonia in adults. Our aim was to establish their diagnostic usefulness in a cohort of hospitalized m...

    Authors: Antonio Nouvenne, Andrea Ticinesi, Giuseppina Folesani, Nicoletta Cerundolo, Beatrice Prati, Ilaria Morelli, Loredana Guida, Fulvio Lauretani, Marcello Maggio, Rosalia Aloe, Giuseppe Lippi and Tiziana Meschi

    Citation: BMC Geriatrics 2016 16:16

    Content type: Research article

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  21. Metabolic syndrome’s (MetS) role in predicting cardiovascular diseases and diabetes has been confirmed in many large cohort studies. Nontraditionally, hematogram components are significantly related to MetS in...

    Authors: Peng-Fei Li, Jin-Shuen Chen, Jin-Biou Chang, Hsiao-Wen Chang, Chung-Ze Wu, Tsung-Ju Chuang, Chia-Luen Huang, Dee Pei, Chang-Hsun Hsieh and Yen-Lin Chen

    Citation: BMC Geriatrics 2016 16:10

    Content type: Research article

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  22. Problems with memory and decline in cognitive abilities are common during development of dementia. Different kinds of technologies may be useful in supporting persons with dementia and their relatives in daily...

    Authors: Annakarin Olsson, Kirsti Skovdahl and Maria Engström

    Citation: BMC Geriatrics 2016 16:3

    Content type: Research article

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  23. There is a functional decline of endothelial- dependent vasodilatation in the aging process. The aims of this study were to investigate if various microcirculatory parameters could correlate to anthropometrica...

    Authors: Daniel Alexandre Bottino, Flávia Gomes Lopes, Francisco José de Oliveira, Anete de Souza Mecenas, Ruth Clapauch and Eliete Bouskela

    Citation: BMC Geriatrics 2015 15:41

    Content type: Research article

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  24. Hearing loss is the third most prevalent chronic condition faced by older adults and has been linked to difficulties in speech perception, activities of daily living, and social interaction. Recent studies hav...

    Authors: Gina Miller, Craig Miller, Nicole Marrone, Carol Howe, Mindy Fain and Abraham Jacob

    Citation: BMC Geriatrics 2015 15:16

    Content type: Research article

    Published on:

  25. Up to half the residents of nursing homes for the elderly have asymptomatic bacteriuria (ABU), which should not be treated with antibiotics. A complementary test to discriminate between symptomatic urinary tra...

    Authors: Pär-Daniel Sundvall, Marie Elm, Peter Ulleryd, Sigvard Mölstad, Nils Rodhe, Lars Jonsson, Bengt Andersson, Mirjana Hahn-Zoric and Ronny Gunnarsson

    Citation: BMC Geriatrics 2014 14:88

    Content type: Research article

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  26. An association between cognition and physical function has been shown to exist but the roles of muscle and brain structure in this relationship are not fully understood. A greater understanding of these relati...

    Authors: Alixe HM Kilgour, Oliver M Todd and John M Starr

    Citation: BMC Geriatrics 2014 14:85

    Content type: Research article

    Published on:

  28. Given the increasing incidence of bacteraemia causing significant morbidity and mortality in older patients, this study aimed to compare the clinical features, laboratory findings and mortality of patients ove...

    Authors: Jessica Emily Green, Yohanes Ariathianto, Si Mun Wong, Craig Aboltins and Kwang Lim

    Citation: BMC Geriatrics 2014 14:55

    Content type: Research article

    Published on:

  29. To describe T-cell and natural killer (NK) cell phenotypes within nursing home elderly.

    Authors: Jennie Johnstone, Jamie Millar, Alina Lelic, Chris P Verschoor, Stephen D Walter, Philip J Devereaux, Jonathan Bramson and Mark Loeb

    Citation: BMC Geriatrics 2014 14:50

    Content type: Research article

    Published on:

  30. Promyelocytic leukemia nuclear bodies (PML-NBs) have been depicted as structures which are involved in processing cell damages and DNA double-strand break repairs. The study was designed to evaluate difference...

    Authors: Barbara Wenger, Manuela Schwegler, Maria Brunner, Christoph Daniel, Manfred Schmidt, Rainer Fietkau and Luitpold V Distel

    Citation: BMC Geriatrics 2014 14:42

    Content type: Research article

    Published on:

  32. Body composition changes with ageing can influence the adiponectin concentration. However, the component of body composition that is associated with adiponectin concentrations in older adults remains unclear.

    Authors: Hong Ji Song, Sohee Oh, Shanai Quan, Ohk-Hyun Ryu, Jin-Young Jeong, Kyung-Soon Hong and Dong-Hyun Kim

    Citation: BMC Geriatrics 2014 14:8

    Content type: Research article

    Published on:

  33. Recently, a direct correlation with telomere length, proliferative potential and telomerase activity has been found in the process of aging in peripheral blood cells. The objective of the study was to evaluate...

    Authors: Blanca Murillo-Ortiz, Froylán Albarrán-Tamayo, Sergio López-Briones, Sandra Martínez-Garza, Luis Benítez-Bribiesca and Diego Arenas-Aranda

    Citation: BMC Geriatrics 2013 13:99

    Content type: Research article

    Published on:

  34. Our previously proposed morphological classification of orthostatic hypotension (MOH) is an approach to the definition of three typical orthostatic hemodynamic patterns using non-invasive beat-to-beat monitoring....

    Authors: Roman Romero-Ortuno, Matthew DL O’Connell, Ciaran Finucane, Christopher Soraghan, Chie Wei Fan and Rose Anne Kenny

    Citation: BMC Geriatrics 2013 13:73

    Content type: Research article

    Published on:

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