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Table 1 Demographic Features of Study Population and SwalQoL Scores According to Cognitive Status

From: Dysphagia is closely related to frailty in mild-to-moderate Alzheimer’s disease

  

Cognitively Intact

n = 35

Mild AD

n = 36

Moderate AD

n = 30

P

 

Age, years

73.88 ± 6.76

75.58 ± 5.53

80.60 ± 7.99

< 0.001

 

Sex, Female

18 (51.4)

23(63.9)

18.0(60.0)

0.56

 

Education, ≤ 5 years

17(50.0)a

27(75.0)

26(86.7)

0.004

Multimorbidities

Diabetes Mellitus

18(51.4)

13(36.1)

7(23.3)

0.064

Hypertension

27(77.1)

26(72.2)

22(73.3)

0.88

Hyperlipidemia

12(34.3)

10(27.8)

7(23.3)

0.62

Coronary Artery Disease

11 (31.4)

11(30.6)

10(33.3)

0.97

Hypothyroidism

13(37.1)a

2(5.6)

2(5.6)

< 0.001

Malignancy

6(17.1)

7(19.4)

2(6.7)

0.31

Comprehensive Geriatric Assessment

Patients Living with Frailty,CFS

5(14.3)a

15(41.7)

28(93.3)

< 0.001

Patients Living with Frailty,FRAIL

11(32.4)

15(44.1)

26(86.7)a

< 0.001

Basic ADL

6.0[1.0]

6.0[1.0]

3.0[3.0]

< 0.001

IADL

8.0[0.0]

6.0[3.0]

1.0[2.0]

< 0.001

MMSE

28[5.25]

24[8.0]

17.0[9.0]

< 0.001

Yesavage GDS

3.0[7.0]

3.0[3.0]

5.0[5.0]

0.016

Depression Risk (GDS ≥ 5)

13(37.1)

9(25.0)

6(20.0)

0.28

Polypharmacy

24(68.6)

28(77.8)

23(76.7)

0.63

Malnutrition

Risk of Malnutrition

3(8.6)

10(28.6) a

6(18.2)

19(57.6)

8(27.6)

16(55.2)

0.001

Incontinence

9(25.7) a

19(57.8)

23(76.7)

< 0.001

Falls

3(8.6)a

12(35.3)

12(40.0)

0.008

Low Gait Speed (≤ 0.8 m/sec)*

21(60.0)

25(69.4)

27(90.0)a

0.024

 

EAT-10(≥ 3)*

14(40.0)

23(63.9)a

27(90)a

< 0.001

SWALQoL QUESTIONNAIRE

Burden

100.0[0.0]

100.0[12.5]

87.50[28.13]

0.005

Duration

100.0[12.5]

100.0[34.8]

75.0[56.25]

0.003

Desire

100.0[16.7]

100.0[31.22]

79.15[35.38]

0.001

Frequency

98.2[3.6]

94.60[12.03]

84.80[17.88]

< 0.001

Food Selection

100.0[25.0]

100.0[37.5]

62.50[65.63]

< 0.001

Communication

100.0[0.0]

100.0[0.0]

100.0[25.0]

0.029

Fear

100.0[0.0]

100.0[4.69]

100.0[29.69]

0.20

Mental Health

100.0[0.0]

100.0[3.75]

100.0[16.25]

0.015

Social

100.0[0.0]

100.0[11.25]

90.0[28.75]

< 0.001

Fatigue

75.0[50.0]

50.0[47.90]

41.65[50.0]

0.008

Sleep

50.0[75.0]

64.5[75.0]

68.75[65.63]

0.94

Total Score

88.73[12.28]

84.79[17.61]

77.72[15.72]

< 0.001

  1. Variables are presented as n (%), Median[IQR] or mean ± SD
  2. CFS: Clinical frailty scale, FRAIL: Fatigue, Resistance, Ambulation, Illness, Loss of weight, ADL: activities of daily living, IADL: instrumental activities of daily living, MMSE: Mini-mental state examination, GDS: geriatric depression scale, EAT-10: eating-assessment tool-10
  3. a According to subgroup analysis and after Bonferroni correction, the group of the difference was aroused from