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Table 2 Disease categories of 1446 included RCTs in 2019

From: Temporal changes in characteristics and external validity of randomized controlled trials in older people from 2012 to 2019

 

All included trials

(N = 1446)

Trials specifically designed for older people

(N = 116)

Trials not specifically designed for older people

(N = 1330)

Infectious

59 (4.1%)

2 (1.7%)

54 (4.3%)

Neoplasms

142 (9.8%)

10 (8.6%)

132 (9.9%)

Blood

18 (1.2%)

1 (0.9%)

17 (1.3%)

Metabolic

135 (9.3%)

5 (4.3%)

130 (9.8%)

Mental/behavioral

112 (7.7%)

14 (12.1%)

98 (7.4%)

Nervous system

78 (5.4%)

3 (2.6%)

75 (5.6%0

Eye

24 (1.7%)

3 (2.6%)

21 (1.6%)

Ear

3 (0.2%)

0 (0%)

3 (0.2%)

Circulatory

121 (8.4%)

18 (15.5%)

103 (7.7%)

Respiratory

57 (3.9%)

3 (2.6%)

54 (4.1%)

Digestive

63 (4.4%)

4 (3.4%)

59 (4.4%)

Skin

33 (2.3%)

2 (1.7%)

31 (2.3%)

Musculoskeletal

155 (10.7%)

22 (19.0%)

133 (10.0%)

Genitourinary

88 (6.1%)

6 (5.2%)

82 (6.2%)

Pregnancy

46 (3.2%)

0 (0%)

46 (3.5%)

Perinatal

34 (2.4%)

0 (0%)

34 (2.6%)

Congenital

9 (0.6%)

0 (0%)

9 (0.7%)

Symptoms

8 0.6%)

0 (0%)

8 (0.6%)

Injury

6 (0.4%)

0 (0%)

6 (0.5%)

External

10 (0.7%)

0 (0%)

10 (0.8%)

Contact with health services

18 (1.2%)

2 (1.7%)

16 (1.2%)

Other

227 (15.7%)

21 (18.1%)

206 (15.5%)

  1. Pearson’s Chi square test: p = 0.01
  2. Trials were classified as specifically designed for older people if minimum trial participant age ≥ 55 years, or if mean trial participant age ≥ 70 years
  3. Percentages are reported
  4. Abbreviations: RCT Randomized controlled trial