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Table 2 Comparison of cerebrospinal fluid related indicators

From: Preoperative cerebrospinal fluid biomarkers may be associated with postoperative delirium in patients undergoing knee/hip arthroplasty: the PNDABLE study

 

Non-POD

(n = 92)

POD

(n = 92)

P

CSF Aβ40

(100pg/mL)

56.60(35.82–80.90)

51.77(35.41–73.96)

0.400

CSF Aβ42

(pg/mL)

322.4(219.3-454.2)

154.6(114.4-207.8)

< 0.001

CSF t-Tau

(pg/mL)

158.6(114.5-203.6)

188.3(127.1-238.7)

0.037

CSF p-Tau

(pg/mL)

36.40(27.57–50.29)

39.70(28.79–48.96)

0.690

CSF PGRN

(100pg/mL)

27.16(16.70-36.31)

17.54(15.95–26.22)

0.001

CSF sTREM2

(ng/mL)

24.10 ± 12.43

23.11 ± 5.06

0.113

CSF α-syn

(100pg/mL)

15.14(8.75–18.43)

17.50(12.91–22.38)

0.001

CSF Aβ40/ t-Tau

34.18(24.52–48.12)

25.88(17.17–32.27)

0.951

CSF Aβ40/ p-Tau

143.4(99.42–187.2)

103.6(79.0-148.8)

0.175

CSF Aβ42/ t-Tau

1.94(1.34–3.16)

0.90(0.65–1.18)

< 0.001

CSF Aβ42/ p-Tau

8.43(5.20–12.30)

4.37(3.43–5.53)

< 0.001

  1. Notes: Table 2 shows that there were significant differences (P < 0.05) between the POD non-POD groups in CSF Aβ42, t-Tau, PGRN, α-syn, Aβ42/ t-Tau and Aβ42/p-Tau, which were included into univariable logistic regression
  2. Abbreviations: POD, postoperative delirium; CSF, Cerebrospinal Fluid; Aβ40, amyloid beta40; Aβ42, amyloid beta42; t-Tau, total Tau; p-Tau, phosphorylated Tau; PGRN, progranulin; sTREM2, soluble triggering receptor expressed on myeloid cells 2; α-syn, α-synuclein
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BMC Geriatrics

ISSN: 1471-2318

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