Association of laxatives use with incident dementia and modifying effect of genetic susceptibility: a population-based cohort study with propensity score matching

Table 2 Propensity score matched (PSM) association of laxative types with incidence of dementia

Laxative types	Users	Non-laxatives users	Dementia		Alzheimer’s disease		Vascular dementia
Laxative types	Users	Non-laxatives users	HR (95% CI) ^a	P value	HR (95% CI)	P value	HR (95% CI) ^a	P value
Bulk forming laxatives	289	1.00 (ref.)	1.16 (0.64–2.10)	0.621	1.30 (0.54–3.14)	0.565	1.94 (0.80–4.72)	0.143
Softeners and emollients	322	1.00 (ref.)	1.96 (1.23–3.12)	0.005	1.97 (0.93–4.16)	0.077	1.10 (0.35–3.45)	0.867
Stimulant laxatives	1220	1.00 (ref.)	1.80 (1.37–2.37)	< 0.001	1.12 (0.66–1.92)	0.673	1.16 (0.61–2.19)	0.649
Osmotic laxatives	549	1.00 (ref.)	2.07 (1.47–2.92)	< 0.001	1.63 (0.89–2.98)	0.110	2.34 (1.28–4.31)	0.006

^a Models were adjusted for sex, age, ethnicity, socioeconomic status, education attainment, current employment status, smoking status, alcohol consumption, physical activity, diet, BMI, heart disease, stroke, diabetes, hypertension, depression, cholesterol levels, constipation, and genetic risk. CI Confidence interval, HR Hazard ratio

ISSN: 1471-2318