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Fig. 2 | BMC Geriatrics

Fig. 2

From: Association of laxatives use with incident dementia and modifying effect of genetic susceptibility: a population-based cohort study with propensity score matching

Fig. 2

Hazards ratios (HRs) and 95% confidence interval (CIs) of dementia by joint exposures of laxatives use and genetic predisposition. a propensity-score match models were adjusted for sex, age, ethnicity, socioeconomic status, education attainment, current employment status, smoking status, alcohol consumption, physical activity, diet, BMI, heart disease, stroke, diabetes, hypertension, depression, constipation, and cholesterol levels. CI, confidence interval; HR, hazard ratio. Measures of additive interaction for dementia: Relative excess risk due to interaction (RERI): 0.736, 95% CI: 0.127, 1.346; Attributable proportion due to interaction (AP): 0.180, 95% CI: 0.047, 0.312; Synergy index (SI): 1.312, 95% CI: 1.050, 1.639. Measures of additive interaction for Alzheimer’s disease: Relative excess risk due to interaction (RERI):0.636, 95% CI: − 0.447, 1.719; Attributable proportion due to interaction (AP): 0.136, 95% CI: − 0.077, 0.348; Synergy index (SI): 1.209, 95% CI: 0.878, 1.666. Measures of additive interaction for vascular dementia: Relative excess risk due to interaction (RERI):0.683, 95% CI: − 0.340, 1.707; Attributable proportion due to interaction (AP): 0.203, 95% CI: − 0.065, 0.470; Synergy index (SI): 1.404, 95% CI: 0.843, 2.338

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