Clinical prediction rule for identifying older patients with toxigenic clostridioides difficile at the time of hospital admission

Table 3 Area under the ROC curve and probability of toxigenic Clostridioides difficile carriage at hospital admission based on a cut-off value in the derivation population, with cross-validation, and in the validation cohort

Variable	AUC ± SE	95% CI	Cut-off value	Sensitivity	95% CI	Specificity	95% CI	PPV	95% CI	NPV	95% CI
Training dataset	0.80 ± 0.031	0.74–0.86	0.45	75.25	65.7–83.3	74.3	64.6–82.4	74.5	67.3–80.6	75.0	67.7–81.1
Cross-validation (training dataset)	0.76 ± 0.035	0.70–0.82	0.47	75.25	65.7–83.3	74.3	64.6–82.4	74.5	67.3–80.6	75.0	67.7–81.1
Test dataset	0.84 ± 0.035	0.78–0.90	0.45	78.26	56.3–92.5	70.8	62.7–78.0	29.5	23.1–36.8	95.4	90.5–97.8

AUC, area under the receiver operating characteristic curve; CI, confidence interval; NPV, negative predictive value; PPV, positive predictive value; SE, standard error

ISSN: 1471-2318