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Table 1 Univariate analysis of relationship between all-cause mortality and clinical characteristics

From: Prognostic significance of frailty status in patients with primary lung cancer

Character

HR (95% CI for HR)

p.value

agea

0.99(0.99,1.00)

0.054

gender

 female

  

 male

1.073(0.943,1.22)

0.284

BMIb

 I

  

 II

0.9941(0.816,1.211)

0.953

 III

0.9805(0.783,1.227)

0.863

 IV

0.9920(0.795,1.237)

0.943

Frailtyc

 Robust

  

 Pre-frail

1.365(1.183,1.575)

 < 0.001

 Frail

1.616(1.349,1.936)

 < 0.001

TNM staged

 I

  

 II

1.262(0.893,1.782)

0.187

 III

2.516(1.875,3.378)

 < 0.001

 IV

4.871(3.707,6.400)

 < 0.001

Cancer histologye

  

 Adenocarcinoma

  

 Small cell

0.957(0.785,1.167)

0.666

 Squamous cell

1.017(0.853,1.213)

0.852

 Others

0.956(0.822,1.111)

0.557

Smoking historyf

 I

  

 II

1.0492 0.9531 0.9076 1.213

0.516

 III

0.8237 1.2140 0.6177 1.098

0.187

 IV

1.1245 0.8893 0.8665 1.459

0.378

CCIg

  

  < 3

  

  >  = 3

5.751(4.741,6.975)

 < 0.001

Surgery history

 no

  

 yes

0.367(0.317,0.425)

 < 0.001

Chemotherapy

 no

  

 yes

2.42(1.973,2.969)

 < 0.001

Radiotherapy

 no

  

 yes

1.018(0.841,1.233)

0.853

Target therapy

 no

  

 yes

1.016(0.859,1.2)

0.855

  1. Abbreviations: TNM, tumor, node and metastasis; BMI, Body Mass Index; CCI, Charlson comorbidity index;
  2. aAge: median(25%,75%); bBMI: Body mass index is calculated as weight in kilograms divided by height in meters squared, I: BMI < 18.5; II: 18.5 ≤ BMI < 23; III: 23 ≤ BMI < 26; IV: BMI ≥ 26; cFrailty: Robust, FI-LAB < 0.2; prefrail, FI-LAB 0.2–0.35; frail, FI-LAB > 0.35; dTNM stage: tumor, node and metastasis classification; eCancer histology: Tumor pathological staging is specifically divided into adenocarcinoma, squamous carcinoma, small cell lung cancer and other types of lung cancer; fSmoking history: I: non-smoking (< 100 cigarettes in life-time); II: present smoking(> 10 years of smoking and > 10 cigarettes per day); III: Occasional smoking (< 10 cigarettes per month); IV: past smoking(> 10 years of smoking and > 10 cigarettes per day), has quit smoking over six months; gCCI: Quantifies comorbidities based on the number and severity of diseases a patient has, and can be used to predict the risk of death from diseases