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Table 4 Univariate and Multivariate logistic regression for high PAA among PLWH participants

From: Association of Phenotypic Aging Marker with comorbidities, frailty and inflammatory markers in people living with HIV

PLWH participants

Univariate

Multivariate 1

Multivariate 2

OR

95% CI

p-value

aOR

95% CI

p-value

aOR

95% CI

p-value

Male

2.00

1.28, 3.14

0.002

1.26

0.72, 2.22

0.42

1.36

0.78, 2.37

0.28

BMI ≥ 25 kg/m2

(vs. < 25 kg/m2)

1.48

0.90, 2.42

0.119

1.07

0.58, 1.98

0.82

1.07

0.58, 1.97

0.84

Abnormal waist circumference

1.17

0.76, 1.81

0.48

Smoking

 Never/ ex-smoker

Ref

 current

2.57

1.29, 5.09

0.007

3.04

1.18, 7.81

0.021

2.70

1.09, 6.65

0.031

Alcohol drinking

 Never/ ex-smoker

Ref

 current

1.96

0.89, 4.33

0.096

1.61

0.54, 4.78

0.39

1.70

0.58, 4.94

0.33

Diabetes mellitus

4.08

2.06, 8.07

< 0.001

2.88

1.28, 6.51

0.011

2.84

1.26, 6.41

0.012

Hypertension

1.89

1.21, 2.94

0.005

1.36

0.79, 2.35

0.27

1.43

0.83, 2.47

0.20

Statin use

1.50

0.94, 2.38

0.086

1.24

0.7, 2.17

0.46

0.48

0.70, 2.15

0.48

HDL-cholesterol

≤40 mg/dL (vs. > 40 mg/dL)

1.24

0.78, 1.98

0.355

LDL-cholesterol

≥130 mg/dL (vs. < 130 mg/dL)

0.90

0.58, 1.41

0.656

Triglycerides

≥150 mg/dL (vs. < 150 mg/dL)

1.30

0.85, 2.01

0.228

ALT > 50

1.09

0.61, 1.95

0.778

Insulin, IU/mL (per unit increase)

1.05

1.02, 1.08

0.004

IL-6, pg/ml (per unit increase)

1.12

1.06, 1.18

< 0.001

1.11

1.04, 1.18

0.001

1.11

1.04, 1.18

0.002

Current CD4 ≥ 500 cells/mm3

(vs. < 500 cells/mm3)

0.60

0.37, 0.97

0.039

0.68

0.38, 1.20

0.18

Current CD4/CD8 ratio ≥ 1 (vs. < 1)

0.60

0.38, 0.95

0.029

0.68

0.39, 1.19

0.18

Baseline HIV-1 RNA

> 5 log10 copies/mL (vs. ≤5 log10 copies/mL)

0.77

0.44, 1.36

0.371

ART class

 NNRTI

Ref

Ref

 PI

2.04

1.241, 3.35

0.005

1.54

0.85,2.79

0.15

1.61

0.89, 2.90

0.11

 Other

1.66

0.87, 3.17

0.125

1.07

0.48,2.39

0.86

1.12

0.51, 2.47

0.78

Duration of ART  ≥ 10 years (vs. < 10 years)

0.75

0.37, 1.51

0.42

Frailty status

 Normal

Ref

 Pre-frailty

1.45

0.89, 2.37

0.139

1.27

0.72,2.21

0.41

1.33

0.76, 2.32

0.32

 Frailty

5.11

1.92, 13.59

0.001

3.43

1.11,10.63

0.032

3.58

1.17, 10.92

0.025

  1. *Abnormal waist circumference was defined as waist circumference > 80 cm in females and > 90 cm in males. Diabetes mellitus was defined as fasting blood glucose ≥126 mg/dL for two consecutive visits of 6 months interval or a physician diagnosis or taking anti-diabetes medications. Hypertension was defined as SBP ≥140 mmHg or DBP ≥90 mmHg for two consecutive visits of 6 months interval or taking anti-hypertensive medications
  2. Abbreviations: aOR adjusted odds ratio, BMI body mass index, LDL low-density lipoprotein, HDL high-density lipoprotein, ALT alanine aminotransferase, IL-6 interleukin-6, ART antiretroviral therapy, NNRTI non-nucleotide reverse transcriptase inhibitor, PI protease inhibitor
  3. Model 1 included current CD4 count and model 2 included current CD4/CD8 ratio in the multivariate analyses
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BMC Geriatrics

ISSN: 1471-2318

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